Deck 24: Acquired Bleeding and Hypercoagulable Disorders

Question 1

Which of the following is the most popular antiplatelet drug?

A) clopidogrel
B) dipyridamole
C) eptifibatide
D) aspirin

Answer 1

aspirin

Question 2

Which of the following clinical laboratory tests is used to screen patients for thrombocytopenia?

A) PT
B) aPTT
C) TT
D) platelet count

Answer 2

platelet count

Question 3

Most bleeding disorders are ________.

A) due to a platelet deficiency
B) due to a deficiency in von Willebrand factor
C) due to Hemophilia A
D) iatrogenic

Answer 3

iatrogenic

Question 4

Which of the following medications is the best choice for postoperative pain control in a patient taking warfarin (Coumadin)?

A) celecoxib
B) acetaminophen
C) aspirin
D) ibuprofen

Question 5

Which of the following is the best laboratory test to monitor patients using warfarin?

A) BT
B) PT
C) aPTT
D) INR

Question 6

Use of which of the following medications is recommended if major surgery must be performed under emergency conditions for a patient receiving aspirin therapy?

A) ticlopidine
B) desmopressin
C) abciximab
D) tranexamic acid

Question 7

Vitamin K is needed by the liver to produce factor ___.

A) II
B) V
C) VIII
D) XI

Question 8

Tissue-type plasminogen activator (tPA)is released by _________ cells at the site of injury.

A) endothelial
B) mesenchymal
C) plasma
D) polymorphonuclear leukocytes (PMNs)

Question 9

Which of the following screening tests is used to check the extrinsic pathway (factor VII)and the common pathway (factors V and X,prothrombin,and fibrinogen)?

A) thrombin time
B) prothrombin time
C) partial thromboplastin time
D) platelet count

Question 10

Which of the following is/are true of disseminated intravascular coagulation (DIC)?

A) The most common cause of DIC worldwide is snakebite.
B) The major clinical problem with DIC is thrombosis.
C) DIC is a condition that results when the clotting system is activated in all or a major part of the vascular system.
D) a, b, and c
E) a and c

Question 11

Which of the following is the single best screening test for coagulation disorders?

A) platelet count
B) thrombin time
C) prothrombin time
D) partial thromboplastin time

Question 12

Which of the following is the most common cause of arterial thrombosis?

A) malignancy
B) atherosclerosis
C) disseminated intravascular coagulation (DIC)
D) hormonal therapy

Question 13

Which of the following three tests are recommended for use by the dentist in initial screening for possible bleeding disorders?

A) Ivy bleeding time (BT), platelet function analyzer (PFA-100), and prothrombin time (PT)
B) Ivy bleeding time (BT), prothrombin time (PT), and platelet count
C) activated partial thromboplastin time (aPTT), prothrombin time (PT), and platelet count
D) platelet function analyzer (PFA-100), activated partial thromboplastin time (aPTT), and prothrombin time (PT)

Question 14

Routine dental treatment involving minor tissue injury should be delayed if the platelet count is below _______/µL.

A) 10,000
B) 30,000
C) 50,000
D) 70,000

Question 15

Warfarin anticoagulation therapy should be continued prior to minor oral surgery and other similarly invasive dental procedures if the INR is __ or less.

A) 2.5
B) 3.5
C) 4.5
D) 5.5

Question 16

A platelet count is very effective for identifying patients who have ________.

A) von Willebrand disease
B) Glanzmann disease
C) thrombocytopenia
D) uremia

Question 17

Which of the following is/are true of platelets?

A) Platelets have a nucleus.
B) There is a reserve of platelets in the microvasculature or spleen.
C) Platelets are derived from polymorphonuclear leukocytes (PMNs).
D) a, b, and c
E) a and c

Question 18

Activation of factor ___ serves as a common link between the component parts of the homeostatic mechanism: blood coagulation,fibrinolytic,kinin,and complement systems.

A) II
B) V
C) VII
D) XII