Deck 24: Drugs for Neurodegenerative Diseases

Question 1

Which action is responsible for the therapeutic effects of entacapone?

A) inhibition of monoamine oxidase-type B
B) stimulation of levodopa decarboxylation
C) decreased formation of 3-O-methyldopa
D) increased uptake of dopamine into the brain
E) increased release of dopamine from neurons

Answer 1

decreased formation of 3-O-methyldopa

Question 2

Severe hypomobility ("freezing") reactions in advanced Parkinson's disease may respond rapidly after injection of which drug?

A) apomorphine
B) dopamine
C) ropinirole
D) benztropine
E) tizanidine

Answer 2

apomorphine

Question 3

Which agent is useful in persons with multiple sclerosis because it serves as a decoy for myelin-damaging T cells?

A) mitoxantrone
B) natalizumab
C) interferon beta-1b
D) glatiramer
E) prednisone

Answer 3

glatiramer

Question 4

Memantine is believed to benefit persons with Alzheimer's disease because of its ability to exert which action?

A) inhibit neurotransmitter degradation
B) increase neurotransmitter degradation
C) block neurotransmitter receptors
D) activate neurotransmitter receptors
E) block neurotransmitter reuptake