Deck 34: Central Nervous System Tumors

Question 1

What grade are GBMs?
I)I/I
II)II/II
II)III/III
IV)IV/IV

A) I only
B) IV only
C) I and II
D) III and IV

Answer 1

D
Most pathology reports will indicate how many grades have been used to describe the tumor.For example,grade II/IV represents grade 2 in the 4-grade system; grade II/III represents grade 2 using a 3-grade system.Glioblastoma multiforme represents the highest grade of both the 3- and 4-grade systems.

Question 2

Metastatic brain lesions are more common in children than are primary brain tumors.

Answer 2

False
Medulloblastomas are the most common malignant nervous system tumors of childhood.

Question 3

Which of the following factors can limit the usefulness of surgery for CNS neoplasms?

A) tumor location and extent
B) patient status
C) risk of causing neurologic damage
D) all of the above

Answer 3

D
Surgery can be limited by the tumor location and extent,patient status,and risk of causing debilitating neurologic deficits.

Question 4

The entire brain is irradiated when treating a primary brain tumor.

Question 5

Primary brain tumors rarely metastasize.

Question 6

What is the standard dose delivered to the tumor of a patient with high grade astrocytomas?

A) 3000 to 3500 cGy
B) 4000 to 4500 cGy
C) 5000 to 5500 cGy
D) 6000 to 6500 cGy

Question 7

Radiation necrosis of brain tissue occurs with doses higher than 6000 cGy.

Question 8

What is the most common source of brain metastases?

A) colon
B) lung
C) breast
D) melanoma

Question 9

In which portion of the CNS do most CNS tumors occur?

A) cerebrum
B) cerebellum
C) brain stem
D) thalamus

Question 10

From which cells to medulloblastomas arise?

A) primitive neuroectodermal tumor (PNET)
B) primitive neuroectodermal cells
C) astrocytes
D) lymphocytes

Question 11

What is the standard dose delivered to the tumor of a patient with a low grade astrocytoma?

A) 3000 to 3500 cGy
B) 4000 to 4500 cGy
C) 5000 to 5500 cGy
D) 6000 to 6500 cGy

Question 12

What is the current 5-year survival of patients with giolblastoma multiforme (GBM)?

A) 35%
B) 55%
C) 75%
D) 95%

Question 13

What is the most common type of brain tumor?

A) GBM
B) astrocytoma
C) meninegioma
D) metastatic brain lesions

Question 14

T2 lesions are the most common stage of primary brain tumors.

Question 15

Primary brain lesions are the leading cause of cancer-related deaths in children.

Question 16

Which of the following conditions is a contraindication for stereotactic radiosurgery (SRS)?

A) spherical tumor
B) 2-cm tumor
C) brain metastases
D) five lesions

Question 17

Which tumors spread through the cerebral spinal fluid?

A) astrocytoma
B) oligodendroglioma
C) medulloblastoma
D) schwannoma

Question 18

Which portion of the brain is the site of intelligence and judgment?

A) cerebrum
B) cerebellum
C) brain stem
D) thalamus

Question 19

What is the most common CNS tumor in children?

A) medulloblastoma
B) metastatic lesion
C) astrocytoma
D) craniopharyngioma

Question 20

Which of the following cells is responsible for myelin production?

A) neurons
B) Schwann cells
C) astrocytes
D) ependymal cells

Question 21

What is the 5-year survival rate for all CNS tumors combined?

A) 20%
B) 35%
C) 50%
D) 75%

Question 22

What is the most common grade of gliomas?

A) low grade
B) intermediate grade
C) high grade
D) mixed grade

Question 23

Which of the following is most significant to the prognosis of brain tumors?

A) tumor size
B) lymph node involvement
C) metastases
D) grade

Question 24

Which of the following is a late effect of brain irradiation in children?

A) leukemia
B) decreased IQ
C) gigantism
D) chronic fatigue

Question 25

What defines the inferior radiation field border for the treatment of the whole brain for palliation?

A) 1-cm flash
B) superior orbital ridge
C) external auditory meatus
D) b and c