Deck 14: Chromosomes and Human Inheritance

ملء الشاشة (f)
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سؤال
Polyploidy can be described as ____.

A) ​only occurring artificially
B) ​only occurring when there is one set of chromosomes
C) ​fatal to all living things
D) ​occurring in about 20% of flowering plants
E) ​fatal in humans but common in flowering plants
استخدم زر المسافة أو
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لقلب البطاقة.
سؤال
Who is a carrier of an X-linked trait?

A) ​homozygous dominant female
B) ​heterozygous female
C) ​homozygous recessive female
D) ​homozygous male
E) ​heterozygous male
سؤال
Males tend to be affected in greater numbers by X-linked recessive genetic disorders than are females because​

A) ​females have two dominant genes for the disorder.
B) ​males have only one X chromosome.
C) ​males have a double dose of the gene.
D) ​Y chromosomes are not as strong as X chromosomes.
E) ​females have only one X chromosome.
سؤال
Which combination makes the most sense from an evolutionary perspective?

A) ​light skin and vitamin D deficiency
B) ​light skin and extensive exposure to sun
C) ​dark skin and little exposure to sun
D) ​dark skin and folate deficiency
E) ​light skin and little sun, or dark skin and lots of sun
سؤال
Figure 14.8
<strong>Figure 14.8   The accompanying figure represents which chromosomal change?</strong> A) ​inversion B) ​deletion C) ​duplication D) ​translocation E) ​aneuploidy <div style=padding-top: 35px>
The accompanying figure represents which chromosomal change?

A) ​inversion
B) ​deletion
C) ​duplication
D) ​translocation
E) ​aneuploidy
سؤال
A transfer of genes between non-homologous chromosomes is known as

A) ​crossing over.
B) ​aneuploidy.
C) ​trisomy.
D) ​translocation.
E) ​duplication.
سؤال
If a daughter expresses an X-linked recessive trait, she inherited the trait from____.

A) ​her mother
B) ​her father
C) ​both parents
D) ​neither parent
E) ​her grandmother
سؤال
A chromosome's gene sequence that was ABCDEFG before damage and ABFEDCG after is an example of

A) ​inversion.
B) ​deletion.
C) ​duplication.
D) ​translocation.
E) ​aneuploidy.
سؤال
What can be said about sex-determination in humans?

A) ​All human sperm carry a Y chromosome.
B) ​25% of human zygotes are XY.
C) ​All zygotes carry a Y chromosome.
D) ​Sex depends upon which type of sperm fertilizes the egg.
E) ​All human eggs carry a Y chromosome.
سؤال
How many genes are involved in determining skin color?​

A) ​1
B) ​2
C) ​10
D) ​20
E) ​more than 100
سؤال
The potential causes of chromosomal aberrations include​

A) ​viruses only.
B) ​radiation only.
C) ​a set of specific chemicals.
D) ​viruses and radiation only.
E) ​viruses, radiation, and various chemicals.
سؤال
A woman heterozygous for color blindness (an X-linked recessive allele) marries a man with normal color vision. What is the probability that their first child (male or female) will be color blind?​

A) ​25%
B) ​50%
C) ​75%
D) ​100%
E) ​0%
سؤال
Which statement about sex chromosomes is correct?

A) ​The Y chromosome carries a greater number of genes for nonsexual traits than does the X.
B) ​X and Y are different in size but carry nearly equal numbers of genes.
C) ​The X chromosome carries more genes for nonsexual traits than does the Y.
D) ​The X chromosome carries only gender-related genes.
E) ​The X chromosome carries the SRY gene.
سؤال
A human X-linked disorder is

A) ​found only in males.
B) ​more frequently expressed in females.
C) ​found on the Y chromosome.
D) ​transmitted from father to son.
E) ​more frequently expressed in males.
سؤال
The probability of producing a normal child by two parents who are carriers for an autosomal recessive disorder is ____.

A) ​0%
B) ​25%
C) ​50%
D) ​75%
E) ​100%
سؤال
Figure 14.3
<strong>Figure 14.3   Which of the following is the genetic condition observed in the woman on the left in the above figure?</strong> A) ​Huntington's disease B) ​achondroplasia C) ​triple recessive condition D) ​galactosemia E) ​muscular dystrophies <div style=padding-top: 35px>
Which of the following is the genetic condition observed in the woman on the left in the above figure?

