Deck 50: Antifungal Agents

Question 1

One class of antifungal drugs inhibits glucan synthesis, thereby blocking production of the major structural component of the fungal cell wall. Which of the following drugs has this mechanism of action?

A) Polyenes
B) Azoles
C) Triazoles
D) Echinocandins
E) Griseofulvin

Answer 1

Echinocandins

Question 2

Amphotericin B is most commonly associated with the following adverse effect:

A) Gastric hemorrhage
B) Renal toxicity
C) Pulmonary fibrosis
D) Thyroid dysfunction
E) Congestive heart failure

Answer 2

Renal toxicity

Question 3

Ketoconazole is of the azole class of antifungal medications. What is its mechanism of action?

A) Inhibits mitosis
B) Inhibit DNA synthesis
C) Bind to sterols in the cell membrane
D) Inhibit synthesis of membrane sterols
E) Inhibits ribosomal protein translation

Answer 3

Inhibit synthesis of membrane sterols