Deck 4: Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Question 1

MATCHING
Match the lymphoid organs with the appropriate classification.

Bone marrow

A)Primary
B)Secondary

Answer 1

Primary

Question 2

Match the lymphoid organs with the approximate percentage of T lymphocytes.
Lymph nodes
See Table 4-1,Approximate Percentage of Lymphocytes in Lymphoid Organs.

A)80%
B)60%
C)20%
D)10%

Answer 2

60%

Question 3

The T cell receptor (TCR)recognizes an antigen:

A) when it is coated with antibody.
B) when it is coated with complement.
C) as a peptide bonded to an MHC class II molecule on the surface of an antigen-presenting cell.
D) as a free-floating antigen in the peripheral blood or lymphatic circulation.

Answer 3

as a peptide bonded to an MHC class II molecule on the surface of an antigen-presenting cell.

Question 4

Cluster designation (CD)antigens are involved in various lymphocyte functions,which can include:

A) promotion of cell-to-cell interactions and adhesion.
B) transduction of signals that lead to lymphocyte activation.
C) detection of cytokine secretion.
D) both a and b

Question 5

What is the source of undifferentiated T lymphocytes?

A) Bone marrow
B) Lymph nodes
C) Liver and spleen
D) Thymus

Question 6

Diminished immunoglobulin levels can be related to:

A) a deficit of activated T lymphocytes.
B) impaired phagocytosis.
C) lack of complement production.
D) overproduction of B lymphocytes.

Question 7

Functions of an activated T lymphocyte include:

A) proliferation and differentiation.
B) production of cytokines.
C) development of effector function.
D) all of the above.

Question 8

Mature T lymphocytes survive for ________ compared with B lymphocytes,which survive for a few days.

A) a few hours
B) several months
C) years
D) either b or c

Question 9

When mature T lymphocytes leave the thymus,their T cell receptors are either CD4+ or:

A) CD2+.
B) CD8+.
C) CD19+.
D) CD31+.

Question 10

The CD cell surface membrane marker that appears during the first stage of T lymphocyte development and remains present as an identifying marker to T lymphocytes is:

A) CD2.
B) CD4.
C) CD8.
D) CD10.

Question 11

Match the lymphoid organs with the approximate percentage of T lymphocytes.
Bone marrow
See Table 4-1,Approximate Percentage of Lymphocytes in Lymphoid Organs.

A)80%
B)60%
C)20%
D)10%

Question 12

In antigen recognition by T lymphocytes,each cell:

A) is clonally restricted.
B) expresses a receptor able to react with a given peptide.
C) can only recognize a limited number of antigens.
D) all of the above.

Question 13

Which characteristic is not associated with B lymphocytes?

A) Demonstrate surface immunoglobulin (sIg)
B) Differentiate into plasma cells with antigenic stimulation
C) Participate in an anamnestic response as memory cells
D) Can directly lyse a foreign antigen

Question 14

Match the T cell populations with the appropriate description.
Helper T type 2 (Th2)

A)Play a greater role in the regulation of antibody production and the release of cytokines required for B cell differentiation
B)Responsible for cell-mediated effector mechanisms
C)An immunoregulatory type of Th cells

Question 15

If an immune dysfunction is suspected in a child,the appropriate workup would be a(n):

A) complete blood count.
B) lymphocyte profile by flow cytometry.
C) immunoglobulin electrophoresis.
D) all of the above.

Question 16

Match the T cell populations with the appropriate description.
Helper T type 1 (Th1)

A)Play a greater role in the regulation of antibody production and the release of cytokines required for B cell differentiation
B)Responsible for cell-mediated effector mechanisms
C)An immunoregulatory type of Th cells

Question 17

MATCHING
Match the lymphoid organs with the appropriate classification.

