Deck 29: Drugs Used to Treat Hyperlipidemia and Related Conditions

Question 1

Higher than normal levels of cholesterol in the blood signifies a condition known as:

A) hypervolemia
B) ischemic heart disease
C) hypercholesterolemia
D) hypertension

Answer 1

hypercholesterolemia

Question 2

The most effective drugs for lowering cholesterol levels are the:

A) fibric acid derivatives
B) statins
C) bile acid sequestrants
D) nicotinic acids

Answer 2

statins

Question 3

The type of major plasma lipid that is a major component of cell membranes is the:

A) cholesterol ester
B) glycerol
C) triglyceride
D) phospholipid

Answer 3

phospholipid

Question 4

Which of the following substances bypass the liver circulation and empty into the bloodstream?

A) phospholipids
B) chylomicrons
C) triglycerides
D) cholesterol

Question 5

Type III hypercholesterolemia involves elevations of:

A) VLDL and chylomicron particles
B) lipoprotein lipase
C) LDL
D) LDL and HDL

Question 6

Type IIa hypercholesterolemia is associated with high levels of which of the following, in the blood?

A) cholesterol and HDL
B) cholesterol and LDL
C) VLDL and LDL
D) VLDL and HDL

Question 7

Type IIb hypercholesterolemia is associated with high:

A) LDL
B) HDL
C) VLDL
D) VLDL and LDL

Question 8

The trade name of colestipol is:

A) Lipitor
B) Colestid
C) Lescol
D) Zocor

Question 9

Which of the following is NOT an HMG-CoA reductase inhibitor (statin)?

A) Pravachol
B) Zocor
C) Lopid
D) Lipitor

Question 10

The trade name of rosuvastatin is:

A) Crestor
B) Zocor
C) Mevacor
D) Lescol

Question 11

The first drug that has been approved in the United States to lower proprotein convertase subtilisin Kexin 9 (PCSK-9) is:

A) gemfibrozil (Lopid )
B) simvastatin/ezetimibe (Vytorin )
C) nicotinic acid (Niacor )
D) alirocumab (Praluent )

Question 12

Moderate alcohol intake:

A) decreases HDL
B) increases HDL
C) increases VLDL
D) increases chylomicrons

Question 13

Which of the following is NOT an adverse effect of bile acid sequestrants?

A) constipation
B) flatulence
C) hypotension
D) fat-soluble vitamin impairment

Question 14

Which of the following is a severe but rare adverse effect of statin drugs?

A) encephalitis
B) rhabdomyolysis
C) aplastic anemia
D) blindness

Question 15

The trade name of gemfibrozil is:

A) Pravachol
B) Altoprev
C) Lescol
D) Lopid

Question 16

The most effective drugs for reducing LDL and cholesterol levels are:

A) HMG-CoA reductase inhibitors
B) fibric acid derivatives
C) bile acid sequestrants
D) nicotinic acids

Question 17

Which of the following are non-absorbable drugs prescribed for decreasing serum cholesterol?

A) HMG-CoA reductase inhibitors
B) fibric acid derivatives
C) bile acid sequestrants
D) nicotinic acids

Question 18

Statin drugs may increase levels of:

A) insulin
B) digoxin
C) acetaminophen
D) rifampin

Question 19

The trade name of fluvastatin is:

A) Colestid
B) Mevacor
C) Zocor
D) Lescol

Question 20

Which of the following should be avoided by patients who are taking the statin drug simvastatin?

A) coffee
B) orange juice
C) grapefruit juice
D) lemon juice

Question 21

The most common adverse effects of niacin therapy are:

A) weight loss and nausea
B) flushing and pruritus
C) severe hypertension and kidney damage
D) hypouricemia and sedation

Question 22

Fibric acid derivatives are contraindicated in patients with:

A) biliary cirrhosis
B) diabetes mellitus
C) pancreatitis
D) peptic ulcer

Question 23

Which of the following drugs is a bile acid sequestrant?

A) gemfibrozil
B) colestipol
C) atorvastatin
D) cholestyramine

Question 24

Which of the following drugs are indicated for severe familial hypercholesterolemia type IIa or type IIb?

A) nicotinic acid and vitamin E
B) fibric acid derivatives
C) statins
D) bile acid sequestrants

Question 25

The generic name of Lipitor is:

A) lovastatin
B) pravastatin
C) atorvastatin
D) fluvastatin

Question 26

A reduction in VLDL concentration may result in a decreased plasma:

A) LDL
B) HDL
C) LDL and HDL
D) chylomicron level only

Question 27

Lovastatin increases the risk of myopathy and:

A) hyperglycemia
B) hyperlipidemia
C) rhabdomyolysis
D) hypertension

Question 28

The term "epistaxis" means:

A) hematuria
B) nosebleed
C) hemosiderin
D) hemostat

Question 29

The trade name of cholestyramine resin is:

A) Colestid
B) Crestor
C) Vytorin
D) Questran