Deck 6: Effector Mechanisms of Cell-Mediated Immunity

Question 1

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
A T cell adhesion molecule that binds to fibronectin in extracellular matrices

A)P-selectin
B)L-selectin
C)CCR8
D)Tumor necrosis factor (TNF)
E)VCAM-1
F)LFA-1
G)CCR5
H)CCR4
I)a4b7
J)Cutaneous lymphocyte antigen (CLA)
K)Mip1-a
L)VLA-4

Answer 1

VLA-4

Question 2

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
A membrane molecule expressed on T cells that promotes migration of TH2 cells into certain inflammatory sites

A)P-selectin
B)L-selectin
C)CCR8
D)Tumor necrosis factor (TNF)
E)VCAM-1
F)LFA-1
G)CCR5
H)CCR4
I)a4b7
J)Cutaneous lymphocyte antigen (CLA)
K)Mip1-a
L)VLA-4

Answer 2

CCR4

Question 3

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list.
This intracellular signaling molecule and transcription factor is activated by IL-12.

A)Interferon-γ
B)Interleukin (IL)-10
C)IL-12
D)CD40L
E)CD40
F)STAT6
G)STAT4
H)IL-5

Answer 3

STAT4

Question 4

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list.
This membrane molecule is expressed on the surface of activated TH1 cells and promotes macrophage activation.

A)Interferon-γ
B)Interleukin (IL)-10
C)IL-12
D)CD40L
E)CD40
F)STAT6
G)STAT4
H)IL-5

Question 5

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
Mediates naive CD4+ T cell migration into lymph nodes

A)P-selectin
B)L-selectin
C)CCR8
D)Tumor necrosis factor (TNF)
E)VCAM-1
F)LFA-1
G)CCR5
H)CCR4
I)a4b7
J)Cutaneous lymphocyte antigen (CLA)
K)Mip1-a
L)VLA-4

Question 6

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list.
This intracellular signaling molecule and transcription factor is required for differentiation of TH2 cells and for responses of other cells to TH2 cells.

A)Interferon-γ
B)Interleukin (IL)-10
C)IL-12
D)CD40L
E)CD40
F)STAT6
G)STAT4
H)IL-5

Question 7

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
Induces expression of endothelial selectins and Ig superfamily adhesion molecules, promoting effector T cell migration into inflammatory sites

A)P-selectin
B)L-selectin
C)CCR8
D)Tumor necrosis factor (TNF)
E)VCAM-1
F)LFA-1
G)CCR5
H)CCR4
I)a4b7
J)Cutaneous lymphocyte antigen (CLA)
K)Mip1-a
L)VLA-4

Question 8

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
A ligand on a subset of T cells that binds to E-selectin

A)P-selectin
B)L-selectin
C)CCR8
D)Tumor necrosis factor (TNF)
E)VCAM-1
F)LFA-1
G)CCR5
H)CCR4
I)a4b7
J)Cutaneous lymphocyte antigen (CLA)
K)Mip1-a
L)VLA-4

Question 9

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list.
This product of TH2 cells promotes immunity to helminthic infections.

A)Interferon-γ
B)Interleukin (IL)-10
C)IL-12
D)CD40L
E)CD40
F)STAT6
G)STAT4
H)IL-5

Question 10

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
Mediates homing of a subset of T cells into the intestinal mucosa

A)P-selectin
B)L-selectin
C)CCR8
D)Tumor necrosis factor (TNF)
E)VCAM-1
F)LFA-1
G)CCR5
H)CCR4
I)a4b7
J)Cutaneous lymphocyte antigen (CLA)
K)Mip1-a
L)VLA-4