Question 1

Which of the following symptoms is highly suggestive of severe hemophilia?&#10;A) epistaxis&#10;B) gingival bleeding&#10;C) spontaneous hemarthroses&#10;D) menorrhagia

Accepted Answer

A history of spontaneous hemarthroses and muscle hemorrhages is highly suggestive of severe hemophilia.By contrast,epistaxis,gingival bleeding,and menorrhagia are reported in patients with thrombocytopenia,platelet disorders,or von Willebrand disease.

Question 2

Which of the following correctly depicts the sequence of the three phases of hemostasis for controlling bleeding?
1.platelet
2.coagulation
3.vascular

A) 1, 2, 3
B) 2, 1, 3
C) 3, 1, 2
D) 3, 2, 1

3, 1, 2

Accepted Answer

The sequence of the three phases of hemostasis for controlling bleeding are vascular,platelet,and coagulation.The vascular and platelet phases are referred to as primary and the coagulation phase is secondary.The coagulation phase is followed by the fibrinolytic phase,during which the clot is dissolved.

Question 3

What percentage of adults with hemophilia A is HIV positive?&#10;A) 15&#10;B) 35&#10;C) 55&#10;D) 75

Accepted Answer

More than 75% of adults with hemophilia A and 45% of adults with hemophilia B are HIV positive.The long-term survival of hemophiliac patients has been greatly affected by contamination of donated blood with human immunodeficiency virus (HIV)and hepatitis C virus (HCV).HIV has tripled the death rate in hemophiliac patients and currently is responsible for more than 55% of all deaths related to hemophilia.

Question 4

What is a telangiectasia?&#10;A) a bruise&#10;B) a focal dilation of postcapillary venules with connections to dilated arterioles&#10;C) a vesiculobullous lesion&#10;D) a hyperkeratotic lesion with some dystrophic changes

Accepted Answer

Telangiectasias consist of focal dilation of postcapillary venules with connections to dilated arterioles,initially through capillaries and later directly.Perivascular mononuclear cell infiltrates also are observed.

Question 5

A female carrier of hemophilia A will transmit the disorder to ____ of her sons and the carrier trait to _____ of her daughters.&#10;A) half; half&#10;B) none; half&#10;C) half; none&#10;D) none; none

Accepted Answer

A female carrier will trAnswermit the disorder to half of her sons and the carrier state to half of her daughters.Hemophilia A is inherited as an X-linked recessive trait.An affected man will not trAnswermit the disease to his sons; however,all of his daughters will be carriers of the trait because they inherit his X chromosome.

Question 6

Which of the following is an inherited platelet disorder?&#10;A) Ehlers-Danlos disease&#10;B) Bernard-Soulier disease&#10;C) Christmas disease&#10;D) Osler-Weber-Rendu syndrome

Accepted Answer

The two most common hereditary platelet function disorders (HPFDs)are Bernard-Soulier syndrome and Glanzmann thrombasthenia.Other HPFDs include an abnormal alpha granule formation,as in the gray platelet syndrome (with marrow myelofibrosis),and of organelle biogenesis in the HermAnswerky-Pudlak and Chédiak-Higashi syndromes,where platelet-dense body defects are linked to abnormalities of other lysosome-like organelles including melanosomes.

Question 7

Which of the following blood tests is used to measure the status of the intrinsic and common pathways of coagulation?&#10;A) platelet count&#10;B) aPTT&#10;C) PT&#10;D) TT

Accepted Answer

The aPTT test is used to measure the status of the intrinsic and common pathways of coagulation.The platelet count is used to screen for thrombocytopenia.

Question 8

Hemophilia A may be observed in the daughter of (a/an)___________ male and (a/an)___________ female.&#10;A) affected; affected&#10;B) affected; carrier&#10;C) carrier; affected&#10;D) carrier; carrier

Accepted Answer

Hemophilia can manifest in women when there is a mating between an affected male and a carrier female.One-half of the daughters of such a mating would inherit two abnormal X chromosomes-one from the affected father and one from the carrier mother.These daughters would have homozygous hemophilia.In addition,hemophilia may occur in a minority of heterozygous carriers.Rare cases of hemophilia in females have been attributed to a newly mutant gene.

Question 9

Which of the following is the most common inherited bleeding disorder?&#10;A) hemophilia A&#10;B) hemophilia B&#10;C) von Willebrand disease&#10;D) Bernard-Soulier disease

Accepted Answer

The most common inherited bleeding disorder is von Willebrand disease.It affects 1% of the U.S.population.The disease usually is inherited as an autosomal dominant trait.Hemophilia A,factor VIII deficiency,is the most common of the inherited coagulation bleeding disorders.

Question 10

von Willebrand factor (vWF)is needed to ________________.&#10;A) preserve the integrity of the capillary vessel wall&#10;B) catalyze the fibrinolytic phase of clot lysis&#10;C) attach platelets to damaged vascular wall tissues and to carry factor VIII in circulation&#10;D) stimulate formation of platelets

Accepted Answer

In von Willebrand disease,the primary problem involves lack of various sizes of von Willebrand factor (vWF),which are needed to attach platelets to damaged vascular wall tissues and to carry factor VIII in circulation.In the most severe form of the disease,bleeding occurs as a consequence of lack of platelet adhesion and deficiency of factor VIII.

Question 11

Hemophilia A is caused by a deficiency or a defect of factor ____.&#10;A) VII&#10;B) VIII&#10;C) IX&#10;D) XI

Accepted Answer

The answer of Hemophilia A is caused by a deficiency...

Question 12

Which of the following dental treatments for a patient with severe hemophilia A will usually require factor VIII replacement therapy?&#10;A) infiltration anesthesia&#10;B) block anesthesia&#10;C) simple restorative procedures&#10;D) conservative periodontal procedures

Accepted Answer

The answer of Which of the following dental treatments for...

Deck 25: Congenital Bleeding and Hypercoagulable Disorders