Deck 21: Miscellaneous Bacterial Agents of Disease
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ملء الشاشة (f)
Deck 21: Miscellaneous Bacterial Agents of Disease
1
Which of the following is not transmitted via an arthropod vector?
A)Leptospirosis
B)Lyme disease
C)Rocky Mountain spotted fever
D)Epidemic typhus
E)Human Ehrlichosis
A)Leptospirosis
B)Lyme disease
C)Rocky Mountain spotted fever
D)Epidemic typhus
E)Human Ehrlichosis
A
2
Treponema, Borrelia, and Leptospira are all
A)obligate parasites requiring host cells.
B)curved rods.
C)transmitted by arthropod vectors.
D)spirochetes.
E)bacteria without cell walls.
A)obligate parasites requiring host cells.
B)curved rods.
C)transmitted by arthropod vectors.
D)spirochetes.
E)bacteria without cell walls.
D
3
Control of rodent populations is important for preventing
A)tick-borne relapsing fever.
B)ornithosis.
C)epidemic typhus.
D)Q fever.
E)All of the choices are correct.
A)tick-borne relapsing fever.
B)ornithosis.
C)epidemic typhus.
D)Q fever.
E)All of the choices are correct.
A
4
Lyme disease involves
A)early symptoms of fever, headache, stiff neck.
B)crippling polyarthritis and cardiovascular and neurological problems.
C)people having contact with wooded or forested areas.
D)treatment with antimicrobics.
E)All of the choices are correct.
A)early symptoms of fever, headache, stiff neck.
B)crippling polyarthritis and cardiovascular and neurological problems.
C)people having contact with wooded or forested areas.
D)treatment with antimicrobics.
E)All of the choices are correct.
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5
The virulence of Vibrio cholerae is due to its
A)capsule.
B)neurotoxin.
C)invasive enzymes.
D)enterotoxin.
E)All of the above.
A)capsule.
B)neurotoxin.
C)invasive enzymes.
D)enterotoxin.
E)All of the above.
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6
Treponema pallidum subspecies pallidum
A)has humans as the reservoir.
B)can cross the placenta.
C)is the cause of syphilis.
D)is transmitted by direct sexual contact.
E)All of the choices are correct.
A)has humans as the reservoir.
B)can cross the placenta.
C)is the cause of syphilis.
D)is transmitted by direct sexual contact.
E)All of the choices are correct.
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7
The Argyll-Robertson pupil that is fixed and small, and does not react to light but does accommodate for focusing is associated with
A)Lyme disease.
B)leptospirosis.
C)chlamydiosis.
D)Rocky Mountain spotted fever.
E)tertiary syphilis.
A)Lyme disease.
B)leptospirosis.
C)chlamydiosis.
D)Rocky Mountain spotted fever.
E)tertiary syphilis.
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8
Leptospirosis has all the following characteristics except:
A)most common in cattle, horses, pigs, and dogs
B)pathogen is a spirochete
C)infects kidneys, liver, brain, eyes
D)humans acquire it by contact with abraded skin or mucous membranes
E)can be transmitted by animal bites
A)most common in cattle, horses, pigs, and dogs
B)pathogen is a spirochete
C)infects kidneys, liver, brain, eyes
D)humans acquire it by contact with abraded skin or mucous membranes
E)can be transmitted by animal bites
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9
Relapsing fever involves
A)soft-bodied ticks transmitting Borrelia hermsii.
B)initial symptoms of fever, headache, fatigue.
C)campers and forestry personnel.
D)human body louse transmitting Borrelia recurrentis.
E)All of the choices are correct.
A)soft-bodied ticks transmitting Borrelia hermsii.
B)initial symptoms of fever, headache, fatigue.
C)campers and forestry personnel.
D)human body louse transmitting Borrelia recurrentis.
E)All of the choices are correct.
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10
Yaws, Pinta, and Bejel are all diseases that
A)are slow, progressive skin diseases that can spread to deep tissues.
B)are sexually transmitted.
C)are caused by arthropod vectors.
D)are caused by Vibrio species.
E)are respiratory tract infections.
A)are slow, progressive skin diseases that can spread to deep tissues.
B)are sexually transmitted.
C)are caused by arthropod vectors.
D)are caused by Vibrio species.
E)are respiratory tract infections.
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11
The secondary stage of syphilis
A)is when the patient is no longer infectious to others.