A) ​Huntington's disease
B) ​achondroplasia
C) ​triple recessive condition
D) ​galactosemia
E) ​muscular dystrophies
سؤال
Figure 14.3
<strong>Figure 14.3   Achondroplasia ____.</strong> A) ​is inherited as an autosomal recessive condition B) ​affects about one in one million people C) ​affects only homozygotes D) ​is characterized by abnormally short arms and legs E) ​is inherited as an X-linked disorder <div style=padding-top: 35px>
Achondroplasia ____.

A) ​is inherited as an autosomal recessive condition
B) ​affects about one in one million people
C) ​affects only homozygotes
D) ​is characterized by abnormally short arms and legs
E) ​is inherited as an X-linked disorder
سؤال
<strong>  A chromosome's gene sequence that was ABCDEFG before modification and ABCDCDEFG afterward is an example of​</strong> A) ​inversion. B) ​deletion. C) ​duplication. D) ​translocation. E) ​aneuploidy. <div style=padding-top: 35px>
A chromosome's gene sequence that was ABCDEFG before modification and ABCDCDEFG afterward is an example of​

A) ​inversion.
B) ​deletion.
C) ​duplication.
D) ​translocation.
E) ​aneuploidy.
سؤال
<strong>  The accompanying figure represents which chromosomal change?</strong> A) ​inversion B) ​deletion C) ​duplication D) ​translocation E) ​aneuploidy <div style=padding-top: 35px>
The accompanying figure represents which chromosomal change?

A) ​inversion
B) ​deletion
C) ​duplication
D) ​translocation
E) ​aneuploidy
سؤال
<strong>  The accompanying figure represents which chromosomal change?</strong> A) ​inversion B) ​deletion C) ​duplication D) ​translocation E) ​aneuploidy <div style=padding-top: 35px>
The accompanying figure represents which chromosomal change?

A) ​inversion
B) ​deletion
C) ​duplication
D) ​translocation
E) ​aneuploidy
سؤال
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
inversion
سؤال
It is now possible to analyze the genetics of an in vitro fertilized embryo by

A) ​fetoscopy.
B) ​amniocentesis.
C) ​chorionic villi sampling.
D) ​pre-implantation diagnosis.
E) ​post-implantation diagnosis.
سؤال
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
SLC24A5
سؤال
__________ is a diagnostic tool that reveals missing or extra chromosomes and some structural changes in an individual's chromosomes.
سؤال
Males that tend to be taller than average and show mild mental impairment may have​

A) ​XXY chromosomes.
B) ​XYY chromosomes.
C) ​Turner syndrome.
D) ​Down syndrome.
E) ​Klinefelter syndrome.
سؤال
Changes in chromosome number are usually the result of​

A) ​genetic displacement.
B) ​trisomy.
C) ​crossing over.
D) ​nondisjunction.
E) ​disjunction.
سؤال
Amniocentesis involves sampling

A) ​the fetus directly.
B) ​the fetal cells floating in the amniotic fluid.
C) ​sperm.
D) blood cells.
E) ​placental cells.
سؤال
Symptoms of phenylketonuria (PKU) may be minimized or suppressed by a diet low in

A) ​serine.
B) glycine.
C) ​phenylalanine.
D) ​proline.
E) ​glutamic acid.
سؤال
What is the sex chromosome composition of a person with Klinefelter syndrome?​

A) ​XXX
B) ​XO
C) ​XXY
D) ​XYY
E) ​YY
سؤال
Down syndrome involves trisomy ____.

A) ​3
B) ​5
C) ​15
D) ​19
E) ​21
سؤال
A prenatal diagnosis procedure that has recently come into wide use and can be performed earlier than amniocentesis involves sampling the _____.

