Question 1

This medium power photomicrograph of a small artery depicts the results of which one of the following pathophysiologic events?  &#10;A)Atherosclerosis&#10;B)Fracture of a long bone&#10;C)Organisation&#10;D)Recanalisation&#10;E)Therapeutic embolisation &#10;F)Thromboembolism

Accepted Answer

This artery shows the continuum endpoint of the organisation of a thrombus,with new vessel formation (V).We call this event "recanalisation".

Question 2

The accompanying low power photomicrograph of the left ventricle shows a thrombus (T)in the heart of a 66 year old man who died of a heart attack.Which one of the following factors most likely explains the underlying pathophysiologic reason for a thrombus to occur in this area?

A)Endocardial (endothelial)damage
B)Hypercoagulability
C)Hypertension
D)Inflammation
E)Vasospasm

Endocardial (endothelial)damage

Accepted Answer

It is likely that the myocardial infarction injured the endocardial surface,which promoted thrombus formation.

Question 3

The three major factors,often referred to as &#34;Virchow's triad&#34; that predispose patients to thrombosis consists of which one of the following groups?&#10;A)Altered blood flow,endothelial damage,and hypercoagulability&#10;B)Female gender,birth control pills,and smoking&#10;C)Fever,obesity,and smoking&#10;D)Male gender,obesity,and smoking

Accepted Answer

Virchow's triad refers to altered blood flow (turbulence or stagnation),endothelial damage,and hypercoagulability (from whatever cause).

Question 4

This low power photomicrograph of the lung shows a thromboembolism within a pulmonary artery.What is the most likely source for this thrombus?  &#10;A)Deep leg veins&#10;B)Left atrium&#10;C)Left ventricle&#10;D)Likely formed in situ on top of an atherosclerotic plaque&#10;E)Right atrium &#10;F)Right ventricle&#10;G)Vena cava

Accepted Answer

Complicated atherosclerotic plaques with overlying thrombosis are rare in the pulmonary circulation.However,the deep veins of the pelvis and leg are often involved by venous thrombi,which commonly dislodge,are pumped through the right side of the heart,and end up wedged in one or more branches of the pulmonary arteries.Large thrombi can occlude the main pulmonary artery,causing instant right heart failure,and/or ventricular fibrillation.

Question 5

This medium power photomicrograph of a small artery depicts the result of which one of the following pathophysiologic events?  &#10;A)Atherosclerosis&#10;B)Fracture of a long bone&#10;C)Organisation&#10;D)Recanalisation&#10;E)Therapeutic embolisation &#10;F)Thromboembolism

Accepted Answer

Organisation of a thrombus,in the form of granulation tissue (G)is seen in this photomicrograph.There is a portion of thrombus (T)that has not yet been organiseD

Question 6

The accompanying photomicrograph shows alternating layers of a thrombus.This layering effect is known by which one of the following terms?  &#10;A)Alternating current&#10;B)Bilayer cementing&#10;C)Lines of Zahn&#10;D)Zebra stripes

Accepted Answer

The layering is known as the Lines of Zahn.

Question 7

This medium power photomicrograph of a small artery likely depicts the result of which one of the following pathophysiologic events?  &#10;A)Atherosclerosis&#10;B)Fracture of a long bone&#10;C)Organisation&#10;D)Recanalisation&#10;E)Therapeutic embolisation &#10;F)Thromboembolism

Accepted Answer

Fracture of a long bone may lead to embolisation of the bone marrow (as in this case)and also fat.Both can lodge within arteries and cause hypoxia and ischaemiA

Deck 9: Thrombosis and Embolism