B)occurs within 10 days of the primary stage.
C)is a time when the pathogen enters and multiplies in the blood.
D)has no symptoms.
E)is when gummas develop in tissues.
A)is when the patient is no longer infectious to others.
B)occurs within 10 days of the primary stage.
C)is a time when the pathogen enters and multiplies in the blood.
D)has no symptoms.
E)is when gummas develop in tissues.
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12
The white-footed mouse, deer, and deer ticks are important to maintaining the transmission cycle associated with
A)Lyme disease.
B)leptospirosis.
C)chlamydiosis.
D)Rocky Mountain spotted fever.
E)tertiary syphilis.
A)Lyme disease.
B)leptospirosis.
C)chlamydiosis.
D)Rocky Mountain spotted fever.
E)tertiary syphilis.
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13
Erythema migrans, a bull's-eye rash, at the portal of entry is associated with
A)syphilis.
B)Rocky Mountain spotted fever.
C)relapsing fever.
D)Lyme disease.
E)leptospirosis.
A)syphilis.
B)Rocky Mountain spotted fever.
C)relapsing fever.
D)Lyme disease.
E)leptospirosis.
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14
The chancre of syphilis
A)occurs due to small hemorrhaging of capillaries.
B)is very painful.
C)occurs during the tertiary stage.
D)develops into a lesion with firm margins and an ulcerated central crater.
E)All of the choices are correct.
A)occurs due to small hemorrhaging of capillaries.
B)is very painful.
C)occurs during the tertiary stage.
D)develops into a lesion with firm margins and an ulcerated central crater.
E)All of the choices are correct.
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15
The causative agent of Lyme disease is
A)Ixodes scapularis.
B)Borrelia hermsii.
C)Borrelia burgdorferi.
D)Ixodes pacificus.
E)Leptospira interrogans.
A)Ixodes scapularis.
B)Borrelia hermsii.
C)Borrelia burgdorferi.
D)Ixodes pacificus.
E)Leptospira interrogans.
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16
During which stage of syphilis does fever, lymphadenopathy, and a red to brown rash occur?
A)Primary
B)Secondary
C)Tertiary
D)Latent
E)All of the choices are correct
A)Primary
B)Secondary
C)Tertiary
D)Latent
E)All of the choices are correct
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17
Permanent cardiovascular and neurological damage is seen in which stage of syphilis?
A)Primary
B)Secondary
C)Tertiary
D)Latent
E)All of the choices are correct.
A)Primary
B)Secondary
C)Tertiary
D)Latent
E)All of the choices are correct.
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18
Which is not a characteristic of spirochetes?
A)All are pathogenic
B)Gram negative
C)Helical shape
D)Always motile
E)Endoflagella enclosed in periplasmic space
A)All are pathogenic
B)Gram negative
C)Helical shape
D)Always motile
E)Endoflagella enclosed in periplasmic space
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19
The RPR, VDRL, MHA-TP, FTA-ABS, and TPI tests are used to diagnose
A)chlamydiosis.
B)syphilis.
C)lyme disease.
D)Rocky Mountain spotted fever.
E)Q fever.
A)chlamydiosis.
B)syphilis.
C)lyme disease.
D)Rocky Mountain spotted fever.
E)Q fever.
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20
Infected animals shed Leptospira interrogans in their
A)feces.
B)blood.
C)urine.
D)respiratory secretions.
E)saliva.
A)feces.
B)blood.
C)urine.
D)respiratory secretions.
E)saliva.
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21
Which is mismatched?
A)Epidemic typhus - body louse feces
B)Murine typhus - flea feces
C)Rickettsial pox - mite bite
D)Rocky Mountain spotted fever - tick bite
E)Human ehrlichiosis - flea bite
A)Epidemic typhus - body louse feces
B)Murine typhus - flea feces
C)Rickettsial pox - mite bite
D)Rocky Mountain spotted fever - tick bite
E)Human ehrlichiosis - flea bite
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22
Ornithosis
A)is caused by Chlamydia pneumoniae.
B)is a zoonosis of certain types of birds.
C)is a mild, upper respiratory tract illness.
D)has humans as a reservoir for the pathogen.
E)All of the choices are correct.
A)is caused by Chlamydia pneumoniae.
B)is a zoonosis of certain types of birds.
C)is a mild, upper respiratory tract illness.
