Deck 22: Chemotherapy Drugs

Question 1

Which of the following endings is common to generic purine analog chemotherapy drugs?

A) -rabine
B) -poside
C) -ribine
D) A and C

Answer 1

A and C

Question 2

Gonadotropin-releasing hormone (GnRH)chemotherapy drugs block GnRH receptors on the anterior pituitary gland,so that the anterior pituitary gland does not secrete ________.

A) estradiol
B) luteinizing hormone
C) progesterone
D) testosterone

Answer 2

luteinizing hormone

Question 3

Androgen hormone chemotherapy drugs are used to treat ________.

A) breast cancer in females
B) prostate gland cancer in men
C) leukemia in both men and women
D) all of the above

Answer 3

breast cancer in females

Question 4

In order to treat cancer,the physician must ________.

A) determine the type of cancer
B) determine the stage of the cancer
C) wait for a remission
D) A and B

Question 5

The first chemotherapy drug was ________.

A) nitrogen mustard
B) methotrexate
C) cisplatin
D) interferon

Question 6

Select the statement that is FALSE.

A) Chemotherapy drugs often cause nausea and vomiting.
B) Nitrogen mustard gas was first used in chemical warfare.
C) Some chemotherapy drugs come from the periwinkle plant.
D) Interferon is released when the cell is invaded by cancer.

Question 7

Which of the following is NOT one of the three categories of antimetabolite chemotherapy drugs?

A) folic acid blocker chemotherapy drugs
B) nitrosourea chemotherapy drugs
C) purine analog chemotherapy drugs
D) pyrimidine analog chemotherapy drugs

Question 8

Immunomodulator chemotherapy drugs modulate or regulate ________.

A) antigens involved in the differentiation of cells
B) DNA and/or RNA
C) receptors on the cell wall of cancer cells
D) the immune system so that it can kill cancer cells.

Question 9

Antimetabolite chemotherapy drugs act in all of the following ways,EXCEPT ________.

A) take the place of purine in a cancer cell's DNA
B) bind to antigens on the surface of cancer cells
C) interfere with the role that folic plays in cell metabolism
D) take the place of pyrimidine so the cancer cell cannot build DNA

Question 10

Which of the following does NOT belong to the drug category of mitosis inhibitor chemotherapy drugs?

A) podophyllotoxin chemotherapy drugs
B) kinase inhibitor chemotherapy drugs
C) topoisomerase chemotherapy drugs
D) vinca alkaloid chemotherapy drugs

Question 11

Anti-androgen hormone chemotherapy drugs bind to and block receptors in ________.

A) breast tissue
B) liver tissue
C) lung tissue
D) prostate gland tissue

Question 12

Which chemotherapy drug is structurally related to vitamin A?

A) immunomodulator chemotherapy drugs
B) corticosteroid drugs
C) monoclonal antibody drugs
D) retinoid and rexinoid chemotherapy drugs

Question 13

Which of these drug categories is created using recombinant DNA technology?

A) Platinum chemotherapy drugs
B) Monoclonal antibody chemotherapy drugs
C) Granulocyte colony-stimulating factor drugs
D) B and C

Question 14

Chemotherapy enzyme drugs are used to treat ________.

A) breast cancer in females
B) all types of cancer
C) leukemia
D) testicular cancer in men

Question 15

The selection of an appropriate chemotherapy drug is based on ________.

A) the type of cancer
B) the stage of the cancer
C) the type of cancer and the stage of the cancer
D) where the cancer is located

Question 16

The drug epoetin alfa (Epogen,Procrit)is used to stimulate the production of ________ in patients with cancer.

A) white blood cells
B) interferon
C) nitrogen mustard
D) red blood cells

Question 17

All of the following are examples of chemotherapy antibiotic drugs,EXCEPT ________.

A) conjugated estrogens (Premarin)
B) bleomycin
C) doxorubicin (Adriamycin)
D) dactinomycin (Cosmegen)

Question 18

Platinum chemotherapy drugs contain the precious metal platinum that ________.

A) binds to tubulin in the microtubules
B) changes folic acid into a metabolite
C) creates cross-links in DNA strands
D) interferes with cellular metabolism

Question 19

To kill cancer cells,alkylating chemotherapy drugs cause alkylation,a chemical reaction in which an alkyl group ________.

A) allows microtubules to form but not function properly
B) binds to antigens on the surface of cancer cells
C) is substituted for a hydrogen molecule in the DNA of a cancer cell
D) inhibits the release of hormones to create an environment where cancer cells cannot grow

Question 20

Select the statement that is FALSE.

