Deck 45: Antineoplastic and Immunomodulating Drugs

Question 1

A woman with ovarian cancer receives a drug that inhibits cancer cell mitosis. What is the dose-limiting adverse effect of this drug?

A) myelosuppression
B) neuropathy
C) cardiac toxicity
D) renal insufficiency
E) hepatic dysfunction

Answer 1

myelosuppression

Question 2

Which drug reduces the supply of 5,10-methylene-tetrahydrofolate and thereby prevents formation of deoxythymidine monophosphate?

A) mercaptopurine
B) cytarabine
C) fluorouracil
D) hydroxyurea
E) methotrexate

Answer 2

methotrexate

Question 3

A woman is placed on a drug that colors the urine red. Which agent has been used to protect against the cardiac toxicity caused by this drug?

A) mesna
B) mannitol
C) leucovorin
D) dexrazoxane
E) sodium thiosulfate

Answer 3

dexrazoxane

Question 4

A man receives a monoclonal antibody for colorectal cancer. This agent binds to which target protein?

A) CD52 lymphocyte antigen
B) BCR-ABL oncoprotein
C) epidermal growth factor receptor
D) vascular endothelial growth factor
E) human epidermal growth factor-2 receptor

Question 5

Which drug increases expression of pro-apoptosis factors and reduces expression of cyclins in chronic myeloid leukemia cells?

A) gemtuzumab ozogamicin
B) imatinib
C) prednisone
D) alemtuzumab
E) fludarabine

Question 6

Increased expression of the P-glycoprotein is most likely to cause cancer cell resistance to which drug?

A) cisplatin
B) cyclophosphamide
C) cytarabine
D) vincristine
E) methotrexate