Deck 19: Transplantation Immunology

Question 1

Matching
For each of the descriptions in questions 1-5, choose the blood group antigen (A-E) that best matches it.
Formation requires fucosyltransferase activity

A)A
B)B
C)O
D)RhD
E)Lewis

Answer 1

Lewis

Question 2

For each of the descriptions in questions , choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I) that best matches it.
Inhibits a lymphocyte-specific isoform of inosine monophosphate dehydrogenase, an enzyme that is required for the synthesis of guanine nucleotides

A)Azathioprine
B)Cyclosporine
C)Mycophenolate mofetil
D)Rapamycin
E)Anti-CD40L antibody
F)Anti-IL-2R antibody
G)CTLA4-Ig
H)OKT3
I)Corticosteroids

Answer 2

Mycophenolate mofetil

Question 3

Matching
For each of the descriptions in questions 1-5, choose the blood group antigen (A-E) that best matches it.
Common glycan that is fucosylated to form the H antigen

A)A
B)B
C)O
D)RhD
E)Lewis

Answer 3

O

Question 4

For each of the descriptions in questions , choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I) that best matches it.
Can induce anergy in T cells through inhibition of costimulatory signaling

A)Azathioprine
B)Cyclosporine
C)Mycophenolate mofetil
D)Rapamycin
E)Anti-CD40L antibody
F)Anti-IL-2R antibody
G)CTLA4-Ig
H)OKT3
I)Corticosteroids

Question 5

Matching
For each of the descriptions in questions 1-5, choose the blood group antigen (A-E) that best matches it.
Nonglycosylated red cell membrane protein missing or mutated in 15% of humans

A)A
B)B
C)O
D)RhD
E)Lewis

Question 6

Matching
For each of the descriptions in questions 1-5, choose the blood group antigen (A-E) that best matches it.
Formed by a glycosyltransferase enzyme that adds a terminal N-acetylgalactosamine residue to the H antigen

A)A
B)B
C)O
D)RhD
E)Lewis

Question 7

For each of the descriptions in questions , choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I) that best matches it.
Blocks calcineurin-dependent activation of NFAT

A)Azathioprine
B)Cyclosporine
C)Mycophenolate mofetil
D)Rapamycin
E)Anti-CD40L antibody
F)Anti-IL-2R antibody
G)CTLA4-Ig
H)OKT3
I)Corticosteroids

Question 8

Matching
For each of the descriptions in questions 1-5, choose the blood group antigen (A-E) that best matches it.
Formed by a glycosyltransferase enzyme that adds a terminal galactose residue to the H antigen

A)A
B)B
C)O
D)RhD
E)Lewis

Question 9

For each of the descriptions in questions , choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I) that best matches it.
Binds FKBP and inhibits cell cycle progression in T cells

A)Azathioprine
B)Cyclosporine
C)Mycophenolate mofetil
D)Rapamycin
E)Anti-CD40L antibody
F)Anti-IL-2R antibody
G)CTLA4-Ig
H)OKT3
I)Corticosteroids

Question 10

For each of the descriptions in questions , choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I) that best matches it.
Inhibits macrophage cytokine secretion

A)Azathioprine
B)Cyclosporine
C)Mycophenolate mofetil
D)Rapamycin
E)Anti-CD40L antibody
F)Anti-IL-2R antibody
G)CTLA4-Ig
H)OKT3
I)Corticosteroids