Deck 3: Biopharmaceutics and Pharmacokinetics

Question 1

David works for a pharmaceutical company. His job includes supervising the process by which a certain group of drugs are compounded for initial delivery into the body. One might say that David is involved in:

A) biopharmaceutics.
B) drug vehicle production.
C) dosage form production.
D) b and c.
E) all of the above.

Answer 1

all of the above.

Question 2

A patient is prescribed an oral medication. It is crucial that its active ingredients not be released until the medicine reaches the small intestine. The problem is how to deliver an oral medication to this area without its activity being chemically destroyed or altered by stomach acids. In what form should this medication be delivered?

A) Compressed tablet
B) Controlled-release tablet
C) Sublingual dose form
D) Enteric-coated tablet
E) None of the above

Answer 2

Enteric-coated tablet

Question 3

A new medication is developed that consists of two immiscible liquids. One liquid appears as globules uniformly dispersed throughout the other liquid. What is most likely to be used to maintain globule stability?

A) Heat upon administration
B) Cold storage
C) An emulsifying agent
D) Mixing immediately before parenteral administration
E) b, c, and d

Answer 3

An emulsifying agent

Question 4

Jessica, a pharmaceutical manufacturer, is asked to give a lecture titled "The Transport of Drugs from Bloodstream to Site of Action." Her lecture is on:

A) absorption.
B) dissolution.
C) distribution.
D) passive diffusion.
E) reduction.

Question 5

Rate and extent of drug absorption depend on:

A) surface area at the site.
B) blood flow.
C) concentration of the drug.
D) lipophilicity.
E) all of the above.

Question 6

A patient is given a solution drug form that is observed to react in her system by moving from an area of higher concentration to an area of lower concentration. Which of the following is true?

A) This drug is traversing cellular membranes by passive diffusion.
B) Her medication is demonstrating the least common means by which drugs move through the body to the absorbing surface.
C) This route of absorption depicts the property of active transport.
D) Proteins are doing all the work of transporting this solution.
E) c and d

Question 7

A weak acid crosses barriers best when it is:

A) ionized.
B) in an acid medium.
C) in an alkaline medium.
D) a and b.
E) a and c.

Question 8

Barium is used as an oral gastrointestinal radiopaque agent because it:

A) will not interact with the gastrointestinal environment.
B) does not cross gastrointestinal membranes well.
C) will not form an insoluble complex or precipitate in the gastrointestinal medium.
D) a and b.
E) all of the above.

Question 9

When bilirubin is transformed from a lipid-soluble substance to a water-soluble substance that can be excreted in the bile, the process is referred to as:

A) conjugation.
B) oxidation.
C) hydrolysis.
D) reduction.
E) degenerative enzyme function.

Question 10

Drugs that are administered orally frequently travel first to the liver before entering the general circulation. This is referred to as:

A) biotransformation.
B) oxidation.
C) first-pass metabolism.
D) prolonged drug transformation.
E) none of the above.

Question 11

Drug molecules are eliminated from the body through:

A) the kidneys.
B) saliva.
C) the respiratory system.
D) a and c.
E) all of the above.