Deck 6: Other Blood Group Systems

Question 1

A person who inherits the Le, Se, and H genes will have red cells that phenotype:

A) Le(a+b+).
B) Le(a-b+).
C) Le(a-b-).
D) Le(a+b-).

Answer 1

B
Inheriting H, Se, and Le genes will allow the Lewis transferase to convert H to Le^b antigen and to be absorbed onto the red cells.

Question 2

Antibodies to Kidd, Kell, and Duffy blood group antigens share all the following characteristics except:

A) can cause hemolytic disease of the newborn.
B) usually detected only by the indirect antiglobulin test.
C) enhanced with enzyme treatment.
D) can cause transfusion reactions.

Answer 2

C
The Duffy system antibodies do not react with enzyme treated cells.

Question 3

Red cells that phenotype as S-s- are also:

A) M-negative.
B) N-negative.
C) Tj^a-negative.
D) U-negative.

Answer 3

D
When S and s are absent from the membrane, the high-frequency antigen U is also absent.

Question 4

Lewis system antibodies have not been implicated in hemolytic disease of the fetus and newborn because:

A) the antigens are not fully developed at birth.
B) Lewis system antibodies do not cross the placenta.
C) the antibodies are not clinically significant.
D) all of the above are correct.

Question 5

Which of the following phenotypes is heterozygous?

A) Fy(a-b+)
B) Jk(a+b-)
C) Fy(a+b+)
D) Le(a+b-)

Question 6

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
Antigen associated with human T-lymphocyte antigen antibodies

Question 7

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
Antigen of high incidence; antibody to it can cause severe transfusion reactions

Question 8

The Donath-Landsteiner antibody is:

A) an IgG auto anti-P.
B) an IgM auto anti-I.
C) anti-IH that reacts at cold temperatures.
D) IgG anti-p^k.

Question 9

Antibodies to which of the following blood group system show dosage (i.e., are stronger with homozygous expression of the antigen)?

A) Lutheran
B) P
C) Duffy
D) Kell

Question 10

K1-positive donor red cells were mistakenly transfused to a recipient with anti-K. The patient's posttransfusion blood sample has a positive direct antiglobulin test with polyspecific antihuman globulin. The direct antiglobulin test is positive because anti-K is an __________ antibody that has sensitized the __________ cells in vivo.

A) IgG, donor's
B) IgM, donor's
C) IgG, recipient's
D) IgM, recipient's

Question 11

Which of the following facts is not a characteristic of Kell system antibodies?

A) Usually clinically significant IgG antibodies
B) Best detected in indirect antiglobulin test phases
C) Lose reactivity with proteolytic enzyme reagents
D) Do not bind complement proteins

Question 12

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
Antigen has a higher frequency in females

Question 13

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
System associated with McLeod phenotype

Question 14

If all red cells tested at room temperature are positive with a patient's serum except for cord cells, the probably antibody identity is:

A) anti-Lu.
B) anti-Le^a.
C) anti-I.
D) anti-M.

Question 15

Antibodies to Lu^b antigen are not commonly detected because:

A) Lu^b antigen is of high incidence.
B) the antibodies do not cause transfusion reactions.
C) Lu^b antigen is not present on screening cells.
D) the antibodies react best at 4° C.

Question 16

Which condition is often associated with the presence of anti-I?

A) Infectious mononucleosis
B) Mycoplasma pneumoniae infection
C) Pregnancy
D) Colon cancer

Question 17

All the following statements are true regarding Lewis system antibodies except antibodies:

A) may be observed at the immediate spin, 37° C, and antihuman globulin phases.
B) can be neutralized by Lewis substance.
C) may cause hemolysis in vitro.
D) do not react following enzyme treatment of cells.

Question 18

Antigens of the P system are structurally related to which of the following blood group systems?

A) MNS
B) ABH
C) Kell
D) Duffy

Question 19

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
Antigens Yt^a and Yt^b are in this system

Question 20

The following statements regarding anti-P₁ are true except:

A) anti-P₁ will not react with enzyme-treated P₁ positive red cells.
B) P₂ individuals can make anti-P_1.
C) anti-P₁ is clinically not significant.
D) anti-P₁ reacts best at room temperature.

Question 21

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
System associated with glycophorin A and B

Question 22

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
System associated with resistance to malaria

Question 23

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
Antibody to this antigen demonstrates weak mixed field reactions

Question 24

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
System associated with chronic granulomatous disease

Question 25

Match each characteristic with the appropriate blood group system. A selection may be used more than once.
a.Cartwright
b.MNSs
c.Kidd
d.Bg
e.Xg^a
f.Sd^a antigen
g.Chido
h.Knops
i.Duffy
j.Vel
Antibodies in this system often fall below detectable levels and are associated with delayed transfusion reactions