A) ​yolk sac material
B) ​allantois
C) ​chorion
D) ​yolk sac
E) ​umbilical cord
سؤال
The human has __________ sets of autosomal chromosomes.
سؤال
Which syndrome is characterized by a karyotype with 45 chromosomes?​

A) ​Turner
B) ​Down
C) ​androgen insensitivity
D) ​Klinefelter
E) ​cri-du-chat
سؤال
PKU detection includes​

A) ​prenatal karyotyping.
B) ​urine analysis at puberty.
C) ​blood tests at puberty.
D) ​saliva tests.
E) ​urine analysis and blood tests at birth.
سؤال
The failure of chromosomes to separate during mitosis or meiosis is called

A) ​genetic displacement.
B) ​trisomy.
C) ​crossing over.
D) ​nondisjunction.
E) ​disjunction.
سؤال
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
​translocation
سؤال
Amniocentesis is _____.

A) ​a surgical means of repairing deformities
B) ​a form of chemotherapy that modifies or inhibits gene expression or the function of gene products
C) ​used in prenatal diagnosis to detect chromosomal mutations and metabolic disorders in embryos
D) ​a form of gene replacement therapy
E) ​commonly performed on newborns
سؤال
What is the sex chromosome composition of a person with Turner syndrome?​

A) ​XXX
B) ​XO
C) ​XXY
D) ​XYY
E) ​YY
سؤال
Rarely, a chromosome's structure becomes altered when part of it undergoes duplication, deletion, __________, or __________.
سؤال
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
duplication
سؤال
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
Down syndrome
سؤال
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
A small region of a protein from three species is sequenced and found to be as follows:
Species X is alanine, glycine, threonine, alanine
Species Y is alanine, glycine, threonine, alanine
Species Z is alanine, valine, glycine, threonine, alanine
The difference in the amino acid sequence of species Z is most likely due to this.
سؤال
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
How many chromosomes does each somatic cell have in a human male who has two X chromosomes?
سؤال
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
A small region of a protein from three species is sequenced and found to be as follows:
Species X is alanine, glycine, glycine, threonine, alanine
Species Y is alanine, glycine, threonine, alanine
Species Z is alanine, glycine, glycine, threonine, alanine
The difference in the amino acid sequence of species Y is most likely due to this.
سؤال
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
Homologous sets of genes ABCDEF and ABCDEF are located on nonhomologous chromosomes.
سؤال
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
Homologous sets of genes ABCDEF and AEDCBF are located on homologous chromosomes.
سؤال
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
red-green color blindness
سؤال
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
galactosemia
سؤال
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
triploidy
سؤال
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
trisomy
سؤال
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
The nucleotide sequences of homologous regions of DNA of two species are AATGCCCCGTTA and AATGCCCCGCTTA. If this is not the result of a nucleotide base-pair addition, then it is most likely the result of this.
سؤال
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
hemophilia A
سؤال
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
How many chromosomes are present in each cell of the germ cell line for a tetraploid species whose normal complement of chromosomes is 48?
سؤال
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
How many chromosomes are present in the somatic cells of a child born with Down syndrome (trisomy 21)?
سؤال
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
monosomy
سؤال
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
The normal sperm cell of species X carries 11 chromosomes. Following nondisjunction in the formation of secondary spermatocytes and their subsequent fertilization of normal ova, some of the zygotes will have 21 chromosomes, and the remainder will have how many chromosomes?
سؤال
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
Homologous sets of genes ABCDEF and aBCdEF are located on nonhomologous chromosomes. Crossing over between them is suppressed because their locations are the result of this.
سؤال
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
Turner syndrome
سؤال
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
Following a gene duplication event involving only five loci, how many chromosomes will a human female have?
سؤال
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is an autosomal dominant disorder.
سؤال
Hemophilia is caused by an X-linked recessive gene. A normal woman whose father had hemophilia marries a normal man. What are the chances of hemophilia in their children?​
سؤال
An X-linked recessive gene (c) produces red-green color blindness. A normal woman whose father was color blind marries a color-blind man.
(a)What are the possible genotypes for the mother of the color-blind man?
(b)What are the possible genotypes for the father of the color-blind man?
(c)What are the chances that the first son will be color blind?
(d)What are the chances that the first daughter will be color blind?
سؤال
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is due to a sex chromosome abnormality probably caused by nondisjunction of sex chromosomes at meiosis.
سؤال
Red-green color blindness is an X-linked recessive trait. Two normal-vision parents have a color-blind son. Indicate the genotype and phenotype of each parent and the son.
سؤال
Short index fingers (shorter than the ring finger) are dominant in males and recessive in females, whereas long index fingers (as long as or longer than ring fingers) are dominant in females and recessive in males. Give the F2 genotype and phenotype resulting from the cross of a male with long index fingers with a female with short index fingers.
سؤال
Color blindness is an X-linked recessive gene. Two normal-vision parents produce a color-blind child.
(a)Is this child male or female?
(b)What are the genotypes of the parents?
(c)What are the chances that their next child will be a color-blind daughter?
سؤال
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is an autosomal recessive disorder.
سؤال
In humans, an X-linked disorder called coloboma iridia (a fissure in the iris) is a recessive trait. A normal couple has an afflicted daughter. The husband sues the wife for divorce on the grounds of infidelity. Would you find in his favor?
سؤال
Some conditions like progeria do not run in families despite being autosomal dominant. How is this possible?
سؤال
Which nondisjunction disorder must be due to an event in sperm development: XO, XXX, XXY or XYY?
سؤال
How did the cessation of crossing-over contribute to the disparity between the X and Y chromosomes?​
سؤال
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is an X-linked recessive trait.
سؤال
A genetic disorder has been studied through multiple generations using pedigree analysis. Every person expressing the trait has an affected parent, and both sexes are equally affected. This suggests what sort of trait and why?
سؤال
If a father and a son are both color blind and the mother is normal, is it likely that the son inherited color blindness from his father?
سؤال
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is also known as trisomy 21.
سؤال
Explain why Duchenne muscular dystrophy (DMD), a recessive condition, most commonly occurs in boys.
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ملء الشاشة (f)
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Deck 14: Chromosomes and Human Inheritance
1
Polyploidy can be described as ____.

