Deck 21: Antineoplastic Agents

Question 1

Antimetabolites prevent cancer cell growth by which of the following mechanisms of action?

A) inhibition of cancer cell membranes
B) inhibition of DNA and RNA synthesis
C) inhibition of DNA synthesis only
D) inhibition of RNA synthesis only

Answer 1

inhibition of DNA synthesis only

Question 2

Estrogen is given to a patient with which of the following cancers?

A) breast
B) lung
C) kidney
D) testicular and prostate

Answer 2

testicular and prostate

Question 3

Which of the following antibiotics is used only to treat cancer?

A) mitomycin
B) flucytosine
C) griseofulvin
D) isoniazid

Answer 3

mitomycin

Question 4

Which of the following is the mechanism of action of hormonal agents in treating cancer?

A) they inhibit DNA and RNA synthesis
B) they inhibit DNA synthesis only
C) they inhibit RNA synthesis only
D) none of the above

Question 5

Which of the following antineoplastic agents may cause pneumonitis and pulmonary fibrosis?

A) plicamycin
B) milomycin
C) bleomycin
D) busulfan

Question 6

Which of the following was the first group of antineoplastic agents?

A) mitotic inhibitors
B) hormonal agents
C) antitumor antibiotics
D) alkylating agents

Question 7

Nitrosoureas are used in treating brain tumors and testicular or ovarian cancers. These newer drugs are categorized as which of the following antineoplastic agents?

A) hormonal agents
B) alkylating agents
C) antitumor antibiotics
D) mitotic inhibitors

Question 8

Which of the following classes of antineoplastic agents are referred to as plant alkaloids?

A) hormonal agents
B) alkylating agents
C) mitotic inhibitors
D) antitumor antibiotics

Question 9

Vincristine is used in the treatment of which of the following?

A) leukemia
B) lung cancer
C) prostate cancer
D) brain cancer

Question 10

Drugs that block cell growth by stopping cell division are referred to as:

A) monoamine oxidase inhibitors
B) mitotic inhibitors
C) decarboxylase inhibitors
D) antimetabolites

Question 11

Mercaptopurine (6-MP ) is used primarily for which of the following conditions?

A) brain and lung cancer
B) breast cancer in postmenopausal women
C) lymphocytic and myelogenous leukemia
D) all of the above

Question 12

Exposure to human papilloma viruses may cause cancer of the:

A) liver
B) intestines
C) lungs
D) cervix of the uterus

Question 13

Which of the following antimetabolites is a folic acid antagonist?

A) methotrexate
B) mercaptopurine
C) fluorouracil
D) floxuridine

Question 14

Diethylstilbestrol is used for which of the following cancers?

A) skin
B) prostate
C) leukemia
D) brain

Question 15

Which of the following is NOT an antitumor antibiotic?

A) valrubicin
B) plicamycin
C) mitoxantrone
D) mercaptopurine

Question 16

All of the following are classes of antimetabolites, except:

A) folic acid antagonists
B) purine analogs
C) nitrosoureas
D) pyrimidine analogs

Question 17

Major adverse effects of hormonal agents in female patients include:

A) feminization
B) masculization
C) anorexia
D) bone marrow suppression

Question 18

The most serious adverse effects of antitumor antibiotics include:

A) low blood cell counts
B) congestive heart failure
C) kidney and liver failure
D) A and B

Question 19

Which of the following is the trade name for fluorouracil?

A) 6-MP
B) FUDR
C) 5-FU
D) Gemzar

Question 20

All of the following drugs are nitrogen mustards, except:

A) cyclophosphamide
B) chlorambucil
C) streptozocin
D) melphalan

Question 21

Antineoplastic agents are toxic to the body as a whole because they also destroy normal cells and decrease ____________________.

Question 22

Antimetabolites are only effective against cells that are actively participating in cell ____________________.

Question 23

The abbreviation for mercaptopurine is ____________________, while the abbreviation for fluorouracil is ____________________.

Question 24

The precise action of hormones on malignant neoplasms is ____________________.

Question 25

During World War I, chemical warfare was introduced using ____________________.

Question 26

The proliferation of neoplastic cells leads to the formation of masses called __________.

Question 27

Tumors are classified clinically as either benign or __________.

Question 28

A spread of cancer cells from a primary location to other sites in the body is called __________.

Question 29

The cause of most human cancers is __________.

Question 30

Antineoplastic agents interfere with cell __________.

Question 31

Each antineoplastic agent is effective at a specific __________ in cell replication.

Question 32

Antineoplastic medications are __________ to the body as a whole because they also destroy normal cells and decrease immunity.

Question 33

Antimetabolites prevent cancer cell growth by affecting their __________ production.

Question 34

Hormonal agents are a class of __________ compounds that have various effects on cells.

Question 35

Steroids are especially useful in treating lymphomas, __________, and Hodgkin's disease.

Question 36

Estrogen therapy may cause blood __________.

Question 37

Plicamycin is used only for the treatment of __________ cancer.

Question 38

The only indication for idarubin is acute __________.

Question 39

Doxorubicin is the single most active agent against __________ cancer.

Question 40

Alkylating agents are used to treat metastatic ovarian, testicular, and __________ cancers.

Question 41

Match the each drug name to its correct classification..

-hormonal therapy

A) Prednisone
B) Plicamycin
C) Melphalan
D) Mercaptopurine
E) Vinblastine

Question 42

Match the each drug name to its correct classification..

-mitotic inhibitor

A) Prednisone
B) Plicamycin
C) Melphalan
D) Mercaptopurine
E) Vinblastine

Question 43

Match the each drug name to its correct classification..

-antimetabolite

A) Prednisone
B) Plicamycin
C) Melphalan
D) Mercaptopurine
E) Vinblastine

Question 44

Match the each drug name to its correct classification..

-alkylating agent

A) Prednisone
B) Plicamycin
C) Melphalan
D) Mercaptopurine
E) Vinblastine

Question 45

Match the each drug name to its correct classification..

-antitumor antibiotic

A) Prednisone
B) Plicamycin
C) Melphalan
D) Mercaptopurine
E) Vinblastine

Question 46

Match the generic name with the trade name.

-busulfan

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran

Question 47

Match the generic name with the trade name.

-carmustine

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran

Question 48

Match the generic name with the trade name.

-carboplatin

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran

Question 49

Match the generic name with the trade name.

-melphalan

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran

Question 50

Match the generic name with the trade name.

-estramustine

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran

Question 51

Match the generic name with the trade name.

-mitomycin

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran

Question 52

Match the generic name with the trade name.

-chlorambucil

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran

Question 53

Match the generic name with the trade name.

-cyclophosphamide

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran

Question 54

Match the generic name with the trade name.

-plicamycin

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran

Question 55

Match the generic name with the trade name.

-mechlorethamine

A) Leukeran
B) Emcyt
C) Mutamycin
D) Cytoxan
E) Mithramycin
F) Mustargen
G) Alkeran
H) Gliadel
I) Paraplatin
J) Myleran