Question 1

Matching&#10;Match each of the definitions in questions with the MHC nomenclature (A-F).&#10;Mouse major histocompatibility complex&#10;A)HLA-&#945;1&#10;, -B7, -Cw4, -DPw5, -DQw10, -DR8&#10;B)H-2&#10;C)HLA-DQ7&#10;D)I-Ad&#10;E)HLA-B5&#10;F)H-2KdI-AdI-EdDdLd

Accepted Answer

The mouse MHC is called the H-2 complex.

Question 2

For each region of a class I MHC molecule listed in questions , match the lettered label (A-D) from the diagram shown below.&#10;  &#10;Peptide-binding groove

Accepted Answer

C&#10;The peptide-binding groove of class I MHC molecules is formed by approximately 90 amino acids of the N-terminal a heavy chain, which includes the &#945;1 and &#945;2 domains This groove is composed of a floor of &#946;-pleated sheet and two parallel strands of a helix.

Question 3

For each region of a class I MHC molecule listed in questions , match the lettered label (A-D) from the diagram shown below.&#10;  &#10;&#946;2-Microglobulin

Accepted Answer

D&#10;&#946;2-Microglobulin is a separate polypeptide containing a single Ig domain, which is noncovalently associated with the extracellular region of the a heavy chain of class I MHC molecules.

Question 4

Matching&#10;Match each of the definitions in questions with the MHC nomenclature (A-F).&#10;Inbred mouse strain MHC haplotype&#10;A)HLA-&#945;1&#10;, -B7, -Cw4, -DPw5, -DQw10, -DR8&#10;B)H-2&#10;C)HLA-DQ7&#10;D)I-Ad&#10;E)HLA-B5&#10;F)H-2KdI-AdI-EdDdLd

Accepted Answer

A mouse MHC (H-2) haplotype from an inbred mouse strain will include one allele each of K, D, and L class I MHC genes and one allele each of I-A and I-E class II MHC genes
In an inbred strain, all the alleles have the same letter designation and the mice are homozygous for these alleles.

Question 5

Matching&#10;Match each of the definitions in questions with the MHC nomenclature (A-F).&#10;Human MHC haplotype&#10;A)HLA-&#945;1&#10;, -B7, -Cw4, -DPw5, -DQw10, -DR8&#10;B)H-2&#10;C)HLA-DQ7&#10;D)I-Ad&#10;E)HLA-B5&#10;F)H-2KdI-AdI-EdDdLd

Accepted Answer

An MHC haplotype is a complement of MHC genes on one chromosome, inherited from one parent
A human MHC haplotype (or HLA haplotype) includes single alleles of HLA-A, HLA-B, and HLA-C genes encoding class I MHC molecules, and HLA-DP, HLA-DQ, and HLA-DR genes, encoding class II MHC molecules.

Question 6

For each region of a class I MHC molecule listed in questions , match the lettered label (A-D) from the diagram shown below.&#10;  &#10;Polymorphic region

Accepted Answer

The answer of For each region of a class I...

Question 7

Matching&#10;Match each of the definitions in questions with the MHC nomenclature (A-F).&#10;Human class I MHC allele&#10;A)HLA-&#945;1&#10;, -B7, -Cw4, -DPw5, -DQw10, -DR8&#10;B)H-2&#10;C)HLA-DQ7&#10;D)I-Ad&#10;E)HLA-B5&#10;F)H-2KdI-AdI-EdDdLd

Accepted Answer

There are three human class I genes, HLA-A, HLA-B, and HLA-C, and each gene has many allelic forms, designated by numbers following A, B, or C.

Question 8

Matching&#10;Match each of the definitions in questions with the MHC nomenclature (A-F).&#10;Mouse class II MHC allele&#10;A)HLA-&#945;1&#10;, -B7, -Cw4, -DPw5, -DQw10, -DR8&#10;B)H-2&#10;C)HLA-DQ7&#10;D)I-Ad&#10;E)HLA-B5&#10;F)H-2KdI-AdI-EdDdLd

Accepted Answer

The mouse class II MHC genes include I-A and I-E, and the allelic forms of each are designated by superscripted letters.

Question 9

For each region of a class I MHC molecule listed in questions , match the lettered label (A-D) from the diagram shown below.&#10;  &#10;CD8-binding site

Accepted Answer

The answer of For each region of a class I...

Deck 12: The Major Histocompatibility Complex