Deck 15: Treatment of Autoimmune Diseases That Affect the Musculoskeletal System

Question 1

Which of the following has been shown to reduce SLE flare-ups?

A)Hydroxychloroquine
B)Methylprednisolone
C)Celecoxib
D)Acetaminophen

Answer 1

Hydroxychloroquine

Question 2

Which of the following does not need to be disposed of in cytotoxic waste bags?

A)Mitoxantrone
B)Etanercept
C)Methotrexate
D)Azathioprine

Answer 2

Etanercept

Question 3

An autoimmune disease occurs when the body _____.

A)attacks the cells it is designed to protect
B)defends its own cells,thinking they are germs or a harmful substance
C)manufactures cells to replace the ones it attacked
D)creates substances that damage normal body functions

Answer 3

attacks the cells it is designed to protect

Question 4

_____ levels are elevated in people that have SLE.

A)Antinuclear antibody (ANA)
B)Monoamine oxidase (MAO)
C)Protein specific antigen
D)Adrenocorticotropic hormone

Question 5

_____ is used in the treatment of multiple sclerosis because it effectively decreases the progression of the disease.

A)Mitoxantrone
B)Hydroxychloroquine
C)Cyclosporine
D)Betamethasone

Question 6

All of the following are true about the pharmacokinetics of glucocorticoids used in the treatment of MS,myasthenia gravis,SLE,myositis,and RA except _____.

A)the ADME of glucocorticoids vary according to the dosage form administered
B)oral dosage forms are generally well absorbed in the gastrointestinal (GI)tract and are readily distributed
C)there are very few adverse effects
D)metabolism occurs in the liver

Question 7

Which of the following is not considered an autoimmune disease?

A)Myasthenia gravis
B)Multiple sclerosis (MS)
C)Osteoarthritis
D)Systemic lupus erythematosus (SLE)

Question 8

Which of the following is genetically engineered to block the inflammatory process triggered by an increased concentration of TNF?

A)Anakinra
B)Cyclosporine
C)Adalimumab
D)Methotrexate

Question 9

How does aspirin help relieve the pain associated with MS?

A)It inhibits MAO,which reduces anxiety and decreases pain perception.
B)It blocks purine synthesis,reducing the levels of pain mediators.
C)It increases streptokinase activity,which helps synthesize prostaglandins,reducing pain.
D)It blocks cyclooxygenase (COX)enzyme activity,which inhibits pain mediators.

Question 10

How do glucocorticoids help suppress the immune system?

A)They interfere with the formation of immune cells by damaging RNA and DNA needed for cell replication.
B)They inhibit the synthesis of antibodies that are responsible for attacking the body's healthy cells.
C)They increase levels of antigens in the body.
D)They increase leukocytes and T cells.

Question 11

Immunosuppressive drugs work by _____.

A)interfering with the formation of prostaglandin
B)damaging RNA and DNA needed for replication
C)forming enzymes to synthesize antigens
D)reconfiguring the cell duplication process

Question 12

In myasthenia gravis,the body attacks and destroys receptor sites in the neuromuscular junction that bind _____.

A)dopamine (DA)
B)norepinephrine (NE)
C)acetylcholine (ACh)
D)g-aminobutyric acid (GABA)

Question 13

Why would glucocorticoids be prescribed to help pain associated with RA?

A)They increase the synthesis of proinflammatory substances,which decreases pain.
B)They inhibit the synthesis of tumor necrosis factor (TNF),which is responsible for pain.
C)They increase the levels of antinuclear antibodies,reducing inflammation and pain.
D)They reduce the synthesis of prostaglandins.

Question 14

All of the following autoimmune diseases affect the muscles except _____.

A)SLE
B)dermatomyositis
C)myasthenia gravis
D)polymyositis

Question 15

Why would methylprednisolone be prescribed as an alternate day therapy?

A)To minimize adverse effects
B)Because of its long half-life
C)Because elimination is slow
D)Because it is stored in fat so the body can use it when it needs it

Question 16

Which class of medication is prescribed commonly to suppress inflammation,reduce flare-ups,and treat pain in autoimmune disorders?

A)Antibiotics
B)Glucocorticoids
C)Antivirals
D)Mineralocorticoids

Question 17

RA produces all of the following except _____.

A)pain
B)joint damage
C)muscle damage
D)inflammation

Question 18

_____ is reserved for severe,active disease of RA,SLE,MS,and myasthenia gravis.

A)Dexamethasone
B)Cyclophosphamide
C)Prednisone
D)Chloroquine

Question 19

Which of the following contains a black box warning for GI ulceration?

A)Chloroquine
B)Prednisone
C)Naproxen
D)Acetaminophen

Question 20

_____ is used to treat muscle weakness in patients with myasthenia gravis.

A)Glatiramer
B)Abatacept
C)Penicillamine
D)Neostigmine

Question 21

MATCHING
Match the following drugs with their drug classes.
a.Interleukin antagonist
b.NSAID
c.TNF inhibitor
d.Antimalarial
e.Immunosuppressive
f.Glucocorticoid
Anakinra

Question 22

MATCHING
Match the following drugs with their drug classes.
a.Interleukin antagonist
b.NSAID
c.TNF inhibitor
d.Antimalarial
e.Immunosuppressive
f.Glucocorticoid
Methylprednisolone

Question 23

MATCHING
Match the following drugs with their drug classes.
a.Interleukin antagonist
b.NSAID
c.TNF inhibitor
d.Antimalarial
e.Immunosuppressive
f.Glucocorticoid
Cyclosporine

Question 24

MATCHING
Match the following drugs with their drug classes.
a.Interleukin antagonist
b.NSAID
c.TNF inhibitor
d.Antimalarial
e.Immunosuppressive
f.Glucocorticoid
Chloroquine

Question 25

MATCHING
Match the following drugs with their drug classes.
a.Interleukin antagonist
b.NSAID
c.TNF inhibitor
d.Antimalarial
e.Immunosuppressive
f.Glucocorticoid
Etanercept

Question 26

Which of the following drugs can be used to treat spasticity in MS?

A)Infliximab
B)Carbamazepine
C)Baclofen
D)Amantadine

Question 27

MATCHING
Match the following drugs with their drug classes.
a.Interleukin antagonist
b.NSAID
c.TNF inhibitor
d.Antimalarial
e.Immunosuppressive
f.Glucocorticoid
Celecoxib