Lymph nodes

A)Primary
B)Secondary

Question 18

A cell-mediated immunodeficiency is suggested if the child has:

A) recurrent bacterial infections.
B) recurrent fungal infections.
C) allergic reactions to drugs and soaps.
D) both a and b

Question 19

Surface markers on lymphocytes can be used to:

A) identify and count CD4+ and CD8+ cells.
B) classify leukemic cells.
C) monitor patients on immunotherapy.
D) all of the above.

Question 20

Match the lymphoid organs with the approximate percentage of T lymphocytes.
Blood
See Table 4-1,Approximate Percentage of Lymphocytes in Lymphoid Organs.

A)80%
B)60%
C)20%
D)10%

Question 21

Match the lymphocyte types with the appropriate characteristic.

Cytotoxic T lymphocytes,or T cytotoxic (Tc)cells

A)Effector cells that can directly destroy virally infected target cells
B)Downregulate the actions of other T and B cells
C)Relatively high avidity for self-antigens

Question 22

Match the lymphocyte types with the appropriate description.

K-type lymphocytes

A)Lead to antibody production
B)Destroy target cells through an extracellular nonphagocytic mechanism (cytotoxic reaction)
C)Kill target cells sensitized with antibody

Question 23

Match the lymphocyte types with the appropriate characteristic.

Natural Treg cells

A)Effector cells that can directly destroy virally infected target cells
B)Downregulate the actions of other T and B cells
C)Relatively high avidity for self-antigens

Question 24

Match the disorders with the appropriate description.(Use each answer only once. )

Bruton's disorder

A)Inadequate response to Epstein-Barr virus
B)T cell defect
C)Likely to be confused with pediatric AIDS
D)Low levels of antibodies
E)Poor humoral response to bacterial polysaccharide antigens

Question 25

Match the disorders with the appropriate description.(Use each answer only once. )

DiGeorge syndrome

A)Inadequate response to Epstein-Barr virus
B)T cell defect
C)Likely to be confused with pediatric AIDS
D)Low levels of antibodies
E)Poor humoral response to bacterial polysaccharide antigens

Question 26

Match the lymphocyte types with the appropriate characteristic.

Suppressor T lymphocytes or T suppressor (Ts)cells

A)Effector cells that can directly destroy virally infected target cells
B)Downregulate the actions of other T and B cells
C)Relatively high avidity for self-antigens

Question 27

Match the lymphocyte types with the appropriate description.

B lymphocytes

A)Lead to antibody production
B)Destroy target cells through an extracellular nonphagocytic mechanism (cytotoxic reaction)
C)Kill target cells sensitized with antibody

Question 28

Match the disorders with the appropriate description.(Use each answer only once. )

Duncan's disease

A)Inadequate response to Epstein-Barr virus
B)T cell defect
C)Likely to be confused with pediatric AIDS
D)Low levels of antibodies
E)Poor humoral response to bacterial polysaccharide antigens

Question 29

Match the disorders with the appropriate description.(Use each answer only once. )

Wiskott-Aldrich syndrome

A)Inadequate response to Epstein-Barr virus
B)T cell defect
C)Likely to be confused with pediatric AIDS
D)Low levels of antibodies
E)Poor humoral response to bacterial polysaccharide antigens

Question 30

Match the disorders with the appropriate description.(Use each answer only once. )

Nezelof syndrome

A)Inadequate response to Epstein-Barr virus
B)T cell defect
C)Likely to be confused with pediatric AIDS
D)Low levels of antibodies
E)Poor humoral response to bacterial polysaccharide antigens

Question 31

Match the T cell populations with the appropriate description.
Regulatory T (Treg)

A)Play a greater role in the regulation of antibody production and the release of cytokines required for B cell differentiation
B)Responsible for cell-mediated effector mechanisms
C)An immunoregulatory type of Th cells

Question 32

Match the lymphocyte types with the appropriate description.

Natural killer cells

A)Lead to antibody production
B)Destroy target cells through an extracellular nonphagocytic mechanism (cytotoxic reaction)
C)Kill target cells sensitized with antibody