Question 1

What are Reed-Sternberg cells?&#10;A) B lymphocytes&#10;B) T lymphocytes&#10;C) Natural killer (NK) T lymphocytes&#10;D) T suppressor lymphocytes

Accepted Answer

Reed-Sternberg cells are multinucleated B lymphocyte cells.The Reed-Sternberg cell represents usually less than 1% of the cellular infiltrate in affected tissues.

Question 2

Which is the most common granular leukocyte?&#10;A) basophil&#10;B) neutrophil&#10;C) eosinophil&#10;D) monocyte

Accepted Answer

Three groups of WBCs are found in the peripheral circulation: granulocytes,lymphocytes,and monocytes.Of the granulocyte population,90% is composed of neutrophils; the remainder consists of eosinophils and basophils.Circulating lymphocytes are of three types: T lymphocytes (thymus mediated),B lymphocytes (bursa derived),and natural killer (NK)cells.

Question 3

Which of the following is the most common type of leukemia in adults?&#10;A) acute lymphocytic leukemia&#10;B) acute myelogenous leukemia&#10;C) Acute lymphocytic leukemia&#10;D) chronic lymphocytic leukemia

Accepted Answer

Chronic lymphocytic leukemia (CLL)is the most common type of leukemia in adults.The median age at diagnosis is about 72 years.CLL is very uncommon before the age of 45 and infrequent in patients under 65 years of age.It is more common in men than in women; however,5-year and 10-year survival rates are higher in women.

Question 4

Which of the following is true of acute myelogenous leukemia (AML)?&#10;A) AML is a neoplasm of mature myeloid WBCs.&#10;B) AML has a sudden onset.&#10;C) The Philadelphia chromosome is present in more than 90% of cases of AML.&#10;D) a and b&#10;E) b and c

Accepted Answer

AML is a neoplasm of myeloid (immature)WBCs,which demonstrate uncontrolled proliferation in the bone marrow space and subsequently appear in the peripheral blood.AML has a sudden onset and leads to death in 1 to 3 months if left untreated.The Philadelphia chromosome is evident in more than 90% of cases of chronic myelogenous leukemia rather than acute myelogenous leukemia.

Question 5

What is a sanctuary in relation to a patient with acute lymphoid leukemia (ALL)?&#10;A) It relates to the use of high-dose chemotherapy prior to a peripheral blood stem cell transplant.&#10;B) It is a second remission following a patient relapse.&#10;C) It is an area where chemotherapeutic agents cannot reach leukemic cells.&#10;D) It means that the number of blast cells has been reduced and the patient is in remission.

Accepted Answer

It is an area of the body where leukemic cells can migrate that chemotherapeutic agents cannot reach.The most important sanctuary in patients with ALL is the CNS.Patients with ALL are treated with systemic chemotherapy plus high-dose methotrexate intravenously and cytarabine or intrathecal methotrexate and radiation to the cranium plus high-dose systemic chemotherapy.Another important sanctuary (in males)is the testes.

Question 6

Which of the following is the most common form of leukemia among people younger than 19 years of age?&#10;A) acute lymphocytic leukemia (ALL)&#10;B) acute myelogenous leukemia (AML)&#10;C) chronic lymphocytic leukemia (CLL)&#10;D) chronic myelogenous leukemia (CML)

Accepted Answer

The most common form of leukemia among people younger than 19 years of age is acute lymphocytic leukemia (ALL).ALL accounts for 80% of leukemias in children.It accounted for about 5,330 cases in 2010.The most common types of leukemia in adults are acute myelogenous leukemia,with an estimated 12,330 new cases in 2010,and chronic lymphocytic leukemia,with some 14,990 new cases in 2010.Chronic myelogenous leukemia is estimated to have affected about 4,870 persons in 2010.

Question 7

Immunoglobulins are created by which of the following types of cells?&#10;A) T lymphocytes&#10;B) B lymphocytes&#10;C) basophils&#10;D) eosinophils

Accepted Answer

B lymphocytes play an important role in the intermediate,or humoral,immune system involving the production of plasma cells and immunoglobulins.T lymphocytes are involved with the delayed,or cellular,immune reaction.Eosinophils and basophils are involved in inflammatory allergic reactions and mediate these reactions through release of their cytoplasmic granules.

