Question 1

A fungal infection is termed a:&#10;A) local infection&#10;B) phagocytosis&#10;C) mycosis&#10;D) filamentous

Accepted Answer

C) A fungal infection is termed a mycosis. The causative fungus may be either yeast or a filamentous fungus. Normal healthy individuals are resistant to most fungal infections.

Question 2

A common candidiasis infection of the mouth is known as:&#10;A) thrush&#10;B) aspergillosis&#10;C) thrombophlebitis&#10;D) gossypol

Accepted Answer

A) Also known as moniliasis, thrush is a common opportunistic candidiasis infection of the mouth caused by Candida albicans, which is a normal resident of the gastrointestinal tract and vagina.

Question 3

The term fungicidal is defined as:&#10;A) having a killing action on protozoans&#10;B) increasing fungal growth&#10;C) slowing fungal growth without destroying the fungi&#10;D) having a killing action on fungi

Accepted Answer

D) Fungicidal is defined as "having a killing action on fungi." The term "fungistatic" means "slowing fungal multiplication". Many antifungal agents affect the cell membranes of fungi and act in relation to their concentration in body tissues.

Question 4

The drug with the widest spectrum of antifungal activity is:&#10;A) griseofulvin&#10;B) amphotericin B&#10;C) flucytosine&#10;D) ketoconazole

Accepted Answer

B) Amphotericin B is the antifungal with the widest spectrum of antifungal activity of any systemic antifungal drug. Administration of this drug by the IV route is extremely useful for therapy of systemic fungal diseases such as Candida albicans.

Question 5

Most antifungal drugs act by interfering with the synthesis of:&#10;A) fluorouracil&#10;B) gossypol&#10;C) moniliasis&#10;D) ergosterol

Accepted Answer

D) Most antifungal drugs act by interfering with the synthesis of ergosterol-a chemical found in fungal cell membranes. This results in a change in the permeability of the fungal cell membrane, and either slowed growth or destruction of the fungal organism.

Question 6

The most serious adverse effect of amphotericin B is:&#10;A) fever&#10;B) renal damage&#10;C) thrombophlebitis&#10;D) loss of hearing

Accepted Answer

B) The most serious adverse effect of amphotericin B is renal damage. This drug is also able to cause blood dyscrasias and loss of hearing.

Question 7

The drug of choice to treat chromomycosis is:&#10;A) ketoconazole&#10;B) amphotericin B&#10;C) fluorouracil&#10;D) flucytosine

Accepted Answer

D) Flucytosine is the drug of choice to treat chromomycosis and of second choice to treat systemic candidiasis. It is converted in the fungus to 5-fluorouracil, which is incorporated into RNA and interferes with normal protein synthesis.

Question 8

Severe cutaneous dermatophyte infections that resist griseofulvin therapy should be treated with:&#10;A) flucytosine&#10;B) chloroquine&#10;C) ketoconazole&#10;D) amphotericin B

Accepted Answer

C) Ketoconazole is used to treat many varieties of candidiasis infections and for severe cutaneous dermatophyte infections that resist griseofulvin therapy.

Question 9

Griseofulvin is fungistatic and NOT fungicidal, and must be used systemically:&#10;A) for a long period of time&#10;B) to kill all remaining fungi&#10;C) in patients with porphyria&#10;D) to increase contraceptive efficacy

Accepted Answer

A) Because it does not kill but only arrests the reproduction of organisms, griseofulvin must be continually used for a long period of time so the entire epidermis can be replaced to remove reinfecting organisms.

Question 10

Fungal superinfections usually occur in the anal, genital, and:&#10;A) skin areas&#10;B) eye areas&#10;C) oral areas&#10;D) ear areas

Accepted Answer

C) Fungal superinfections usually occur in the anal and genital areas or in the vagina or mouth. They cause itching, vaginal discharge, and lesions on the tongue or mouth. A common type of fungal superinfection is known as candidiasis or moniliasis.

Question 11

A fungus is a one-celled plant that lacks:&#10;A) virulence&#10;B) spores&#10;C) color and chlorophyll&#10;D) pathogenicity

Accepted Answer

The answer of A fungus is a one-celled plant that...

Question 12

The trade name for nystatin is:&#10;A) Flucytosine&#10;B) Pentamidine&#10;C) Lovastatin&#10;D) Mycostatin

Accepted Answer

The answer of The trade name for nystatin is:&#10;A) Flucytosine&#10;B)...

Question 13

Candidiasis may occur because of an overgrowth of:&#10;A) yeast-like fungi&#10;B) mold-like fungi&#10;C) tissue&#10;D) a certain type of worm

Accepted Answer

The answer of Candidiasis may occur because of an overgrowth...

