Deck 30: Leukemia

Question 1

Radiation exposure is risk factor for leukemia.

Answer 1

True
The markedly higher incidence of acute leukemia among survivors of the atomic bomb explosions in Japan has suggested that ionizing radiation may play a role in leukemogenesis.

Question 2

What is the treatment of choice for leukemias?

A) surgery
B) chemotherapy
C) radiation therapy
D) bone marrow transplant

Answer 2

D
Bone marrow transplantation,which was considered an experimental procedure until approximately 25 years ago,is the treatment of choice for several diseases,including ALL,AML,and CML.

Question 3

A lower than normal dose rate is used to treat total-body irradiation (TBI).

Answer 3

True
The dose rate has a slight variation depending on the institution-specific formula.Typically,the dose rate is set for an adult at 200 cGy/min and less for the pediatric population.

Question 4

Which type of leukemia accounts for nearly 15% of all adult leukemias and is uncommon before the age of 35?

A) ALL
B) AML
C) CLL
D) CML

Question 5

Children are most likely to develop which type of leukemia?

A) ALL
B) AML
C) CLL
D) CML

Question 6

Which of the following is not true concerning CLL?

A) It can be confused for a lymphoma.
B) Only symptomatic patients are treated.
C) It resembles CML but with a malignant lymphoid cell line.
D) It is a disease of children.

Question 7

Which chemotherapy agent can be used to reduce the leukemic cell load and impair the host's ability to reject the donor bone marrow?

A) dexamethasone
B) vincristine
C) L-asparaginase
D) cyclophosphamide

Question 8

Which of the following is also known as maintenance therapy?

A) remission induction
B) consolidation
C) prophylaxis of overt CNS disease
D) continuation therapy

Question 9

What organ(s)is(are)always shielded during AP/PA TBI treatments?

A) spinal cord
B) larynx
C) lungs
D) all of the above

Question 10

Which FAB stage are most pediatric ALLs?

A) L1
B) L2
C) L3
D) L4

Question 11

Which of the following stages in the natural history of CML is also known as blast crisis?

A) plague
B) chronic
C) accelerated
D) acute

Question 12

Which of the following is not one of the stages in the natural history of CML?

A) plague
B) chronic
C) accelerated
D) acute

Question 13

Which of the following is not a symptom commonly associated with a diagnosis of leukemia?

A) fever
B) loss of appetite
C) dysphagia
D) weight loss

Question 14

CML and CLL occur more frequently in children than in adults.

Question 15

TBI can used as part of the treatment of patients with leukemia.

Question 16

What is the dose/fraction schedule for TBI?

A) 12 Gy,6 fx,bid
B) 13.5 Gy,6 fx,bid
C) 6 Gy,2 fx,bid
D) all of the above

Question 17

Which of the following cells is not considered part of hematopoiesis?

A) neutrophils
B) basophils
C) platelets
D) neurons

Question 18

What is the most common type of pediatric leukemia?

A) ALL
B) AML
C) CLL
D) CML

Question 19

Leukemia is the most common pediatric cancer.

Question 20

Patients needing TBI can be treated with either an AP/PA or opposed lateral treatment arrangement.