Question 8

Which of the following is/are true of Hodgkin lymphoma (HL)?&#10;A) HL is the most common neoplasm of childhood.&#10;B) The cure rate for HL is less than 10%.&#10;C) The cause of HL is unknown, but Epstein-Barr virus (EBV) is present in malignant lymphocytes in 50% of cases in the Western world.&#10;D) a and b&#10;E) b and c

Accepted Answer

EBV is present in more than 50% of cases of Hodgkin lymphoma (HL)in the Western world.Hodgkin lymphoma is the most common lymphoma in young adults.Burkitt lymphoma is the most common neoplasm of childhood.The cure rate for HL is about 90%.Relapses,if they occur,generally occur within 2 years of therapy and seldom appear after 5 years.

Question 9

What is the most prominent symptom of multiple myeloma?&#10;A) ascites&#10;B) purpura&#10;C) bone pain&#10;D) paresthesia

Accepted Answer

The most prominent feature of multiple myeloma is persistent bone pain.The sites most commonly affected are along the spine,ribs,and sternum.As bone marrow is replaced,anemia develops,along with associated features of weakness,weight loss,and recurrent infection.Headache and peripheral neuropathy are associated with hypercalcemia.

Question 10

A &#34;starry sky&#34; pattern of lymphocytes interspersed with histiocytes is associated with ________.&#10;A) multiple myeloma&#10;B) Burkitt lymphoma&#10;C) Hodgkin lymphoma&#10;D) non-Hodgkin lymphoma

Accepted Answer

The "starry sky" pattern is associated with a histologic pattern found in Burkitt lymphoma of numerous small,noncleaved,atypical B (CD10)lymphocytes interspersed with lightly stained histiocytes.Tumor cells are darkly stained and have small prominent nucleoli and a high mitotic index.

Question 11

Reed-Sternberg cells are associated with ________________.&#10;A) acute lymphocytic leukemia&#10;B) chronic lymphocytic leukemia&#10;C) Hodgkin lymphoma&#10;D) non-Hodgkin lymphoma

Accepted Answer

The answer of Reed-Sternberg cells are associated with ________________.&#10;A) acute...

Question 12

Which of the following is the prominent radiographic feature of multiple myeloma?&#10;A) &#34;hair on end&#34; pattern&#10;B) &#34;ground glass&#34; pattern&#10;C) &#34;punched out&#34; lesions&#10;D) &#34;sunburst&#34; pattern

Accepted Answer

The answer of Which of the following is the prominent...

Question 13

Which of the following is the most common intraoral location for non-Hodgkin lymphoma?&#10;A) parotid gland&#10;B) soft palate&#10;C) floor of the mouth&#10;D) posterior lateral border of the tongue

Accepted Answer

The answer of Which of the following is the most...

Question 14

What is the minimum time that should be allowed between a tooth extraction and the initiation of chemotherapy for a patient with a white blood cell disorder such as leukemia or lymphoma?&#10;A) 1 week&#10;B) 2 weeks&#10;C) 4 weeks&#10;D) 8 weeks

Accepted Answer

The answer of What is the minimum time that should...

Question 15

Which of the following is the most common type of opportunistic fungal infection in leukemic patients?&#10;A) torulopsis&#10;B) candidiasis&#10;C) aspergillosis&#10;D) mucormycosis

Accepted Answer

The answer of Which of the following is the most...

Question 16

Which of the following is a malignancy of plasma cells?&#10;A) Hodgkin lymphoma&#10;B) non-Hodgkin lymphoma&#10;C) multiple myeloma&#10;D) Burkitt lymphoma

Accepted Answer

The answer of Which of the following is a malignancy...

Question 17

Burkitt lymphoma that is found most often in Central Africa is known as ________.&#10;A) essential&#10;B) endemic&#10;C) sporadic&#10;D) idiopathic

Accepted Answer

The answer of Burkitt lymphoma that is found most often...

Deck 23: Disorders of White Blood Cells