A) ​only occurring artificially
B) ​only occurring when there is one set of chromosomes
C) ​fatal to all living things
D) ​occurring in about 20% of flowering plants
E) ​fatal in humans but common in flowering plants
E
2
Who is a carrier of an X-linked trait?

A) ​homozygous dominant female
B) ​heterozygous female
C) ​homozygous recessive female
D) ​homozygous male
E) ​heterozygous male
B
3
Males tend to be affected in greater numbers by X-linked recessive genetic disorders than are females because​

A) ​females have two dominant genes for the disorder.
B) ​males have only one X chromosome.
C) ​males have a double dose of the gene.
D) ​Y chromosomes are not as strong as X chromosomes.
E) ​females have only one X chromosome.
B
4
Which combination makes the most sense from an evolutionary perspective?

A) ​light skin and vitamin D deficiency
B) ​light skin and extensive exposure to sun
C) ​dark skin and little exposure to sun
D) ​dark skin and folate deficiency
E) ​light skin and little sun, or dark skin and lots of sun
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5
Figure 14.8
<strong>Figure 14.8   The accompanying figure represents which chromosomal change?</strong> A) ​inversion B) ​deletion C) ​duplication D) ​translocation E) ​aneuploidy
The accompanying figure represents which chromosomal change?

A) ​inversion
B) ​deletion
C) ​duplication
D) ​translocation
E) ​aneuploidy
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6
A transfer of genes between non-homologous chromosomes is known as

A) ​crossing over.
B) ​aneuploidy.
C) ​trisomy.
D) ​translocation.
E) ​duplication.
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7
If a daughter expresses an X-linked recessive trait, she inherited the trait from____.

A) ​her mother
B) ​her father
C) ​both parents
D) ​neither parent
E) ​her grandmother
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8
A chromosome's gene sequence that was ABCDEFG before damage and ABFEDCG after is an example of

A) ​inversion.
B) ​deletion.
C) ​duplication.
D) ​translocation.
E) ​aneuploidy.
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9
What can be said about sex-determination in humans?

