Deck 3: Clinical Pharmacokinetics and Issues in Therapeutics

Question 1

For a 40-year-old, 75-kg man, drug X has a volume of distribution of 40 L and a clearance of 25 ml/min. Calculate the predicted loading dose of drug X to achieve a plasma concentration of 2 μg/ml.

A) 20 μg
B) 80 μg
C) 20 mg
D) 50 mg
E) 80 mg

Answer 1

80 mg

Question 2

Which of the following is most likely increased in the average 70-year-old man compared with the average 30-year-old man?

A) Body water percentage
B) Total lean body mass
C) Glomerular filtration rate
D) Carotid body baroceptor reflex
E) Plasma α-1 acid glycoprotein

Answer 2

Plasma α-1 acid glycoprotein

Question 3

Ketamine has a half-life of 2 ½ hours. If used as a continuous infusion at a dosage of 12.5 mg/hr for postoperative pain relief, how long will it take to achieve a practical steady-state concentration?

A) 5 hours
B) 7 ½ hours
C) 10 hours
D) 12 ½ hours
E) 15 hours

Answer 3

12 ½ hours