Deck 12: Introduction to Hemostasis

Question 1

The appropriate anticoagulant for prothrombin time assay is:

A) EDTA.
B) 3.2% sodium citrate.
C) 3.8% sodium citrate.
D) heparin.

Answer 1

3.2% sodium citrate.

Question 2

The final result of secondary hemostasis is:

A) platelet plug.
B) constriction of a blood vessel.
C) a blood clot.
D) promotion of bleeding to cleanse a wound.

Answer 2

a blood clot.

Question 3

The final result of primary hemostasis is:

A) platelet plug.
B) constriction of a blood vessel.
C) a blood clot.
D) promotion of bleeding to cleanse a wound.

Answer 3

platelet plug.

Question 4

The protein "glue" that optimally binds platelets and collagen after vessel injury is:

A) fibronectin.
B) von Willebrand's Factor (VIII:vWF).
C) factor II.
D) factor I.

Question 5

MATCHING
Match the following coagulation factors with the appropriate description (use an answer only once).
factor II

A)prothrombin
B)hemophilia B
C)von Willebrand's factor
D)fibrinogen

Question 6

A function or activity of platelets is to help activate and be a participant in plasma coagulation.

Question 7

Natural anticoagulants include:

A) antithrombin III (AT-III).
B) protein C.
C) protein S.
D) all of the above.

Question 8

The final end product of fibrinolysis is:

A) fibrinogen.
B) fibrin.
C) fibrin-split products.
D) plasmin.

Question 9

A function or activity of platelets is to secrete fibronectin.

Question 10

A prothrombin time assay should be conducted within ____ hours after specimen collection.

A) 2
B) 4
C) 8
D) 24

Question 11

MATCHING
Match the following coagulation factors with the appropriate description (use an answer only once).
factor I

A)prothrombin
B)hemophilia B
C)von Willebrand's factor
D)fibrinogen

Question 12

D-dimer assay is important in detecting:

A) factor VIII deficiency.
B) disseminated intravascular coagulation (DIC).
C) fibrinogen deficiency.
D) defective platelet aggregation.

Question 13

In the activated partial thromboplastin time (APTT),calcium chloride is mixed with:

A) kaolin.
B) phospholipid component of thromboplastin.
C) platelets.
D) phospholipids component of thrombin.

Question 14

A function or activity of platelets is to form an aggregate plug or platelet mass that can physically slow down or stop blood loss.

Question 15

An unbalanced hemostatic mechanism can produce:

A) thrombosis.
B) bleeding.
C) inadequate number of platelets.
D) both a and b.

Question 16

MATCHING
Match the following coagulation factors with the appropriate description (use an answer only once).
factor VIII

A)prothrombin
B)hemophilia B
C)von Willebrand's factor
D)fibrinogen

Question 17

A function or activity of platelets is to maintain the endothelial lining of the blood vessels.

Question 18

The formation of a blood clot relies on three major steps in which order?

A) Formation of thromboplastin, formation of thrombin, and formation of fibrin
B) Formation of thrombin, formation of thromboplastin, and formation of fibrin
C) Formation of fibrin, formation of thrombin, and formation of thromboplastin
D) Formation of fibrin, formation of thromboplastin, and formation of thrombin

Question 19

A function or activity of platelets is to contain PF3 on or within the plasma membrane of the platelets.

Question 20

Most patients on warfarin therapy should maintain an international normalized ratio (INR)of approximately ____ times of a normal value.

A) 0.5-1.5
B) 1-2
C) 2-3
D) 3-4

Question 21

Match the three groups of coagulation factors based on their properties.
prothrombin group

A)factors II, VII, IX, and X
B)factors XI and XII, prekallikrein (Fletcher factor), and HMWK (Fitzgerald factor)
C)factors I, V, VIII, and XIII

Question 22

MATCHING
Match the following coagulation factors with the appropriate description (use an answer only once).
factor IX

A)prothrombin
B)hemophilia B
C)von Willebrand's factor
D)fibrinogen

Question 23

Match the three groups of coagulation factors based on their properties.
contact group

A)factors II, VII, IX, and X
B)factors XI and XII, prekallikrein (Fletcher factor), and HMWK (Fitzgerald factor)
C)factors I, V, VIII, and XIII

Question 24

Match the pathway with the appropriate description.
intrinsic pathway

A)It is thought that tissue injury, following exposure to foreign substances such as collagen, activates the pathway.
B)The pathway taken when tissue thromboplastin, a substance not found in the blood, enters the vascular system and, in the presence of calcium and factor VII, activates factor X.

Question 25

Match the pathway with the appropriate description.
extrinsic pathway

A)It is thought that tissue injury, following exposure to foreign substances such as collagen, activates the pathway.
B)The pathway taken when tissue thromboplastin, a substance not found in the blood, enters the vascular system and, in the presence of calcium and factor VII, activates factor X.

Question 26

Match the three groups of coagulation factors based on their properties.
fibrinogen group

A)factors II, VII, IX, and X
B)factors XI and XII, prekallikrein (Fletcher factor), and HMWK (Fitzgerald factor)
C)factors I, V, VIII, and XIII