Deck 30: Drugs for Pain, Inflammation, and Arthritic Disorders

Question 1

Abatacept exerts its antirheumatic effects by binding to which molecular target?

A) interleukin-1 type I receptor
B) tumor necrosis factor-α
C) cell surface proteins of T lymphocytes
D) immunoglobulin G rheumatoid factor
E) interleukin-2 transcription factors

Answer 1

cell surface proteins of T lymphocytes

Question 2

The use of ketorolac is limited to the short-term management of postsurgical pain because long-term use is associated with a risk of which adverse effect?

A) lactic acidosis
B) heart failure
C) drug dependence
D) hepatitis
E) gastrointestinal bleeding

Answer 2

gastrointestinal bleeding

Question 3

Leflunomide prevents leukocyte proliferation by inhibiting which step in this process?

A) formation of active folate
B) pyrimidine biosynthesis
C) purine biosynthesis
D) ribonucleotide reductase
E) DNA polymerase

Answer 3

pyrimidine biosynthesis

Question 4

Administration of allopurinol produces which effect on serum and urinary levels of uric acid in a patient with gout?

A) increased serum and urinary levels
B) increased serum and decreased urinary levels
C) decreased serum levels and no change in urinary levels
D) decreased serum and urinary levels
E) decreased serum and increased urinary levels