A) Chemotherapy protocols are designated by acronyms.
B) A remission occurs when cancer cells stop reproducing.
C) Corticosteroids are a chemotherapy drugs.
D) Certain cancers come from tissues that are influenced by the female hormones estradiol and progesterone.

Question 21

All of the following are categories of hormone chemotherapy drugs,EXCEPT ________.

A) aromatase inhibitor
B) anti-androgen
C) progestin
D) demethylating

Question 22

Mitosis inhibitor drugs affect dividing cells and keep them from completing the process of cell division.

Question 23

Which of the following is a pyrimidine analog chemotherapy drug?

A) capecitabine (Xeloda)
B) mechlorethamine (Mustargen)
C) doxorubicin (Adriamycin)
D) testosterone (Delatestryl)

Question 24

Which of the following statements is FALSE?

A) Platinum is a precious metal that is mostly mined in South Africa.
B) Interleukin is released when a cell is invaded by a virus.
C) Chemotherapy enzyme drugs are enzymes that break down the amino acid asparagine.
D) There are vitamin A receptors on cancer cells and retinoid chemotherapy drugs bind to them.

Question 25

Adjuvant therapy ________.

A) can include chemotherapy or radiation therapy
B) helps to eradicate any remaining tumor cells
C) is given after surgery to remove a tumor
D) all of the above

Question 26

Purine is a molecule that forms the base for the amino acids adenine and guanine in the DNA molecule.

Question 27

Podophyllotoxin chemotherapy drugs are derived from ________.

A) the soil
B) the root of the Mayapple plant
C) folic acid
D) a drug used for chemical warfare

Question 28

Some cancers have receptors on the surface of their cells that are stimulated by ________.

A) radiation
B) mitosis
C) hormones
D) microtubules

Question 29

Vinca alkaloid chemotherapy drugs ________.

A) bind to tubulin in the microtubules
B) are derived from the periwinkle plant
C) are used to treat different kinds of cancer
D) all of the above

Question 30

Folic acid blocker chemotherapy drugs act as an antagonist in that they complete with folic acid for the same enzyme.

Question 31

Corticosteroid drugs are given to decrease the tissue inflammation caused by chemotherapy drugs.

Question 32

Which of the following statements is FALSE?

A) The stage of the cancer indicates whether the cancer has spread beyond the original or primary site and metastasized to secondary sites.
B) Uncontrolled cell division and metastasis are identifying characteristics of cancer cells.
C) Benign and malignant neoplasms are classified as cancer.
D) A treatment that is appropriate for one type of cancer is usually not appropriate for a different type of cancer.

Question 33

During treatment with chemotherapy drugs,________.

A) a cancer patient can experience a complete remission
B) the tumor can increase in size and form new metastatic lesions
C) the patient is given palliative care
D) A and B

Question 34

Cancers that arise from tissue that is influenced by a male or female sex hormone are treated with a chemotherapy drug that has the same hormonal effect.

Question 35

Androgen hormone drugs are used to treat breast cancer because they stimulate estradiol receptors in breast tissue.

Question 36

The well-known generic chemotherapy antibiotic drug doxorubicin is related to the trade name drug ________.

A) it has no trade name associated with it.
B) Adriamycin
C) Leukeran
D) Myleran

Question 37

Which of the following drugs belong to the category of hormone chemotherapy drugs?

A) estrogen chemotherapy drugs
B) androgen chemotherapy drugs
C) selective estrogen receptor modulator
D) all of the above

Question 38

Palliative care for cancer patients includes all of the following,EXCEPT ________.

A) chemotherapy drugs
B) analgesic drugs and pain management
C) counseling
D) emotional support

Question 39

All of the following are nitrosourea chemotherapy drugs,EXCEPT ________.

A) carmustine (BiCNU, Gliadel)
B) lomustine (CeeNU)
C) streptozocin (Zanosar)
D) bicalutamide (Casodex)

Question 40

Which of the following statements is FALSE?

A) A remission occurs when cancer cells stop actively reproducing.
B) All patients have a complete remission following chemotherapy.
C) If the tumor increased in size while the patient was being treated, this is called failed chemotherapy.
D) If a patient fails chemotherapy, the physician will try a new combination of chemotherapy drugs.

Question 41

A/an ________ is a drug that is created by slightly modifying the molecular structure of another substance.

Question 42

The pyrimidine analog chemotherapy drug cytarabine was developed from a substance found in Caribbean sea sponges.

