Deck 6: Treatment of Depression

Question 1

Drugs that antagonize 5-HT₂A and 5-HT₂C reuptake receptors in the treatment of depression and negative-symptom schizophrenia include which of the following?

A)Mirtazapine
B)Trazodone
C)Lamotrigine
D)Fluoxetine

Answer 1

Fluoxetine

Question 2

If depletion of monoamine neurotransmitters causes depression,what is the effect of excessive levels of these neurotransmitters?

A)Schizophrenia
B)Major depression
C)Mania
D)Serotonin syndrome

Answer 2

Mania

Question 3

When lithium has not demonstrated its desired results,which of the following can be used as an adjunct therapy drug?

A)Aripiprazole
B)Lamotrigine
C)Tranylcypromine
D)Sertraline

Answer 3

Lamotrigine

Question 4

All of the following are types of depressive disorders except _____.

A)schizophrenia
B)bipolar
C)dysthymia
D)clinical depression

Question 5

Which of the following is an example of an SNRI?

A)Amitriptyline
B)Divalproex
C)Trazodone
D)Duloxetine

Question 6

Why would a long half-life be beneficial yet unfavorable when taking a TCA?

A)It would allow for increased chance of elimination,reducing its effects.
B)The drug would allow for decreased dosing,but side effects would last longer.
C)A longer half-life increases the chance of the drug being metabolized,decreasing possible side effects.
D)The drug would allow for decreased dosing but would also decrease its therapeutic effects.

Question 7

If TCAs block cholinergic receptors,which of the following would you suspect to be a side effect?

A)Increased urination
B)Excess salivation
C)Sedation
D)Blurred vision

Question 8

Most of the drugs currently indicated for the treatment of bipolar disorder are listed in which U.S.Food and Drug Administration (FDA)pregnancy category?

A)Category A
B)Category B
C)Category C
D)Category D

Question 9

Which of the following explains how tyramine-containing foods can induce hypertensive crisis when taking an monoamine oxidase inhibitor (MAOI)?

A)Because MAOIs induce the production of tyramine,adding more to the body would cause a buildup in blood circulation,resulting in hypertensive crisis.
B)Adding additional tyramine in the diet could induce NE to be released from storage,potentially causing dangerously high levels of NE as MAO is not available to break tyramine down.
C)Additional tyramine would be available in the synaptic cleft,allowing it to bind the receptors,causing hypertensive crisis.
D)Having too much tyramine in the body would force the body to reuptake it,resulting in hypertensive crisis.

Question 10

Which of the following does not precipitate depressive disorders?

A)Hormonal changes
B)Substance abuse
C)Illnesses
D)Gluttony

Question 11

Venlafaxine belongs to which class of drugs?

A)MAOI
B)SSRI
C)Serotonin-noradrenaline reuptake inhibitor (SNRI)
D)TCA

Question 12

Which of the following is an example of an MAOI?

A)Imipramine
B)Tranylcypromine
C)Mirtazapine
D)Citalopram

Question 13

Which of the following describes why the inhibition of the reuptake of neurotransmitters to treat depression is therapeutic?

A)By blocking the reuptake,it allows the body to take a break from releasing metabolizing amino acids preventing the breakdown of the neurotransmitters.
B)Inhibiting the reuptake prevents the neurotransmitters from binding,allowing them to stay in the synaptic cleft longer.
C)When reuptake is blocked,the neurotransmitters have a better chance of binding to postsynaptic receptor sites.
D)Blocking the reuptake allows for binding inhibition,leaving more "happy" neurotransmitters floating around.

Question 14

Why do plasma levels and renal function need to be monitored when taking lithium?

A)To make sure sodium levels are increased to allow for resorption of lithium
B)To ensure lithium is not being reabsorbed through the kidneys,causing lithium toxicity
C)To make sure sodium is allowing for resorption of lithium to increase lithium levels in the body
D)To ensure lithium is being reabsorbed through the liver and remaining in the body to produce its effects

Question 15

When heart disease is present,which of the following drugs should be prescribed to allow for less cardiotoxic effects?

A)Paroxetine
B)Amitriptyline
C)Nortriptyline
D)Imipramine

Question 16

The monoamine neurotransmitters that are depleted in clinical depressions are NE,_____,and dopamine (DA).

A)GABA
B)5-HT
C)EPI
D)glutamate

Question 17

Which of the following is an example of an SSRI?

A)Nortriptyline
B)Phenelzine
C)Bupropion
D)Sertraline

Question 18

Which of the following foods/beverages should not be eaten when taking an MAOI?

A)Chocolate
B)Cottage cheese
C)Grapefruit juice
D)Decaffeinated drinks

Question 19

Which statement is not true about lithium?

A)It has a narrow therapeutic index.
B)It absorbed in the gastrointestinal (GI)tract.
C)It has a slow onset of action.
D)It has a t 1/2 of 24 hours.

Question 20

One of the more common side effects of SSRIs is _____.

A)sedation
B)dry mouth
C)insomnia
D)weight gain

Question 21

Minor depression is not called clinical depression.

Question 22

Heredity plays no part in bipolar disorder.

Question 23

Dysthymia symptoms are more severe than those of major depression.

Question 24

MATCHING
Match each of the following generic names with its trade name.
a.Tranylcypromine
b.Imipramine
c.Citalopram
d.Doxepin
e.Escitalopram
Lexapro

Question 25

MATCHING
Match each of the following generic names with its trade name.
a.Tranylcypromine
b.Imipramine
c.Citalopram
d.Doxepin
e.Escitalopram
Parnate

Question 26

MATCHING
Match each of the following generic names with its trade name.
a.Tranylcypromine
b.Imipramine
c.Citalopram
d.Doxepin
e.Escitalopram
Tofranil

Question 27

MATCHING
Match each of the following generic names with its trade name.
a.Tranylcypromine
b.Imipramine
c.Citalopram
d.Doxepin
e.Escitalopram
Sinequan

Question 28

Serotonin (5-hydroxytryptamine [5-HT])is an inhibitory transmitter.

Question 29

MATCHING
Match each of the following generic names with its trade name.
a.Tranylcypromine
b.Imipramine
c.Citalopram
d.Doxepin
e.Escitalopram
Celexa

Question 30

Which of the following is an example of a TCA?

A)Protriptyline
B)Carbamazepine
C)Mirtazapine
D)Fluvoxamine

Question 31

Tricyclic antidepressants (TCAs)are used only to treat depression.