A) ​All human sperm carry a Y chromosome.
B) ​25% of human zygotes are XY.
C) ​All zygotes carry a Y chromosome.
D) ​Sex depends upon which type of sperm fertilizes the egg.
E) ​All human eggs carry a Y chromosome.
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10
How many genes are involved in determining skin color?​

A) ​1
B) ​2
C) ​10
D) ​20
E) ​more than 100
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11
The potential causes of chromosomal aberrations include​

A) ​viruses only.
B) ​radiation only.
C) ​a set of specific chemicals.
D) ​viruses and radiation only.
E) ​viruses, radiation, and various chemicals.
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12
A woman heterozygous for color blindness (an X-linked recessive allele) marries a man with normal color vision. What is the probability that their first child (male or female) will be color blind?​

A) ​25%
B) ​50%
C) ​75%
D) ​100%
E) ​0%
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13
Which statement about sex chromosomes is correct?

A) ​The Y chromosome carries a greater number of genes for nonsexual traits than does the X.
B) ​X and Y are different in size but carry nearly equal numbers of genes.
C) ​The X chromosome carries more genes for nonsexual traits than does the Y.
D) ​The X chromosome carries only gender-related genes.
E) ​The X chromosome carries the SRY gene.
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14
A human X-linked disorder is

A) ​found only in males.
B) ​more frequently expressed in females.
C) ​found on the Y chromosome.
D) ​transmitted from father to son.
E) ​more frequently expressed in males.
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15
The probability of producing a normal child by two parents who are carriers for an autosomal recessive disorder is ____.

A) ​0%
B) ​25%
C) ​50%
D) ​75%
E) ​100%
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16
Figure 14.3
<strong>Figure 14.3   Which of the following is the genetic condition observed in the woman on the left in the above figure?</strong> A) ​Huntington's disease B) ​achondroplasia C) ​triple recessive condition D) ​galactosemia E) ​muscular dystrophies
Which of the following is the genetic condition observed in the woman on the left in the above figure?

A) ​Huntington's disease
B) ​achondroplasia
C) ​triple recessive condition
D) ​galactosemia
E) ​muscular dystrophies
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17
Figure 14.3
<strong>Figure 14.3   Achondroplasia ____.</strong> A) ​is inherited as an autosomal recessive condition B) ​affects about one in one million people C) ​affects only homozygotes D) ​is characterized by abnormally short arms and legs E) ​is inherited as an X-linked disorder
Achondroplasia ____.

A) ​is inherited as an autosomal recessive condition
B) ​affects about one in one million people
C) ​affects only homozygotes
D) ​is characterized by abnormally short arms and legs
E) ​is inherited as an X-linked disorder
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18
<strong>  A chromosome's gene sequence that was ABCDEFG before modification and ABCDCDEFG afterward is an example of​</strong> A) ​inversion. B) ​deletion. C) ​duplication. D) ​translocation. E) ​aneuploidy.
A chromosome's gene sequence that was ABCDEFG before modification and ABCDCDEFG afterward is an example of​

A) ​inversion.
B) ​deletion.
C) ​duplication.
D) ​translocation.
E) ​aneuploidy.
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19
<strong>  The accompanying figure represents which chromosomal change?</strong> A) ​inversion B) ​deletion C) ​duplication D) ​translocation E) ​aneuploidy
The accompanying figure represents which chromosomal change?

A) ​inversion
B) ​deletion
C) ​duplication
D) ​translocation
E) ​aneuploidy
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20
<strong>  The accompanying figure represents which chromosomal change?</strong> A) ​inversion B) ​deletion C) ​duplication D) ​translocation E) ​aneuploidy
The accompanying figure represents which chromosomal change?

A) ​inversion
B) ​deletion
C) ​duplication
D) ​translocation
E) ​aneuploidy
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21
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
inversion
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22
It is now possible to analyze the genetics of an in vitro fertilized embryo by

A) ​fetoscopy.
B) ​amniocentesis.
C) ​chorionic villi sampling.
D) ​pre-implantation diagnosis.
E) ​post-implantation diagnosis.
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23
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
SLC24A5
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24
__________ is a diagnostic tool that reveals missing or extra chromosomes and some structural changes in an individual's chromosomes.
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25
Males that tend to be taller than average and show mild mental impairment may have​