D)has humans as a reservoir for the pathogen.
E)All of the choices are correct.
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23
Oral flora bacteria on the tooth surface
A)develop a biofilm.
B)use fimbriae and slime layers to adhere.
C)include streptococci that metabolize sucrose, produce sticky glucans, and form plaque.
D)lactobacilli and streptococci ferment carbohydrates and produce acids that cause caries.
E)All of the choices are correct.
A)develop a biofilm.
B)use fimbriae and slime layers to adhere.
C)include streptococci that metabolize sucrose, produce sticky glucans, and form plaque.
D)lactobacilli and streptococci ferment carbohydrates and produce acids that cause caries.
E)All of the choices are correct.
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24
The most immediate and important treatment needed to prevent death in cholera victims is
A)water and electrolyte replacement.
B)antimicrobics.
C)antitoxin.
D)surgery.
E)None of the choices are correct.
A)water and electrolyte replacement.
B)antimicrobics.
C)antitoxin.
D)surgery.
E)None of the choices are correct.
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25
Characteristics of rickettsias include
A)obligate parasites requiring host cells for growth.
B)arthropods serve as life cycle hosts and vectors.
C)gram negative coccobacilli.
D)host cells are required for ATP metabolism.
E)All of the choices are correct.
A)obligate parasites requiring host cells for growth.
B)arthropods serve as life cycle hosts and vectors.
C)gram negative coccobacilli.
D)host cells are required for ATP metabolism.
E)All of the choices are correct.
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26
Rocky Mountain spotted fever
A)is seen in highest numbers along the west coast.
B)is transmitted by Ixodes ticks.
C)has symptoms that include fever, headache, and rash.
D)never has severe complications.
E)All of the choices are correct.
A)is seen in highest numbers along the west coast.
B)is transmitted by Ixodes ticks.
C)has symptoms that include fever, headache, and rash.
D)never has severe complications.
E)All of the choices are correct.
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27
Chlamydia trachomatis causes
A)nongonococcal urethritis (NGU) in males.
B)cervicitis in females.
C)congenital and adult inclusion conjunctivitis.
D)ocular trachoma.
E)All of the choices are correct.
A)nongonococcal urethritis (NGU) in males.
B)cervicitis in females.
C)congenital and adult inclusion conjunctivitis.
D)ocular trachoma.
E)All of the choices are correct.
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28
All of the following are characteristics of Campylobacter jejuni except
A)it is transmitted through ingestion of contaminated chicken, meat, milk, and water.
B)it causes fever and a watery to bloody diarrhea.
C)it infects the stomach.
D)it produces an enterotoxin called CJT that stimulates diarrhea.
E)it has gram negative curved rods with darting motility.
A)it is transmitted through ingestion of contaminated chicken, meat, milk, and water.
B)it causes fever and a watery to bloody diarrhea.
C)it infects the stomach.
D)it produces an enterotoxin called CJT that stimulates diarrhea.
E)it has gram negative curved rods with darting motility.
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29
All of the following are correct about primary atypical pneumonia except
A)it is mainly caused by Mycoplasma pneumoniae.
B)it can also be caused by adenoviruses.
C)it is transmitted by aerosol droplets.
D)it has symptoms similar to pneumococcal pneumonia.
E)community resistance is high.
A)it is mainly caused by Mycoplasma pneumoniae.
B)it can also be caused by adenoviruses.
C)it is transmitted by aerosol droplets.
D)it has symptoms similar to pneumococcal pneumonia.
E)community resistance is high.
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30
Which is incorrect regarding Q fever?
A)Transmitted by lice
B)Pathogen produces resistant spores
C)Humans infected from unpasteurized milk and airborne spread
D)Causes fever, muscle aches, rash, and sometimes pneumonia
E)Is a zoonosis
A)Transmitted by lice
B)Pathogen produces resistant spores
C)Humans infected from unpasteurized milk and airborne spread
D)Causes fever, muscle aches, rash, and sometimes pneumonia
E)Is a zoonosis
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31
An organism found in coastal waters that causes a food infection and gastroenteritis due to a variety of contaminated raw and undercooked seafood is
A)Chlamydia trachomatis.
B)Vibrio parahaemolyticus.
C)Vibrio cholerae.
D)Campylobacter jejuni.
E)Helicobacter pylori.
A)Chlamydia trachomatis.