Question 43

Chemotherapy drugs target rapidly dividing cancer cells.However,their effects are also felt in other areas where cells normally divide rapidly,such as in the mucous membranes.

Question 44

Chemotherapy antibiotic drugs are used to treat cancer and are also used to bacterial infections as regular antibiotic drugs.

Question 45

The ending -lutaminde is common to anti-________ hormone chemotherapy drugs.

Question 46

Nitrosourea chemotherapy drugs contain molecules of nitroso and urea.

Question 47

Leucovorin rescue occurs before methotrexate chemotherapy.

Question 48

Interleukin chemotherapy drugs are only used to treat leukemia.

Question 49

Estrogen hormone chemotherapy drugs are used to provide ________ treatment for advanced breast cancer and/or advanced prostatic cancer; this is a treatment that provides relief from symptoms but is not intended to cure.

Question 50

Monoclonal antibody drugs selectively bind to specific antigens on the surface of cancer cell walls.

Question 51

Interleukin stimulates lymphocytes to attack cancer cells.

Question 52

Drugs used to treat cancers or malignant neoplasms are chemotherapy drugs and are also known as ________ drugs.

Question 53

The extent of cancer progression is referred to as the stage.

Question 54

A neoplasm is a new growth of cells that may be ________ or malignant.

Question 55

The ending -platin is common to generic platinum chemotherapy drugs.

Question 56

The well-known generic pyrimidine analog chemotherapy drug capecitabine is related to the trade name drug Xeloda.

Question 57

When a patient receives a chemotherapy drug that is known to be toxic to a particular organ,the patient is also given a drug to protect that organ from toxicity.This drug exerts a ________ effect to protect that organ.

Question 58

Corticosteroid drugs are used to treat anemia caused by chemotherapy drugs.

Question 59

Mesna protects the ________ from toxicity due to the chemotherapy drug ifosfamide.

Question 60

Chemotherapy drugs are most effective when begun when there are many cancer cells present in the body.

Question 61

Docetaxel (Taxotere)belongs to the category of ________ chemotherapy drugs.

Question 62

Folic acid is a ________ vitamin whose metabolite is important in DNA production in the cell.

Question 63

Cancer is a Latin word meaning crab.Explain how cancer resembles a crab.

Question 64

Match the drug name in Column 1 with the drug category in Column 2.

A)folic acid blocker chemotherapy drug
B)antiemetic drug used with chemotherapy
C)granulocyte-colony stimulator factor drug
D)gonadotropin-releasing hormone chemotherapy drug
E)purine analog chemotherapy drug
F)kinase inhibitor chemotherapy drug
G)chemotherapy antibiotic drug
H)taxane chemotherapy drug
I)chemotherapy protocol
J)pyrimidine analog chemotherapy drug
1)aprepitant (Emend)
2)capecitabine (Xeloda)
3)doxorubicin (Adriamycin)
4)filgrastim (Neupogen)
5)goserelin (Zoladex)
6)imatinib (Gleevec)
7)MACC
8)methotrexate (Trexall)
9)paclitaxel (Onxol)
"10)cladribine (Leustatin)
"

Question 65

Interferon is produced by macrophages that engulfed a hepatitis ________,as well as different types of cancer.

Question 66

The generic drugs vinblastine,vincristine,and vinorelbine all belong to the category of ________ alkaloid chemotherapy drugs.

Question 67

What happened when the drug thalidomide was used to treat morning sickness that almost ended any use of this drug?

Question 68

Describe which types of normal cells in the body are affected by chemotherapy drugs and why they are affected.

Question 69

To determine the type of cancer,a ________ is taken from the tumor site or a blood specimen is drawn to examine blood cells.

Question 70

Topoisomerase is a/an ________ that creates a break in a single strand of DNA to relieve stress during cell division.

Question 71

Give three reasons why chemotherapy drugs cause the side effects of nausea and vomiting.

Question 72

Explain what a chemotherapy protocol is and what advantage it offers over a single chemotherapy drug.

Question 73

What was the original source of taxane chemotherapy drugs,and why did that source change?

Question 74

Adjuvant therapy refers to chemotherapy or ________ therapy given after a patient has had surgery to remove a tumor.

Question 75

Describe how chemotherapy drugs are prepared in a special sterile environment.

Question 76

Describe how the first chemotherapy drug-nitrogen mustard-was discovered and what cancer it was used to treat.

Question 77

Estrogen hormone drugs act in a similar way to the main female hormone ________,which is produced by follicles of the ovary.