Deck 24: The Metabolism of Membrane Lipids

Question 1

The alleles in the ABO blood group system code for:

A)Integral membrane proteins.
B)Glycosyl transferases.
C)Peripheral membrane proteins.
D)Cytoskeletal proteins.
E)Phosphoglyceride-synthesizing enzymes.

Answer 1

Glycosyl transferases.

Question 2

A 5-year-old girl presents with hepatosplenomegaly, abnormal bleeding, defects in long bone development, and neurological dysfunction.A liver biopsy reveals an accumulation of glucocerebroside.These symptoms indicate the child is suffering from:

A)Fabry disease.
B)Niemann-Pick disease.
C)Krabbe disease.
D)Gaucher disease.
E)Hurler syndrome.

Answer 2

Gaucher disease.

Question 3

A pregnant woman mentions that 2 years ago, her first child died 2 weeks after birth because the newborn's "lungs were immature" at birth.Because you are planning a cesarean section, you want to determine first whether there is a risk of respiratory problems for her current baby.Which of the following results from an analysis of the mother's amniotic fluid would indicate a high risk?

A)A low ratio of free cholesterol/cholesterol esters.
B)An elevated glucose level.
C)A low lecithin/sphingomyelin ratio.
D)An elevated level of phosphatidylglycerol.
E)A reduced level of platelet-activating factor.

Answer 3

A low lecithin/sphingomyelin ratio.

Question 4

One per 30 Ashkenazi Jews carries a mutation for Tay-Sachs disease in the heterozygous state.The heterozygotes can be identified by measuring one of the following enzymes in cultured leucocytes:

A)Glucocerebrosidase.
B)Hexosaminidase A.
C)Iduronate sulfatase.
D)Ceramidase.
E)ẞ-Galactosidase.