B)Vibrio parahaemolyticus.
C)Vibrio cholerae.
D)Campylobacter jejuni.
E)Helicobacter pylori.
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32
"Rice water stools" are associated with disease caused by this organism:
A)Vibrio vulnificus
B)Vibrio parahaemolyticus
C)Vibrio cholerae
D)Campylobacter jejuni
E)Helicobacter pylori
A)Vibrio vulnificus
B)Vibrio parahaemolyticus
C)Vibrio cholerae
D)Campylobacter jejuni
E)Helicobacter pylori
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33
Which is mismatched?
A)Rickettsia rickettsii - epidemic typhus
B)Coxiella burnetii - Q fever
C)Bartonella quintana - trench fever
D)Bartonella henselae - cat scratch disease
E)Rickettsia typhi - endemic (murine) typhus
A)Rickettsia rickettsii - epidemic typhus
B)Coxiella burnetii - Q fever
C)Bartonella quintana - trench fever
D)Bartonella henselae - cat scratch disease
E)Rickettsia typhi - endemic (murine) typhus
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34
Helicobacter pylori causes
A)gastritis.
B)duodenal ulcers.
C)stomach ulcers.
D)increased risk for stomach cancer.
E)All of the choices are correct.
A)gastritis.
B)duodenal ulcers.
C)stomach ulcers.
D)increased risk for stomach cancer.
E)All of the choices are correct.
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35
Which is not a characteristic of Helicobacter pylori?
A)gram negative
B)produces enteroxin that causes diarrhea
C)curved rods
D)lives in the stomach
E)produces urease that buffers stomach acidity
A)gram negative
B)produces enteroxin that causes diarrhea
C)curved rods
D)lives in the stomach
E)produces urease that buffers stomach acidity
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36
The pathogenesis of rickettsial infections often involves infection of
A)endothelial lining of blood vessels.
B)gastrointestinal lining.
C)dermis of the skin.
D)stomach mucosa.
E)urinary tract.
A)endothelial lining of blood vessels.
B)gastrointestinal lining.
C)dermis of the skin.
D)stomach mucosa.
E)urinary tract.
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37
The following are characteristics of Chlamydias except:
A)gram negative
B)obligate parasites that need host cells for growth
C)elementary bodies are the infectious form
D)elementary bodies lack enzyme systems for making ATP
E)reticulate bodies differentiate into elementary bodies
A)gram negative
B)obligate parasites that need host cells for growth
C)elementary bodies are the infectious form
D)elementary bodies lack enzyme systems for making ATP
E)reticulate bodies differentiate into elementary bodies
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38
Which is incorrect about Mycoplasma pneumoniae?
A)Birds are a reservoir.
B)It is a common cause of primary atypical pneumonia.
C)Initially causes fever, malaise, sore throat, headache.
D)After 2 to 3 weeks, it develops into an unproductive cough and earache.
E)Is a bacterial cell without a cell wall.
A)Birds are a reservoir.
B)It is a common cause of primary atypical pneumonia.
C)Initially causes fever, malaise, sore throat, headache.
D)After 2 to 3 weeks, it develops into an unproductive cough and earache.
E)Is a bacterial cell without a cell wall.
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39
Cholera symptoms are
A)copious watery diarrhea.
B)loss of blood volume.
C)acidosis, sunken eyes, thirst.
D)hypotension, tachycardia, shock.
E)All of the choices are correct.
A)copious watery diarrhea.
B)loss of blood volume.
C)acidosis, sunken eyes, thirst.
D)hypotension, tachycardia, shock.
E)All of the choices are correct.
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40
In patients with diabetes or liver disease, ingestion of raw oysters contaminated with this organism can lead to death:
A)Vibrio vulnificus
B)Vibrio parahaemolyticus
C)Vibrio cholerae
D)Campylobacter jejuni
E)Helicobacter pylori
A)Vibrio vulnificus
B)Vibrio parahaemolyticus
C)Vibrio cholerae
D)Campylobacter jejuni
E)Helicobacter pylori
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41
Which of the following diseases could be prevented with proper sewage disposal and water purification?
A)Vibrio parahaemolyticus gastroenteritis
B)Vibrio vulnificus gastroenteritis
C)Cholera
D)Lyme disease
E)Leptospirosis
A)Vibrio parahaemolyticus gastroenteritis
B)Vibrio vulnificus gastroenteritis
C)Cholera
D)Lyme disease
E)Leptospirosis
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42
Which is incorrect about Leptospirosis?
