Deck 5: Viruses

Question 1

Clinical viral disease

A) Is most frequently due to toxin production
B) Usually follows virus infection
C) Can result without infection of host cells
D) Is associated with target organs in most disseminated viral infections

Answer 1

Is associated with target organs in most disseminated viral infections

Question 2

The eclipse period of a one-step viral multiplication curve is defined as the period of time between the

A) Uncoating and assembly of the virus
B) Start of the infection and the first appearance of extracellular virus
C) Start of the infection and the first appearance of intracellular virus
D) Start of the infection and uncoating of the virus

Answer 2

Start of the infection and the first appearance of intracellular virus

Question 3

HTLVs

A) Are associated with leukemias
B) Are defective RNA tumor viruses
C) Carry tyrosine protein kinase oncogenes
D) Synthesize early proteins that interact with p53 Rb

Answer 3

Are associated with leukemias

Question 4

Amantadine inhibits

A) Influenza A and B virus hemagglutinin binding activity
B) Influenza A virus M2 protein activity
C) Influenza A and B virus neuraminidase activity
D) Influenza B virus RNA-dependent RNA polymerase activity

Question 5

Passive immunization is available for protection from

A) Influenza A virus
B) Hepatitis A virus
C) Parainfluenza type 2 virus
D) Rubella virus

Question 6

Linear, single-stranded DNA is the genetic material of

A) Caliciviruses
B) Flaviviruses
C) Papillomaviruses
D) Parvoviruses

Question 7

Host-cell tRNAs are involved in the genome replication of

A) Influenza A virus
B) Retroviruses
C) Respiratory syncytial virus
D) Rhinovirus

Question 8

An RNA virus that has a nuclear phase to its replication process is

A) Coronavirus
B) Rhabdovirus
C) Retrovirus
D) Togavirus

Question 9

Negri bodies are associated with

A) Cytomegalovirus infections
B) Herpes simplex virus infections
C) Rabies virus infections
D) Rubella virus infections

Question 10

Persistent virus infections

A) Are usually confined to the initial site of infection
B) Are preceded by acute clinical disease
C) Elicit a poor antibody response
D) May involve infected carrier individuals

Question 11

A killed virus vaccine is

A) Jeryl Lynn mumps vaccine
B) Enders measles vaccine
C) Salk poliovirus vaccine
D) Oka varicella-zoster vaccine

Question 12

The first viral-induced defense mechanism in a nonimmune individual is the

A) Generation of cytotoxic T lymphocytes
B) Production of interferon
C) Synthesis of lymphokines
D) Synthesis of neutralizing antibodies

Question 13

Localized viral disease

A) Is a major feature of congenital viral infections
B) Is associated with a pronounced viremia
C) Can be associated with carrier individuals
D) May have systemic clinical features such as fever

Question 14

Lymphotropic and macrophage trophic designation is important in the pathogenesis of

A) Cytomegalovirus
B) Herpes simplex virus
C) Human immunodeficiency virus
D) JC virus

Question 15

Viral oncogenes are present in

A) JC virus
B) Human T-cell lymphotropic virus type 1
C) Rous sarcoma virus
D) Simian virus 40

Question 16

Dane particles are associated with

A) Hepatitis A virus
B) Hepatitis B virus
C) Hepatitis C virus
D) Hepatitis E virus

Question 17

The exchange of homologous segments of RNA between two different influenza type A viruses is called

A) Complementation
B) Genetic reassortment
C) Phenotypic masking
D) Phenotypic mixing

Question 18

The Monospot test is based on

A) Destruction of Downey cells
B) Heterophile antibodies
C) Syncytia inhibition
D) Viral capsid antigen antibodies

Question 19

Disinfection of day care center play tables with 70% ethanol is least likely to affect the viability of

A) Cytomegalovirus
B) Parainfluenza virus
C) Respiratory syncytial virus
D) Rotavirus

Question 20

The nanogram level of antigen in serum is detected by

A) Dot blot tests
B) Enzyme-linked immunosorbent assay
C) Fluorescent antibody staining
D) Protein-protein hybridization tests

Question 21

A virus that infects and lyses progenitor erythroid cells causing aplastic crises in patients with hemolytic anemia is

A) California encephalitis virus
B) Epstein-Barr virus
C) Parvovirus B19
D) Yellow fever virus

Question 22

A viral protein that is thought to induce tumors by binding to a cellular tumor suppressor protein is

A) Adenovirus E1A
B) Epstein-Barr nuclear antigen proteins
C) Hepatitis B virus e protein
D) Human immunodeficiency virus gag protein

Question 23

Viruses whose genomes have a messenger (positive-sense) polarity are

A) Adenoviruses
B) Papovaviruses
C) Paramyxoviruses
D) Polioviruses

Question 24

Antiviral nucleoside analogs

A) Are effective only against replicating viruses
B) Include foscarnet
C) Inhibit replicases
D) May block viral penetration

Question 25

A commercial vaccine consisting of virion subunits prepared by recombinant technology exists for

A) Hepatitis B virus
B) Rabies virus
C) Rotavirus
D) Varicella-zoster virus