Question 1

The study of drugs derived from herbal sources is known as:&#10;A) pharmacotherapeutics&#10;B) pharmacognosy&#10;C) pharmacokinetics&#10;D) pharmacodynamics

Accepted Answer

B) Pharmacognosy is the study of drugs derived from herbal sources, and other natural sources. By studying the compositions of natural substances and how the body reacts to them, one gains better knowledge for developing purified versions.

Question 2

Which of the following organizations is a part of the United States Department of Health and Human Services?&#10;A) DEA&#10;B) CDC&#10;C) FDA&#10;D) TJC

Accepted Answer

C) The Food and Drug Administration (FDA) is part of the United States Department of Health and Human Services. The determination of the correct use of prescription and OTC agents is controlled by the branch of the FDA known as the Center for Drug Evaluation and Research (CDER).

Question 3

Animal pharmacology and toxicology data are obtained during which of the following phases of drug approval?&#10;A) Phase I&#10;B) Phase II&#10;C) Phase III&#10;D) Phase IV

Accepted Answer

A) Phase I of drug approval is when animal pharmacology and toxicology data are obtained. This phase is known as Preclinical Investigation. It involves extensive research on human and microbial cells in a laboratory. Cultured cells and animal studies are used to determine dosages, effectiveness, and adverse effects.

Question 4

Which of the following drug approval phases consists of three trials?&#10;A) Phase I&#10;B) Phase II&#10;C) Phase III&#10;D) Phase IV

Accepted Answer

B) Phase II of drug approval consists of three trials. It is also known as Clinical Investigation, and is the longest, occurring over 2 to 10 years, 5 years being the average. Clinical Phase 1 trials occur over several months. Clinical Phase 2 trials occur over several months to 2 years. Clinical Phase 3 trials occur over 1 to 4 years.

Question 5

Which of the following is NOT an example of a drug withdrawn from the U.S. market as a result of postmarketing surveillance?&#10;A) aprotinin&#10;B) morphine sulfate&#10;C) gatifloxacin&#10;D) lumiracoxib

Accepted Answer

B) Morphine sulfate is not an example of a drug withdrawn from the U.S. market as a result of postmarketing surveillance. Examples of drugs withdrawn from the U.S. market since 2005, as a result of postmarketing surveillance, include aprotinin, propoxyphene, gatifloxacin, lumiracoxib, ozogamicin, pergolide, and sibutramine.

Question 6

Which of the following is the most famous examples of a drug that was withdrawn after postmarketing surveillance?&#10;A) celecoxib&#10;B) furosemide&#10;C) atenolol&#10;D) penbutolol

Accepted Answer

A) Celecoxib is the most famous example of a drug that was withdrawn after postmarketing surveillance. It was withdrawn along with valdecoxib and rofecoxib. All three were linked to safety concerns of stroke and heart attack. Celecoxib remains on the market, but carries a black box warning.

Question 7

Which of the following is NOT an example of a biologic drug?&#10;A) vaccine&#10;B) interferon&#10;C) antibody&#10;D) toothpaste

Accepted Answer

D) Toothpaste is not an example of a biologic drug. A drug is any agent that produces biologic responses within the body. Drugs differ from other products such as cosmetics, foods, and household chemicals, such as toothpaste, shampoo, and others.

Question 8

How many people are injured annually by medication errors in the United States?&#10;A) 99,000&#10;B) 450,000&#10;C) 840,000&#10;D) 1,300,000

Accepted Answer

D) 1,300,000 people are injured annually by medication errors in the United States, according to the Centers for Disease Control and Prevention. Medication errors cause at least one death every day.

Question 9

Which of the following four phases of drug approval includes review of the New Drug Application (NDA)?&#10;A) Phase I&#10;B) Phase II&#10;C) Phase III&#10;D) Phase IV

Accepted Answer

C) Phase III of drug approval involves review of the New Drug Application (NDA). During this phase, the trade name is finalized. Based on the preclinical testing, clinical trials and further animal testing may continue. For a new drug, it usually takes about 24 months for the full NDA review.

Question 10

Manufacturers start developing their trade names for a new drug during which of the following drug approval phases?&#10;A) Clinical phase 1 trials&#10;B) Clinical phase 2 trials&#10;C) Clinical phase 3 trials&#10;D) Phase IV

Accepted Answer

A) In Clinical Phase 1 trials, manufacturers start developing their trade name for a new drug. Dosages and adverse effects are assessed on approximately 20-100 human volunteers initially, who have the disease or condition that the drug is being tested to treat. Doses are often subtherapeutic, but ascending (increasing) doses are used.

Question 11

Complementary and alternative medicine (CAM) therapies are controlled by which of the following organizations?&#10;A) CDC&#10;B) EPA&#10;C) NCCAM&#10;D) CFSAN

Accepted Answer

The answer of Complementary and alternative medicine (CAM) therapies are...

Question 12

How long does preclinical investigation usually take?&#10;A) Between one and six months&#10;B) Between three and nine months&#10;C) Between one and three years&#10;D) Between three and nine years

Accepted Answer

The answer of How long does preclinical investigation usually take?&#10;A)...

Question 13

The percentage of drugs in clinical phase 2 trials that move on to the next phase of clinical testing is:&#10;A) 25%&#10;B) 33%&#10;C) 46%&#10;D) 78%

Accepted Answer

The answer of The percentage of drugs in clinical phase...

Question 14

Which of the following drugs carries a black box warning?&#10;A) celecoxib&#10;B) valdecoxib&#10;C) rofecoxib&#10;D) rifampin

Accepted Answer

The answer of Which of the following drugs carries a...

Question 15

Pharmacology deals with all the drugs used in society today, including prescription, legal, OTC, and ________ drugs.&#10;A) generic&#10;B) legend&#10;C) illegal&#10;D) experimental

Accepted Answer

The answer of Pharmacology deals with all the drugs used...

Question 16

Any substance intended to be used to improve a physiologic or pathologic condition is known as a:&#10;A) drug&#10;B) dose&#10;C) solution&#10;D) compound

Accepted Answer

The answer of Any substance intended to be used to...

Question 17

A &#34;medicine&#34; refers to a drug mixed with other ingredients that may improve its taste, physical form, or:&#10;A) effectiveness&#10;B) stability&#10;C) odor&#10;D) color

Accepted Answer

The answer of A &#34;medicine&#34; refers to a drug mixed...

Question 18

A sugar pill (which may be thought to be a drug by the patient) is also known as a(n):&#10;A) diet pill&#10;B) energy pill&#10;C) placebo&#10;D) antihyperglycemic agent

Accepted Answer

The answer of A sugar pill (which may be thought...

Question 19

Once a drug has been administered to a patient, it is called:&#10;A) biological&#10;B) therapeutic&#10;C) an alternative drug&#10;D) a medication

Accepted Answer

The answer of Once a drug has been administered to...

Question 20

Herbal products and dietary supplements are controlled by:&#10;A) The Center for Biologics Evaluation and Research&#10;B) The Center for Food Safety and Applied Nutrition&#10;C) The Center for Drug Evaluation and Research&#10;D) The Center for Disease Control and Prevention

Accepted Answer

The answer of Herbal products and dietary supplements are controlled...

Deck 1: Introduction to Pharmacology