Deck 37: Immunomodulating Agents

Question 1

Drugs are used to suppress the immune system

A) to prevent rejection of transplanted organs or tissues
B) to limit immune-mediated damage to the body's tissues
C) to treat autoimmune diseases
D) all the above are true
E) none of the above are true

Answer 1

all the above are true

Question 2

Sirolimus,a relatively new immunosuppressant,is especially helpful following kidney transplants because

A) it causes sodium retention
B) it increases renin release from the kidneys
C) it does not reduce glomerular filtration and other aspects of kidney function
D) all the above are true
E) none of the above are true

Answer 2

it does not reduce glomerular filtration and other aspects of kidney function

Question 3

Cyclosporine,an immunosuppressant that is commonly used to prevent organ rejection,is often modified into microemulsion capsules so that

A) the drugs disperses more easily within the GI tract
B) absorption of the drug from the GI tract is more predictable
C) it is not as toxic to the kidneys and other tissues
D) all the above are true
E) none of the above are true

Answer 3

all the above are true

Question 4

Cyclosporine and tacrolimus suppress immune function by inhibiting the ______ protein in lymphoid tissues which results in decreased production of _____.

A) calcineurin; interleukin-2
B) interleukin-2; immunoglobulin G
C) immunoglobulin G; prostaglandins
D) prostaglandins; interleukin-2
E) interleukin-2; calcineurin

Question 5

All of the following drugs can be used to suppress the immune system EXCEPT

A) azathioprine
B) cyclophosphamide
C) cyclosporine
D) immunoglobulin G
E) methotrexate

Question 6

Glucocorticoids such as prednisone are often used to suppress immune function following organ transplant,but long-term use of these drugs can also cause

A) hypertension
B) increased chance of infection
C) adrenocortical suppression
D) breakdown of muscle, bone, skin, and various other tissues
E) all the above are true

Question 7

Drugs that block the interleukin-2 receptor (e.g.,basiliximab [Simulect],daclizumab [Zenapax])and prevent interleukin-2 from activating T lymphocytes can be especially helpful in

A) reducing the progression of HIV infection to AIDS
B) reducing the incidence of acute organ transplant rejection
C) treating antibacterial drug resistance
D) treating antiviral drug resistance
E) reversing resistance to cancer chemotherapeutic drugs