Deck 13: Neuromuscular Blockade

Question 1

What drugs should be administered with neuromuscular blocking drugs during surgery?

A)Antianxiety
B)Analgesics
C)Central nervous system depressants
D)Beta blockers

Answer 1

Analgesics

Question 2

Most neuromuscular blocking drugs are poorly absorbed from the gastrointestinal tract;therefore,they are administered _____.

A)topically
B)parenterally
C)transdermally
D)orally

Answer 2

parenterally

Question 3

An example of a drug or substance that decreases ACh release is _____.

A)potassium
B)sodium
C)calcium
D)magnesium

Answer 3

magnesium

Question 4

MATCHING
Match the following drugs with their classes.
a.Neostigmine
b.Rocuronium
c.Succinylcholine
Drug used to reverse the effects of neuromuscular blocking drugs

Question 5

Which of the following can inhibit the action of ACh at the neuromuscular junction to reverse neuromuscular blockade?

A)Rocuronium
B)Succinylcholine
C)Pancuronium
D)Edrophonium

Question 6

MATCHING
Match the following drugs with their classes.
a.Neostigmine
b.Rocuronium
c.Succinylcholine
Nonpolarizing neuromuscular drugs

Question 7

The process of neuromuscular transmission begins with the release of _____ from vesicles located in the motor neuron endplate.

A)acetylcholine (ACh)
B)dopamine (DA)
C)norepinephrine (NE)
D)g-aminobutyric acid (GABA)

Question 8

After dilution,atracurium should be infused within _____ hours.

A)4
B)8
C)12
D)24

Question 9

MATCHING
Match the following drugs with their classes.
a.Neostigmine
b.Rocuronium
c.Succinylcholine
Depolarizing neuromuscular blocking drugs

Question 10

Which of the following uses of onabotulinumtoxin A is not U.S.Food and Drug Administration (FDA)approved?

A)Spasticity
B)Treatment of excessive sweating
C)Treatment of uncontrollable blinking
D)Occasional migraines

Question 11

How do neuromuscular blocking drugs work to cause muscle relaxation?

A)They block calcium channels,increasing the amount of ACh produced,which causes relaxation.
B)They increase the amount of inhibitory neurotransmitters.
C)They block all transmissions of excitement.
D)They increase the amount of inactivated ACh receptor sites.

Question 12

Which of the following is not an adverse reaction of administration of botulinum toxin type A injections?

A)Blepharoptosis
B)Muscle weakness
C)Blepharospasms
D)Headache

Question 13

Depolarizing neuromuscular drugs are _____ at _____ receptors.

A)agonists,nicotinic
B)adrenergic antagonists,muscarinic
C)adrenergic agonists,muscarinic
D)antagonists,nicotinic

Question 14

Why do nondepolarizing drugs have a longer duration of action than depolarizing drugs?

A)Nondepolarizing drugs have a higher affinity to ACh receptors.
B)The half-life is longer for nondepolarizing drugs.
C)Nondepolarizing drugs are not broken down by acetylcholinesterase.
D)Depolarizing drugs are not as easily absorbed as nondepolarizing drugs.

Question 15

With the exception of mivacurium,neuromuscular blocking agents should be stored _____.

A)at room temperature
B)in the refrigerator
C)in the freezer
D)in a warmer

Question 16

Which of the following is a nondepolarizing neuromuscular blocker?

A)Edrophonium
B)Pyridostigmine
C)Succinylcholine
D)Vecuronium

Question 17

After dilution,succinylcholine is stable at room temperature for _____ day(s).

A)1
B)2
C)3
D)4

Question 18

How does blocking calcium channels cause muscle relaxation?

A)Permits the blockage of nerve transmissions between the motor endplate and skeletal muscle receptors
B)Blocks the release of ACh
C)Promotes the binding of GABA at the neuromuscular junction,decreasing excitatory messages
D)Allows for nerve transmissions to be blocked between the spinal cord and muscles

Question 19

Drugs that decrease ACh release or deplete the neuron of ACh will also cause _____ of muscles.

A)contraction
B)stiffening
C)relaxation
D)tremor

Question 20

_____ is the only drug in the depolarizing blocker class.

A)Ethosuximide
B)Succinylcholine
C)Acetylcholine
D)Vecuronium