Question 14

Which of the following is derived from fungi?&#10;A) vaccines&#10;B) immunoglobulins&#10;C) antitoxins&#10;D) antiviral agents

Accepted Answer

The answer of Which of the following is derived from...

Question 15

Which of the following is NOT a risk factor for candidal infections?&#10;A) diabetes&#10;B) hypertension&#10;C) pregnancy&#10;D) administration of corticosteroids

Accepted Answer

The answer of Which of the following is NOT a...

Question 16

The trade name of fluconazole is:&#10;A) Diflucan&#10;B) Grifulvin V&#10;C) Amphocin&#10;D) Mycamine

Accepted Answer

The answer of The trade name of fluconazole is:&#10;A) Diflucan&#10;B)...

Question 17

The most serious toxic effect of amphotericin B is:&#10;A) liver damage&#10;B) deafness&#10;C) retinopathy&#10;D) kidney damage

Accepted Answer

The answer of The most serious toxic effect of amphotericin...

Question 18

Griseofulvin is contraindicated in patients with:&#10;A) cataracts&#10;B) porphyria&#10;C) gastritis&#10;D) pancreatitis

Accepted Answer

The answer of Griseofulvin is contraindicated in patients with:&#10;A) cataracts&#10;B)...

Question 19

Onychomycosis is also known as:&#10;A) tinea unguium&#10;B) tinea corporis&#10;C) tinea barbae&#10;D) tinea pedis

Accepted Answer

The answer of Onychomycosis is also known as:&#10;A) tinea unguium&#10;B)...

Question 20

Micafungin should NOT be given to patients who have which of the following?&#10;A) fever or chills&#10;B) liver or kidney disease&#10;C) fungal infections&#10;D) heart failure

Accepted Answer

The answer of Micafungin should NOT be given to patients...

Question 21

Terbinafine (Lamisil ) is used for the treatment of:&#10;A) histoplasmosis&#10;B) candidiasis&#10;C) blastomycosis&#10;D) onychomycosis

Accepted Answer

The answer of Terbinafine (Lamisil ) is used for the...

Question 22

The trade name of sulconazole is:&#10;A) Oxistat&#10;B) Monistat&#10;C) Exelderm&#10;D) Tinactin

Accepted Answer

The answer of The trade name of sulconazole is:&#10;A) Oxistat&#10;B)...

Question 23

The trade name of tioconazole is:&#10;A) Monistat&#10;B) Tinactin&#10;C) Oxistat&#10;D) Naftin

Accepted Answer

The answer of The trade name of tioconazole is:&#10;A) Monistat&#10;B)...

Question 24

Cryptococcal meningitis can be treated by intravenous injection of the antifungal agent known as:&#10;A) griseofulvin&#10;B) fluconazole&#10;C) voriconazole&#10;D) itraconazole

Accepted Answer

The answer of Cryptococcal meningitis can be treated by intravenous...

Question 25

Which of the following systemic antifungal agents can be administered intravenously?&#10;A) fluconazole (Diflucan )&#10;B) ketoconazole (Nizoral )&#10;C) griseofulvin (Grifulvin V )&#10;D) caspofungin (Cancidas )

Accepted Answer

The answer of Which of the following systemic antifungal agents...

Question 26

The trade name of posaconazole is:&#10;A) Noxafil&#10;B) Lamisil&#10;C) Vfend&#10;D) Nystex

Accepted Answer

The answer of The trade name of posaconazole is:&#10;A) Noxafil&#10;B)...

Question 27

Which of the antifungal agents may cause angioedema, taste sensation changes, and hepatitis?&#10;A) caspofungin&#10;B) fluconazole&#10;C) amphotericin B&#10;D) flucytosine

Accepted Answer

The answer of Which of the antifungal agents may cause...

Question 28

The trade name of voriconazole is:&#10;A) Nizoral&#10;B) Grifulvin V&#10;C) Vfend&#10;D) Lamisil

Accepted Answer

The answer of The trade name of voriconazole is:&#10;A) Nizoral&#10;B)...

Question 29

Onychomycosis is a chronic fungal disease of the:&#10;A) skin&#10;B) nails&#10;C) hair&#10;D) sweat glands

Accepted Answer

The answer of Onychomycosis is a chronic fungal disease of...

Question 30

The trade name of butenafine is:&#10;A) Naftin&#10;B) Mycostatin&#10;C) Lotrimin&#10;D) Mentax

Accepted Answer

The answer of The trade name of butenafine is:&#10;A) Naftin&#10;B)...

Deck 18: Antifungal Agents