Question 1

Match each description in questions ,with the appropriate lettered term (A-I).
A region of an antibody molecule that permits bivalent binding of antibodies to pairs of surface epitopes varying in distance from one another

A)Conformational determinant
B)Linear determinant
C)Neoantigenic determinant
D)Hinge region
E)Immunocomplex
F)Fab
G)Fc
H)Tail piece
I)Hapten

Accepted Answer

The Fc fragment, generated by proteolytic cleavage of an antibody molecule, is composed of the C-terminal end of the heavy chain and lacks the antigen-binding region
This region of an intact Ig molecule, which can interact with Ig receptors and complement, is called the Fc region.

Question 2

Match each description in questions ,with the appropriate lettered term (A-I).
A region of an antibody molecule that permits bivalent binding of antibodies to pairs of surface epitopes varying in distance from one another

A)Conformational determinant
B)Linear determinant
C)Neoantigenic determinant
D)Hinge region
E)Immunocomplex
F)Fab
G)Fc
H)Tail piece
I)Hapten

Accepted Answer

Although haptens can be recognized by antibodies, they are not, by themselves, able to stimulate an antibody response (i.e., they are not immunogens)
Antibody responses to haptens can be induced when the hapten is attached to a macromolecule, called a carrier.

Question 3

Match each description in questions ,with the appropriate lettered term (A-I).
A region of an antibody molecule that permits bivalent binding of antibodies to pairs of surface epitopes varying in distance from one another

A)Conformational determinant
B)Linear determinant
C)Neoantigenic determinant
D)Hinge region
E)Immunocomplex
F)Fab
G)Fc
H)Tail piece
I)Hapten

Accepted Answer

Conformational determinants will usually be destroyed by physicochemical disruption of macromolecules, such as by denaturation or proteolysis of proteins.

Question 4

Matching&#10;Match each of the descriptions in questions with the correct lettered antibody isotype (A-E).&#10;(Answers may be used more than once.)&#10;The secreted form of this isotype forms pentamers around a J chain&#10;A)IgA&#10;B)IgD&#10;C)IgE&#10;D)IgG&#10;E)IgM

Accepted Answer

IgM is secreted as a J chain-linked pentamer.

Question 5

Matching&#10;Match each of the descriptions in questions with the correct lettered antibody isotype (A-E).&#10;(Answers may be used more than once.)&#10;The most abundant Ig isotype in the blood&#10;A)IgA&#10;B)IgD&#10;C)IgE&#10;D)IgG&#10;E)IgM

Accepted Answer

The blood IgG concentration is about 3.5 mg/mL and includes four subtypes (IgG1 to IgG4).

Question 6

Match each description in questions ,with the appropriate lettered term (A-I).
A region of an antibody molecule that permits bivalent binding of antibodies to pairs of surface epitopes varying in distance from one another

A)Conformational determinant
B)Linear determinant
C)Neoantigenic determinant
D)Hinge region
E)Immunocomplex
F)Fab
G)Fc
H)Tail piece
I)Hapten

Accepted Answer

Fab fragments, derived from enzymatic cleavage of Ig molecules, are composed of one intact light chain covalently linked to the N-terminal region of one heavy chain and include a single intact antigen-binding site.

Question 7

Match each description in questions ,with the appropriate lettered term (A-I).
A region of an antibody molecule that permits bivalent binding of antibodies to pairs of surface epitopes varying in distance from one another

A)Conformational determinant
B)Linear determinant
C)Neoantigenic determinant
D)Hinge region
E)Immunocomplex
F)Fab
G)Fc
H)Tail piece
I)Hapten

Accepted Answer

The hinge region, located between the two N-terminal Ig domains of the heavy chains of most isotypes, is flexible, permitting variations in the distance between the two antigen-binding sites.

Question 8

Matching&#10;Match each of the descriptions in questions with the correct lettered antibody isotype (A-E).&#10;(Answers may be used more than once.)&#10;The isotype most closely associated with immediate hypersensitivity (allergic) disease&#10;A)IgA&#10;B)IgD&#10;C)IgE&#10;D)IgG&#10;E)IgM

Accepted Answer

Most IgE that is secreted is bound to mast cells, and it plays a role in the activation of mast cells during allergic reactions.

Question 9

Matching&#10;Match each of the descriptions in questions with the correct lettered antibody isotype (A-E).&#10;(Answers may be used more than once.)&#10;The isotype only found in membrane-bound form on naive B cells&#10;A)IgA&#10;B)IgD&#10;C)IgE&#10;D)IgG&#10;E)IgM

Accepted Answer

IgD is not secreted and is found only on the surface of naive B cells
Its function is not well understood.

Question 10

Matching&#10;Match each of the descriptions in questions with the correct lettered antibody isotype (A-E).&#10;(Answers may be used more than once.)&#10;The isotype found predominantly in mucosal secretions&#160;&#10;A)IgA&#10;B)IgD&#10;C)IgE&#10;D)IgG&#10;E)IgM

Accepted Answer

IgA accounts for almost two thirds of the 3 g of antibody produced each day by an adult, most of which is produced in the gastrointestinal mucosa.

Deck 2: Antibodies and Antigens