Question 1

Deficiency for which of the following causes severe combined immunodeficiency syndrome?&#10;A) Rhesus factor&#10;B) Adenosine deaminase&#10;C) WAS&#10;D) CD69&#10;E) CYP21

Accepted Answer

Adenosine deaminase (ADA) deficiency results in severe combined immunodeficiency syndrome (SCID), a condition in which both T and B cells are severely compromised, leading to recurrent infections and failure to thrive. The other options listed do not directly cause SCID.

Question 2

For which of the following tissues is homograft rejection not an issue?&#10;A) Bone marrow&#10;B) Liver&#10;C) Kidney&#10;D) Heart&#10;E) Cornea

Accepted Answer

Corneal transplants generally do not face issues with homograft rejection because the cornea is avascular (lacks blood vessels), which significantly reduces the immune response against the transplanted tissue.

Question 3

Which of the following processes is involved in immunoglobulin gene rearrangement?&#10;A) Meiotic recombination&#10;B) Somatic recombination&#10;C) Nonhomologous end joining&#10;D) Gene synapsis&#10;E) Diakinesis

Accepted Answer

Immunoglobulin gene rearrangement involves the process of somatic recombination, where segments of DNA are rearranged to create a unique antibody gene sequence. Meiotic recombination occurs during meiosis to create genetic diversity in gametes. Nonhomologous end joining occurs during DNA damage repair. Gene synapsis occurs during prophase I of meiosis. Diakinesis is a stage of meiosis where the chromosomes become condensed and homologous pairs separate.

Deck 13: Immunogenetics