Deck 22: Infectious Mononucleosis

Question 1

Immunocompetent individuals maintain EBV as a(n):

A) active infection.
B) chronic latent infection.
C) asymptomatic carrier.
D) symptomatic carrier.

Answer 1

chronic latent infection.

Question 2

Immunoglobulin M (IgM)heterophil antibody is characterized by reaction with horse,ox,and sheep erythrocytes.

Answer 2

True

Question 3

Viral capsid antigen (VCA)is produced by:

A) phagocytic neutrophils.
B) infected T lymphocytes.
C) infected B lymphocytes.
D) both b and c

Answer 3

infected B lymphocytes.

Question 4

In rapid MonoSlide testing,a false-positive result can be caused by:

A) observing agglutination after the observation time.
B) misinterpreting agglutination.
C) residual heterophil antibody present after clinical symptoms have subsided.
D) all of the above.

Question 5

The MonoSlide test is based on the agglutination of:

A) sheep erythrocytes.
B) horse erythrocytes.
C) latex-coated particles.
D) guinea pig antigen.

Question 6

In the adult population,________ of individuals with acute infectious mononucleosis do not produce heterophil antibodies.

A) 5% to 10%
B) 10% to 20%
C) 20% to 50%
D) 50% to 100%

Question 7

IgM type of heterophil antibodies usually appear during the __________ phase of infectious mononucleosis.

A) acute
B) chronic
C) latent
D) carrier

Question 8

Immunoglobulin M (IgM)heterophil antibody is characterized by no reaction with EBV-specific antigens.

Question 9

The use of horse erythrocytes in rapid slide tests for infectious mononucleosis increases the:

A) readability.
B) sensitivity.
C) specificity.
D) all of the above.

Question 10

All the following statements about Epstein-Barr virus (EBV)are true except that it:

A) usually causes an acute,benign condition.
B) usually causes a self-limiting,lymphoproliferative condition.
C) is the cause of Burkitt's lymphoma.
D) is not an agent in the development of nasopharyngeal carcinoma.

Question 11

Immunoglobulin M (IgM)heterophil antibody is characterized by no absorption by beef erythrocytes.

Question 12

In infectious mononucleosis,EBV:

A) infects B lymphocytes.
B) produces lymphocytes in peripheral blood with T cell characteristics.
C) induces a cytotoxic response against the EBV-infected circulating B lymphocytes.
D) all of the above.

Question 13

EBV is transmitted primarily by:

A) close contact with infectious oropharyngeal secretions.
B) blood transfusion.
C) transplacental exposure.
D) transplanted organs or tissues.

Question 14

EBV is typically manifested by:

A) young children.
B) young adults.
C) middle-aged individuals.
D) older adults.

Question 15

A blood transfusion from an immune donor to a nonimmune recipient may produce:

A) no effect.
B) a primary infection.
C) a secondary infection.
D) a reactivated infection.

Question 16

Which of the following stages of infectious mononucleosis infection is characterized by antibody to Epstein-Barr nuclear antigen (EBNA)?

A) Recent (acute)infection
B) Past infection (convalescent)period
C) Reactivation of latent infection
D) Both b and c

Question 17

Epstein-Barr virus (EBV)is:

A) a DNA herpesvirus.
B) harbored by B lymphocytes in latent infections.
C) the most ubiquitous virus known to humans.
D) all of the above.

Question 18

Immunoglobulin M (IgM)heterophil antibody is characterized by absorption by guinea pig kidney cells.

Question 19

Approximately which percentage of young adults demonstrate antibodies to EBV?

A) Less than 10%
B) 25%
C) 50%
D) 100%

Question 20

Anti-VCA immunoglobulin G (IgG)is usually detectable within:

A) 24 hours.
B) 72 hours.
C) 3 to 5 days.
D) 4 to 7 days.

Question 21

MATCHING
Match each procedure to the appropriate description.

Davidsohn differential test

A)Distinguishes between heterophil antibodies;uses beef erythrocytes,guinea pig kidney cells,and sheep erythrocytes
B)Detects heterophil antibodies and uses horse erythrocytes
C)Detects heterophil antibodies and uses sheep erythrocytes

Question 22

MATCHING
Match each procedure to the appropriate description.

Paul-Bunnell screening test

A)Distinguishes between heterophil antibodies;uses beef erythrocytes,guinea pig kidney cells,and sheep erythrocytes
B)Detects heterophil antibodies and uses horse erythrocytes
C)Detects heterophil antibodies and uses sheep erythrocytes

Question 23

MATCHING
Match each procedure to the appropriate description.

MonoSlide agglutination test

A)Distinguishes between heterophil antibodies;uses beef erythrocytes,guinea pig kidney cells,and sheep erythrocytes
B)Detects heterophil antibodies and uses horse erythrocytes
C)Detects heterophil antibodies and uses sheep erythrocytes

Question 24

Fill in the blanks in the table.
1.No previous exposure
A)Viral capsid antigen (VCA)IgG-negative (-)
B)VCA IgG positive (+)
2.Recent (acute)infection
A)VCA IgM-negative (-)
B)VCA IgM-positive (+)
3.Past infection (convalescent)period
A)VCA IgG-negative (-)
B)VCA IgG-positive (+)
4.Reactivation of latent infection

A)VCA IgG-negative (-)
B)VCA IgG positive (+)
Characteristic Antibody Formation in Infectious Mononucleosis

Question 25

Fill in the blanks.The incubation period of infectious mononucleosis is from (1)__________days;once fully developed,it lasts for (2)________ weeks.

A)1 to 2
B)1 to 4
C)2 to 4
D)3 to 6
E)5 to 10
F)10 to 50