Deck 6: Other Blood Group Systems

Question 1

Lewis system antibodies have not been implicated in hemolytic disease of the fetus and newborn because:

A)the antigens are not fully developed at birth.
B)Lewis system antibodies do not cross the placenta.
C)the antibodies are not clinically significant.
D)all of the above are correct.

Answer 1

D
Lewis antibodies are often found during pregnancy but do not cross the placenta because they are IgM.The antigens are not well developed at birth.

Question 2

An antibody to Js^b was identified in a patient scheduled for elective surgery at a later date.What is the best approach to finding compatible blood?

A)Contact the rare donor registry since Js^b negative units are rare.
B)Request that family members be tested to determine if they share the same phenotype.
C)Screen donors from the black population since being Js^b negative is common in blacks.
D)A and B are correct.

Answer 2

D
Js^b-negative individuals are less than 1% of the black population and even rarer in the white donor population.The rare donor registry is the most likely source of units;however,they would probably be stored as frozen red cells.Since the units are not required urgently,family members should be typed to potentially locate compatible blood.

Question 3

Antigens of the P system are structurally related to which of the following blood group systems?

A)MNS
B)ABH
C)Kell
D)Duffy

Answer 3

B
The P system antigens are formed by the action of glycosyltransferases,similar to the ABO system genes and antigen products.

Question 4

K1-positive donor red cells were mistakenly transfused to a recipient with anti-K.The patient's posttransfusion blood sample has a positive direct antiglobulin test with polyspecific antihuman globulin.The direct antiglobulin test is positive because anti-K is an __________ antibody that has sensitized the __________ cells in vivo.

A)IgG,donor's
B)IgM,donor's
C)IgG,recipient's
D)IgM,recipient's

Question 5

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
Antigen has a higher frequency in females

Question 6

Antibodies to which of the following blood group system show dosage (i.e. ,are stronger with homozygous expression of the antigen)?

A)Lutheran
B)P
C)Duffy
D)Kell

Question 7

All the following statements are true regarding Lewis system antibodies except antibodies:

A)may be observed at the immediate spin,37° C,and antihuman globulin phases.
B)can be neutralized by Lewis substance.
C)may cause hemolysis in vitro.
D)do not react following enzyme treatment of cells.

Question 8

Which of the following facts is not a characteristic of Kell system antibodies?

A)Usually clinically significant IgG antibodies
B)Best detected in indirect antiglobulin test phases
C)Lose reactivity with proteolytic enzyme reagents
D)Do not bind complement proteins

Question 9

Antibodies to Kidd,Kell,and Duffy blood group antigens share all the following characteristics except:

A)can cause hemolytic disease of the newborn.
B)usually detected only by the indirect antiglobulin test.
C)enhanced with enzyme treatment.
D)can cause transfusion reactions.

Question 10

Red cells that phenotype as S-s- are also:

A)M-negative.
B)N-negative.
C)Tj^a-negative.
D)U-negative.

Question 11

A patient's antibody history listed an anti-cellano.This antigen is also known as:

A)c in the Rh system.
B)k in the Kell system.
C)Cs in the Cost system.
D)SC in the Scianna system.

Question 12

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
Antigen of high incidence;antibody to it can cause hemolytic transfusion reactions

Question 13

Antibodies to Lu^b antigen are not commonly detected because:

A)Lu^b antigen is of high incidence.
B)the antibodies do not cause transfusion reactions.
C)Lu^b antigen is not present on screening cells.
D)the antibodies react best at 4° C.

Question 14

The following statements regarding anti-P₁ are true except:

A)anti-P₁ will not react with enzyme-treated P₁ positive red cells.
B)P₂ individuals can make anti-P_1.
C)anti-P₁ is clinically not significant.
D)anti-P₁ reacts best at room temperature.

Question 15

If all red cells tested at room temperature are positive with a patient's serum except for cord cells,the probable antibody identity is:

A)anti-Lu.
B)anti-Le^a.
C)anti-I.
D)anti-M.

Question 16

Which condition is often associated with the presence of anti-I?

A)Infectious mononucleosis
B)Mycoplasma pneumoniae infection
C)Pregnancy
D)Colon cancer

Question 17

A person who inherits the Le,Se,and H genes will have red cells that phenotype:

A)Le(a+b+).
B)Le(a-b+).
C)Le(a-b-).
D)Le(a+b-).

Question 18

Which of the following phenotypes is heterozygous?

A)Fy(a-b+)
B)Jk(a+b-)
C)Fy(a+b+)
D)Le(a+b-)

Question 19

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
Antibodies are sensitive to enzymes and have high-titer low-avidity characteristics

Question 20

The Donath-Landsteiner antibody is:

A)an IgG auto anti-P.
B)an IgM auto anti-I.
C)anti-IH that reacts at cold temperatures.
D)IgG anti-p^k.

Question 21

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
Antibody to this antigen demonstrates weak mixed field reaction

Question 22

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
Antibodies in this system often fall below detectable levels and are associated with delayed transfusion reactions

Question 23

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
Antigens Yt^a and Yt^b are in this system

Question 24

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
System associated with McLeod phenotype

Question 25

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
System associated with glycophorin A and B

Question 26

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
System associated with chronic granulomatous disease

Question 27

Match each characteristic with the appropriate blood group system.A selection may be used more than once.a.Cartwright
b.MNSs
c.Kidd
d.Vel
e.Xg^a
f.Sd^a antigen
g.Chido/Rodgers
h.Kell
i.Duffy
System associated with resistance to malaria