Deck 23: Opioid Analgesics and Antagonists

Question 1

The analgesic effect of tramadol is partly attributed to which action?

A) inhibition of prostaglandin synthesis
B) activation of descending inhibitory pathways
C) activation of α₂-adrenoceptors in the spinal cord
D) depletion of substance P from afferent neurons
E) partial agonist activity at kappa opioid receptors

Answer 1

activation of descending inhibitory pathways

Question 2

Chronic administration of meperidine should be avoided for which reason?

A) greater risk of drug dependence than with other opioids
B) auto-induction of drug metabolism enzymes
C) development of pharmacodynamic drug tolerance
D) increased suicidal ideations
E) accumulation of a toxic metabolite

Answer 2

accumulation of a toxic metabolite

Question 3

Which adverse effect may result from administration of buprenorphine to a man who is illicitly taking oxycodone?

A) hypertensive crisis
B) cardiac arrest
C) opioid withdrawal reaction
D) malignant hyperthermia
E) apnea due to depression of respiratory centers

Answer 3

opioid withdrawal reaction

Question 4

A woman experiences hallucinations and paranoid ideations after receiving an opioid analgesic in the emergency department.This adverse effect most likely results from activation of which receptors?

A) mu and delta
B) delta and kappa
C) mu and kappa
D) kappa and sigma
E) mu and sigma