A) ​XXY chromosomes.
B) ​XYY chromosomes.
C) ​Turner syndrome.
D) ​Down syndrome.
E) ​Klinefelter syndrome.
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26
Changes in chromosome number are usually the result of​

A) ​genetic displacement.
B) ​trisomy.
C) ​crossing over.
D) ​nondisjunction.
E) ​disjunction.
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27
Amniocentesis involves sampling

A) ​the fetus directly.
B) ​the fetal cells floating in the amniotic fluid.
C) ​sperm.
D) blood cells.
E) ​placental cells.
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28
Symptoms of phenylketonuria (PKU) may be minimized or suppressed by a diet low in

A) ​serine.
B) glycine.
C) ​phenylalanine.
D) ​proline.
E) ​glutamic acid.
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29
What is the sex chromosome composition of a person with Klinefelter syndrome?​

A) ​XXX
B) ​XO
C) ​XXY
D) ​XYY
E) ​YY
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30
Down syndrome involves trisomy ____.

A) ​3
B) ​5
C) ​15
D) ​19
E) ​21
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31
A prenatal diagnosis procedure that has recently come into wide use and can be performed earlier than amniocentesis involves sampling the _____.

A) ​yolk sac material
B) ​allantois
C) ​chorion
D) ​yolk sac
E) ​umbilical cord
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32
The human has __________ sets of autosomal chromosomes.
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33
Which syndrome is characterized by a karyotype with 45 chromosomes?​

A) ​Turner
B) ​Down
C) ​androgen insensitivity
D) ​Klinefelter
E) ​cri-du-chat
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34
PKU detection includes​

A) ​prenatal karyotyping.
B) ​urine analysis at puberty.
C) ​blood tests at puberty.
D) ​saliva tests.
E) ​urine analysis and blood tests at birth.
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35
The failure of chromosomes to separate during mitosis or meiosis is called

A) ​genetic displacement.
B) ​trisomy.
C) ​crossing over.
D) ​nondisjunction.
E) ​disjunction.
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36
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
​translocation
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37
Amniocentesis is _____.

A) ​a surgical means of repairing deformities
B) ​a form of chemotherapy that modifies or inhibits gene expression or the function of gene products
C) ​used in prenatal diagnosis to detect chromosomal mutations and metabolic disorders in embryos
D) ​a form of gene replacement therapy
E) ​commonly performed on newborns
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38
What is the sex chromosome composition of a person with Turner syndrome?​

