Deck 23: Therapeutic Agents for the Immune System

Question 1

Chronic inflammation can:

A)Occur locally or systemically.
B)Lead to the development of scar tissue.
C)Alter an organ's ability to function optimally.
D)All of the above are characteristics of chronic inflammation.

Answer 1

D
Chronic inflammation can occur locally, such as at a cut on the surface of the skin, or systemically, throughout the body. It can cause damage to the affected sites or to the internal organs. As the body heals, it may leave behind scar tissue, which can alter the affected area's physiologic structure.

Question 2

Hematopoiesis is:

A)Blood cell production
B)Blood cell destruction
C)Ratio of white-to-red blood cells
D)Disease of the blood cells

Answer 2

A
Hematopoiesis, or blood cell production, takes place in the bone marrow.

Question 3

Which of the following is(are) autoimmune disorders?

A)Systemic lupus erythematosus (SLE)
B)Psoriasis
C)Rheumatoid arthritis (RA)
D)All of the above

Answer 3

D
Autoimmune disorders include Crohn disease, myasthenia gravis, psoriasis, SLE, RA, Graves disease, and Hashimoto thyroiditis (also known as Hashimoto disease).

Question 4

Methotrexate (Rheumatrex) for RA can be orally administered:

A)Once weekly as a single dose
B)Every 12 hours for three doses once weekly
C)Daily
D)A or B

Question 5

Which of the following medications for rheumatoid arthritis can be orally administered?

A)Methotrexate
B)Etanercept
C)Adalimumab
D)Abatecept

Question 6

Graves disease is an autoimmune disease that:

A)Leads to hypothyroidism
B)Leads to hyperthyroidism
C)Can be treated with thyroid supplements
D)A and C

Question 7

Which organ produces lymphocytes and gradually shrinks as a person ages?

A)Thymus
B)Tonsils
C)Spleen
D)Pancreas

Question 8

Which of the following statements is not true regarding adaptive immunity?

A)Adaptive immunity involves cells that rapidly respond to infection.
B)Lymphocytes are the key cells involved with adaptive immunity.
C)Adaptive immunity involves the production of antibodies specific to an individual antigen.
D)T cells and B cells are involved with adaptive immunity.

Question 9

Propylthiouracil and methimazole are used to treat:

A)RA
B)Hyperthyroidism
C)Hypothyroidism
D)SLE

Question 10

DMARDs are:

A)Disease-modifying antiinflammatory drugs
B)Disease-modifying action drugs
C)Disease-modifying antirheumatic drugs
D)Disease-modifying aggravating drugs

Question 11

RA:

A)Is a disease that predominately affects older adults.
B)Is curable with prednisone and nonsteroidal antiinflammatory drugs (NSAIDs).
C)Leads to irreversible joint deformity.
D)Affects men more than women.

Question 12

Belimumab (Benlysta) for SLE is available:

A)Orally
B)Topically
C)Intravenously (IV)
D)All of the above

Question 13

Propylthiouracil is used:

A)To decrease thyroid production in Graves disease
B)As a thyroid supplement
C)To treat hypothyroidism
D)A and C

Question 14

Which of the following statements is(are) true regarding cytokines?

A)Cytokines are secreted by a variety of cells, including immune cells.
B)They signal inflammation and the activation of immune responses.
C)Cytokines include tumor necrosis factor (TNF) and interleukin-1 (IL-1).
D)All of the above are true statements.

Question 15

Which of the following statements does not describe the spleen?

A)The spleen contains macrophages.
B)It is made up of red pulp and white pulp.
C)The spleen is the largest lymphatic organ.
D)It filters blood cells at the beginning of their life cycle.

Question 16

Rapamune and Nulojix are indicated for:

A)Prevention of kidney transplant rejection
B)SLE
C)RA
D)Prevention of shingles

Question 17

A major side effect with immunosuppressive therapy is:

A)Nausea and vomiting
B)Increased risk of infection
C)Cough
D)B and C

Question 18

Which of the following is not a major organ in the lymphatic system?

A)Thymus
B)Kidneys
C)Bone marrow
D)Spleen

Question 19

The most common cause of hypothyroidism in the United States is which one of the following autoimmune diseases?

A)Hashimoto thyroiditis
B)SLE
C)RA
D)Type I diabetes

Question 20

Side effects for azathioprine (Imuran) include:

A)Bone marrow suppression
B)Nausea and vomiting
C)Increased risk of infection
D)All of the above

Question 21

Vaccines are available for:

A)Bacterial and viral diseases
B)Fungal infections
C)Parasitic infections
D)All of the above

Question 22

Tetanus toxoid:

A)Is an active bacterial toxin.
B)Is not necessary for those older than 18 years of age.
C)Requires a booster every 10 years.
D)A and B

Question 23

Which of the following statements is(are) true about the vaccination Gardasil?

A)Gardasil is administered to prevent HPV.
B)It is licensed for use in male and female children and young adults (9 to 26 years of age).
C)Gardasil is given IV.
D)A and B

Question 24

Why is it important for a pharmacy technician to have a record of up-to-date immunizations?

A)Many hospitals require proof of childhood immunizations before hiring technicians.
B)Many hospitals require proof of childhood immunizations before providing externships.
C)Records can provide information to avoid numerous blood tests to prove previous immunizations.
D)All of the above statements apply.

Question 25

Many diseases that were previously responsible for illnesses and deaths are now rare because:

A)Immunizations have widespread use.
B)Humans have naturally developed antibodies.
C)Better sanitation practices exist worldwide today.
D)More people visit physicians.

Question 26

What agents contain antibodies that can neutralize dangerous toxins?

A)Antitoxins
B)Antivenins
C)Antibiotics
D)A and B

Question 27

Which of the following statements is true of live vaccines?

A)Live vaccines lead to the development of active acquired immunity.
B)Periodic booster shots are required.
C)Live vaccines carry no risk of infection.
D)Live vaccines are always effective.

Question 28

If a person steps on a rusty nail and has not had a booster in 10 years, then he or she should get a:

A)Tetanus toxoid
B)Diphtheria-pertussis-tetanus (DPT) vaccination
C)Tetanus antitoxin
D)Tetanus booster

Question 29

Most vaccines require:

A)Refrigeration between 2° and 8° C
B)Freezing
C)Careful temperature monitoring during shipping and storage
D)A and C

Question 30

Attenuated, in reference to vaccines, means:

A)Dead
B)Weakened
C)Potent
D)Viral

Question 31

The brand name for the biologic response modifier (BRM) etanercept is:

A)Humira
B)Enbrel
C)Remicade
D)Cimzia

Question 32

Which of the following would not be considered an antigen?

A)Virus
B)Foreign substance that causes a disease
C)Foreign substance that causes no reaction
D)Foreign substance that causes an allergy

Question 33

Zostavax is indicated for the prevention of:

A)Chickenpox
B)Shingles
C)Haemophilus influenzae
D)Tetanus

Question 34

What happens when a vaccine requiring storage between 2° and 8° C is frozen?

A)The vaccine must be slowly thawed to the proper temperature before administering.
B)Vaccines may be kept frozen until 24 hours before administering.
C)The vaccine may be ineffective and should not be administered.
D)Freezing the vaccine extends the expiration date by 6 months.

Question 35

Which of the following statements is(are) true concerning an inactivated viral vaccine?

A)The immune system recognizes the viral capsid (outer covering).
B)Boosters must be administered.
C)The virus is attenuated.
D)A and B