Deck 13: Neuromuscular Blockade

Question 1

Which of the following uses of botulinum toxin type A is FDA approved?

A)cosmetic use to temporarily remove wrinkles
B)treatment of excessive sweating
C)treatment of uncontrollable blinking
D)a and b

Answer 1

D
Botulinum toxin type A,commonly known as Botox,is a neuromuscular blocking drug.Its use is becoming widespread,and it has been FDA approved for a variety of conditions,including cosmetic use to temporarily remove wrinkles and treatment of excessive sweating.It has been administered for treatment of uncontrollable blinking and spasticity associated with cerebral palsy;however,this use is not FDA approved.

Question 2

MATCHING
Match the following drugs with their classes.
a.neostigmine
b.doxacurium
c.succinylcholine
depolarizing neuromuscular blocking drugs

Answer 2

C

Question 3

_____ is the only drug in the depolarizing blocker class

A)Ethosuximide
B)Succinylcholine
C)Acetylcholine
D)Mysoline

Answer 3

B
Succinylcholine is the only drug in the class of depolarizing blockers.

Question 4

Drugs that decrease acetylcholine (ACh)release or deplete the neuron of ACh will also cause _____ of muscles.

A)contraction
B)stiffening
C)relaxation
D)tremor

Question 5

The process of neuromuscular transmission begins with the release of _____ from vesicles located in the motor neuron endplate

A)acetylcholine
B)anticholinesterase
C)norepinephrine
D)GABA

Question 6

_____ neuromuscular blockers are drugs that act as agonists at acetylcholine receptor sites and produce sustained depolarization;causing the receptors to convert to an inactive state.

A)Polarizing
B)Eepolarizing
C)Neutralizing
D)None of the above

Question 7

Most neuromuscular blocking drugs are poorly absorbed from the gastrointestinal tract;therefore,they are administered ____.

A)topically
B)parenterally
C)transdermally
D)a and c

Question 8

What drugs should be administered with neuromuscular blocking drugs during surgery?

A)Antianxiety
B)Analgesics
C)CNS depressants
D)Any of the above

Question 9

MATCHING
Match the following drugs with their classes.
a.neostigmine
b.doxacurium
c.succinylcholine
drugs used to reverse the effects of neuromuscular blocking drugs

Question 10

MATCHING
Match the following drugs with their classes.
a.neostigmine
b.doxacurium
c.succinylcholine
nonpolarizing neuromuscular drugs

Question 11

Depolarizing neuromuscular drugs are _____ at _____ receptors.

A)agonists,nicotinic
B)antagonists adrenergic,muscarinic
C)agonists adrenergic,muscarinic
D)antagonists,nicotinic

Question 12

Which of the following is not an adverse reaction of administration of botulinum toxin type A injections?

A)droopy eyelid muscles (blepharoptosis)
B)muscle weakness
C)spasms of the eyelids (blepharospasms)
D)headache

Question 13

An examples of a drug or substance that decreases acetylcholine (Ach)release is(are)_____.

A)botulinum toxin
B)magnesium
C)calcium
D)a and b

Question 14

Common endings for nondepolarizing neuromuscular blocker drugs are _____.

A)"-curare"
B)"-curonium"
C)"-curium"
D)b and c