Deck 17: Transfusion Support of Selected Patient Populations

Question 1

What is the goal of plasmapheresis in patients who will be receiving an ABO-incompatible kidney transplant?

A)Decrease white blood cell count
B)Decrease hemagglutinin titers
C)Increase haptoglobin
D)Increase hemoglobin

Answer 1

Decrease hemagglutinin titers

Question 2

Which of the following vitamins is stored in the liver?

A)B6
B)C
C)E
D)K

Answer 2

K

Question 3

Sickle cells that occlude blood vessels cause all of the following except

A)Iron overload
B)Organ damage
C)Stroke
D)Tissue ischemia

Answer 3

Iron overload

Question 4

A kidney from a donor typed as which ABO group is less likely to be rejected if transplanted into a group O patient?

A)A₁
B)A₂
C)AB
D)B

Question 5

Which is the most common inherited disease in people of African ethnicity?

A)Hemophilia A
B)Hemophilia B
C)Sickle cell disease
D)von WilLeᵇrand's disease

Question 6

Which of the following best describes an exchange transfusion?

A)Removal of patient's plasma and replacement with normal saline
B)Removal of patient's red blood cells and replacement with donor red blood cells
C)Transfusion of phenotype-matched donor red blood cells
D)Transfusion of irradiated donor red blood cells

Question 7

The goal of preventative therapy in patients with sickle cell anemia who have had a stroke is to maintain a ____________.

A)hemoglobin level above 10 g/dL (100 g/L)
B)hemoglobin S level below 30%
C)hemoglobin S level of approximately 40%
D)hematocrit level of 33-36% (0.33-0.36)

Question 8

Which of the following is a self-limited process that subsides with donor lymphocyte death?

A)Graft versus host disease
B)Hyperacute rejection
C)Iron overload
D)Passenger lymphocyte syndrome

Question 9

Transfusion-associated graft versus host disease (TA-GVHD)is

A)prevented through leukoreduction
B)almost universally fatal
C)caused by engraftment of donor B lymphoctyes
D)most often diagnosed in immunocompetent patients

Question 10

Red blood cell and platelet transfusions are used as supportive therapy in patients who have undergone a hematopoietic progenitor cell (HPC)transplant until when?

A)Chemotherapy is complete
B)CMV reactivation occurs
C)Engraftment occurs
D)Factor levels reach 70%

Question 11

Hemophilia B is due to deficiency in what coagulation factor?

A)VII
B)VIII
C)IX
D)X

Question 12

Apheresis therapy to remove white blood cells is used most commonly in what disease?

A)Acute leukemia
B)Chronic leukemia
C)Lymphoma
D)Multiple myeloma

Question 13

Which of the following is an oral iron chelator?

A)Deferasirox
B)Deferoxamine
C)Dexamethasone
D)Dimercaprol

Question 14

Hemophilia A is due to deficiency in what coagulation factor?

A)VII
B)VIII
C)IX
D)X

Question 15

Hemophilia A is managed by which of the following therapies?

A)Exchange transfusion
B)Factor replacement
C)Immune suppression
D)Therapeutic plasmapheresis

Question 16

All of the following are common manifestations of cytomegalovirus (CMV)disease except

A)Anemia
B)Gastroenteritis
C)Hepatitis
D)Pneumonia

Question 17

What is the recommended hematocrit in patients with end-stage renal disease?

A)22-25% (0.22-0.25)
B)28-33% (0.28-0.33)
C)33-36% (0.33-0.36)
D)36-42% (0.36-0.42)

Question 18

Approximately how many patients with hemophilia B form an inhibitor?

A)<5%
B)10%
C)30%
D)>35%

Question 19

Donor and patient red blood cells are typically matched for which antigens when a patient with sickle cell disease is going to be transfused?

A)C,c,E,e
B)C,E,K
C)E,K,S
D)M,N,S

Question 20

Which blood product is transfused to raise coagulation factor levels in patients with liver disease who are bleeding?

A)Cryoprecipitate
B)Factor VII
C)Fresh frozen plasma
D)Vitamin K