A) ​XXX
B) ​XO
C) ​XXY
D) ​XYY
E) ​YY
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39
Rarely, a chromosome's structure becomes altered when part of it undergoes duplication, deletion, __________, or __________.
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40
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
duplication
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41
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
Down syndrome
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42
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
A small region of a protein from three species is sequenced and found to be as follows:
Species X is alanine, glycine, threonine, alanine
Species Y is alanine, glycine, threonine, alanine
Species Z is alanine, valine, glycine, threonine, alanine
The difference in the amino acid sequence of species Z is most likely due to this.
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43
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
How many chromosomes does each somatic cell have in a human male who has two X chromosomes?
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44
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
A small region of a protein from three species is sequenced and found to be as follows:
Species X is alanine, glycine, glycine, threonine, alanine
Species Y is alanine, glycine, threonine, alanine
Species Z is alanine, glycine, glycine, threonine, alanine
The difference in the amino acid sequence of species Y is most likely due to this.
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45
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
Homologous sets of genes ABCDEF and ABCDEF are located on nonhomologous chromosomes.
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46
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
Homologous sets of genes ABCDEF and AEDCBF are located on homologous chromosomes.
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47
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
red-green color blindness
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48
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
galactosemia
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49
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
triploidy
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50
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
trisomy
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51
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
The nucleotide sequences of homologous regions of DNA of two species are AATGCCCCGTTA and AATGCCCCGCTTA. If this is not the result of a nucleotide base-pair addition, then it is most likely the result of this.
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52
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
hemophilia A
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53
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
How many chromosomes are present in each cell of the germ cell line for a tetraploid species whose normal complement of chromosomes is 48?
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54
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
How many chromosomes are present in the somatic cells of a child born with Down syndrome (trisomy 21)?
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55
Choose the most appropriate answer for each.​
a.​3n; generally sterile
b.​a chromosome segment is permanently transferred to a nonhomologous chromosome
c.​(2n - 1); a zygote deprived of a chromosome
d.​a repeat of a particular DNA sequence in the same chromosome or in nonhomologous ones
e.​(2n + 1); three chromosomes of the same kind are present in a set of chromosomes
f.​a piece of the chromosome is inadvertently left out during the repair process
g.​encodes a transport protein in melanosome membranes
h.​a chromosome segment that has been cut out and rejoined at the same place, but backward
monosomy
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56
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
The normal sperm cell of species X carries 11 chromosomes. Following nondisjunction in the formation of secondary spermatocytes and their subsequent fertilization of normal ova, some of the zygotes will have 21 chromosomes, and the remainder will have how many chromosomes?
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57
Select the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement.​
a.​inversion
b.​deletion
c.​gene duplication
d.​translocation
e.​addition
Homologous sets of genes ABCDEF and aBCdEF are located on nonhomologous chromosomes. Crossing over between them is suppressed because their locations are the result of this.
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58
Match the cause with the disorder.​
a.​autosomal recessive inheritance; lactose metabolism is blocked
b.​nondisjunction of the twenty-first chromosomal pair
c.​X-linked recessive inheritance
d.​nondisjunction of the sex chromosomes
Turner syndrome
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59
Answer the following questions in reference to the five items listed below.​
a.​12
b.​23
c.​24
d.​46
e.​47
Following a gene duplication event involving only five loci, how many chromosomes will a human female have?
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60
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is an autosomal dominant disorder.
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61
Hemophilia is caused by an X-linked recessive gene. A normal woman whose father had hemophilia marries a normal man. What are the chances of hemophilia in their children?​
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62
An X-linked recessive gene (c) produces red-green color blindness. A normal woman whose father was color blind marries a color-blind man.
(a)What are the possible genotypes for the mother of the color-blind man?
(b)What are the possible genotypes for the father of the color-blind man?
(c)What are the chances that the first son will be color blind?
(d)What are the chances that the first daughter will be color blind?
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63
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is due to a sex chromosome abnormality probably caused by nondisjunction of sex chromosomes at meiosis.
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64
Red-green color blindness is an X-linked recessive trait. Two normal-vision parents have a color-blind son. Indicate the genotype and phenotype of each parent and the son.
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65
Short index fingers (shorter than the ring finger) are dominant in males and recessive in females, whereas long index fingers (as long as or longer than ring fingers) are dominant in females and recessive in males. Give the F2 genotype and phenotype resulting from the cross of a male with long index fingers with a female with short index fingers.
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66
Color blindness is an X-linked recessive gene. Two normal-vision parents produce a color-blind child.
(a)Is this child male or female?
(b)What are the genotypes of the parents?
(c)What are the chances that their next child will be a color-blind daughter?
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67
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is an autosomal recessive disorder.
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68
In humans, an X-linked disorder called coloboma iridia (a fissure in the iris) is a recessive trait. A normal couple has an afflicted daughter. The husband sues the wife for divorce on the grounds of infidelity. Would you find in his favor?
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69
Some conditions like progeria do not run in families despite being autosomal dominant. How is this possible?
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70
Which nondisjunction disorder must be due to an event in sperm development: XO, XXX, XXY or XYY?
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71
How did the cessation of crossing-over contribute to the disparity between the X and Y chromosomes?​
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72
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is an X-linked recessive trait.
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73
A genetic disorder has been studied through multiple generations using pedigree analysis. Every person expressing the trait has an affected parent, and both sexes are equally affected. This suggests what sort of trait and why?
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74
If a father and a son are both color blind and the mother is normal, is it likely that the son inherited color blindness from his father?
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75
Select the disorder that best matches each the following statements.​
a.​galactosemia
b.​Turner syndrome
c.progeria
d.​hemophilia A
e.​Down syndrome
This disorder is also known as trisomy 21.
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76
Explain why Duchenne muscular dystrophy (DMD), a recessive condition, most commonly occurs in boys.
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