Deck 33: Tumor Immunology

Question 1

A new positive prognostic indicator for primary breast cancer in women is:

A) a good gene expression signature.
B) a low S phase tumor cell content.
C) diploid DNA content of tumor cells.
D) all of the above.

Answer 1

a good gene expression signature.

Question 2

The most common cause of pediatric cancer deaths is:

A) acute lymphoblastic leukemia.
B) tumors of the central and sympathetic nervous system.
C) malignant lymphoma.
D) renal tumors.

Answer 2

acute lymphoblastic leukemia.

Question 3

Cancer results from a series of genetic alterations that can include affecting a host's ability to repair resulting damage to DNA.

Answer 3

True

Question 4

The term tumor is commonly used to describe a proliferation of cells that produces a(n):

A) mass.
B) inflammatory condition.
C) reaction.
D) either b or c

Question 5

Tumors are neoplasms.

Question 6

Tumor immunity has the following general feature-tumors express antigens that are recognized as foreign by the immune system of the tumor-bearing host.

Question 7

Cancer results from a series of genetic alterations that can include loss of tumor suppressor gene activity,which inhibits cell growth.

Question 8

Match the antigens with the appropriate description.

Tumor-specific antigens

A)Cell surface molecules coded for by tumorigenic viruses
B)Gene derepression responsible for the production of increased concentrations of these gene products
C)Chemically induced tumors
D)Caused by no known mechanism

Question 9

Cancer results from a series of genetic alterations that can include inactivation of oncogenes that promote cell growth.

Question 10

Tumor immunity has the following general feature-the normal immune response frequently prevents the growth of tumors.

Question 11

MATCHING
Match the characteristics with the type of tumor.

Metastasis

A)Benign
B)Malignant

Question 12

Most tumors are of connective tissue origin.

Question 13

A cancer-disposing gene,BRCA2,is associated with a very high risk of:

A) uterine cancer.
B) endometrial cancer.
C) breast cancer.
D) none of the above.

Question 14

The evaluation of HER2/neu has what clinical function?

A) Diagnostic marker
B) Predictive marker for response to herceptin
C) Prognostic marker in breast cancer
D) Both b and c

Question 15

MATCHING
Match the characteristics with the type of tumor.

Usually encapsulated

A)Benign
B)Malignant

Question 16

Tumors can be described as benign or malignant.

Question 17

MATCHING
Match the characteristics with the type of tumor.

Minimal mitotic activity

A)Benign
B)Malignant

Question 18

MATCHING
Match the characteristics with the type of tumor.

Resembling the parent tissue

A)Benign
B)Malignant

Question 19

MATCHING
Match the characteristics with the type of tumor.

Increase in number of cells that accumulate

A)Benign
B)Malignant

Question 20

Tumor immunity has the following general feature-the immune system can be stimulated to kill tumor cells and rid the host of the tumor.

Question 21

Match the following.Chemotherapeutic agents are placed into various classes of drug action:

Act on the S,G2,or M phase of mitosis

A)Cell cycle active,phase-specific
B)Cell cycle active,phase-nonspecific
C)Non-cell cycle active

Question 22

Match the antigens with the appropriate description.

Spontaneous tumor antigens

A)Cell surface molecules coded for by tumorigenic viruses
B)Gene derepression responsible for the production of increased concentrations of these gene products
C)Chemically induced tumors
D)Caused by no known mechanism

Question 23

Match the antigens with the appropriate description.

Tumor-associated antigens

A)Cell surface molecules coded for by tumorigenic viruses
B)Gene derepression responsible for the production of increased concentrations of these gene products
C)Chemically induced tumors
D)Caused by no known mechanism

Question 24

Match the following.Chemotherapeutic agents are placed into various classes of drug action:

Corticosteroids

A)Cell cycle active,phase-specific
B)Cell cycle active,phase-nonspecific
C)Non-cell cycle active

Question 25

Match the antigens with the appropriate description.

Carcinofetal antigens

A)Cell surface molecules coded for by tumorigenic viruses
B)Gene derepression responsible for the production of increased concentrations of these gene products
C)Chemically induced tumors
D)Caused by no known mechanism