A)It can be avoided by not swimming in livestock watering ponds.
B)A vaccine is not available.
C)Its principle targets are the kidneys, liver, brain, and eyes.
D)It is a zoonosis.
E)Weil's syndrome occurs during the second phase of the disease.
A)It can be avoided by not swimming in livestock watering ponds.
B)A vaccine is not available.
C)Its principle targets are the kidneys, liver, brain, and eyes.
D)It is a zoonosis.
E)Weil's syndrome occurs during the second phase of the disease.
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43
Hutchinson's teeth are
A)a symptom of untreated Lyme disease.
B)a symptom of untreated periodontal disease.
C)a symptom of ANUG.
D)a symptom of congenital syphilis.
E)a symptom of congenital Chlamydia trachomatis.
A)a symptom of untreated Lyme disease.
B)a symptom of untreated periodontal disease.
C)a symptom of ANUG.
D)a symptom of congenital syphilis.
E)a symptom of congenital Chlamydia trachomatis.
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44
Which of the following distinguishes syphilis from yaws?
A)Syphilis is caused by a spirochete.
B)Syphilis has a primary, secondary, and tertiary stages.
C)Syphilis is sexually transmitted.
D)Syphilis is treated with antibiotics.
E)Syphilis is a slow and progressive disease.
A)Syphilis is caused by a spirochete.
B)Syphilis has a primary, secondary, and tertiary stages.
C)Syphilis is sexually transmitted.
D)Syphilis is treated with antibiotics.
E)Syphilis is a slow and progressive disease.
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45
Treponema vincentii, Bacteroides forsythus, and fusobacteria synergistically are involved in which infection?
A)gingivitis
B)necrotizing ulcerative gingivitis (NUG)
C)ornithosis
D)yaws
E)nongonococcal urethritis
A)gingivitis
B)necrotizing ulcerative gingivitis (NUG)
C)ornithosis
D)yaws
E)nongonococcal urethritis
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46
The highest numbers of cases of Rocky Mountain spotted fever occur along the eastern seaboard.
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47
The spirochete of relapsing fever changes cell surface antigens many times in order to avoid destruction by the immune response.
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48
Gingivitis is
A)primarily caused by anaerobic oral flora.
B)erosion of tooth enamel causing a lesion.
C)caused by Streptococcus mutans.
D)also called NUG.
E)None of the choices are correct.
A)primarily caused by anaerobic oral flora.
B)erosion of tooth enamel causing a lesion.
C)caused by Streptococcus mutans.
D)also called NUG.
E)None of the choices are correct.
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49
Which is incorrect about Lyme disease?
A)It is a new disease that started in Lyme, Connecticut.
B)Its reservoirs are mice and deer.
C)It is transmitted by ticks.
D)It is nonfatal.
E)It can slowly progress and mimic rheumatoid conditions.
A)It is a new disease that started in Lyme, Connecticut.
B)Its reservoirs are mice and deer.
C)It is transmitted by ticks.
D)It is nonfatal.
E)It can slowly progress and mimic rheumatoid conditions.
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50
All of the following can positively influence the structure of tooth enamel except
A)fluoride.
B)lysozyme in saliva.
C)antibodies in saliva.
D)refined sugar.
E)genetics.
A)fluoride.
B)lysozyme in saliva.
C)antibodies in saliva.
D)refined sugar.
E)genetics.
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51
Chlamydias and rickettsias are unusual bacteria because they do not have cell walls.
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52
Ureaplasma urealyticum is implicated in which of the following?
A)nongonococcal urethritis
B)Rocky Mountain Spotted Fever
C)periodontal disease
D)Q fever
E)endemic typhus
A)nongonococcal urethritis
B)Rocky Mountain Spotted Fever
C)periodontal disease
D)Q fever
E)endemic typhus
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53
Chlamydia trachomatis is commonly transmitted by direct sexual activity.
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54
NGU is a syndrome among males with chlamydial infections of the urethra.
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55
Lyme disease is only seen in people living in Lyme, Connecticut.
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56
Chlamydiosis can lead to endometritis, salpingitis, and pelvic inflammatory disease.
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57
In severe cases of Rocky Mountain spotted fever, the enlarged lesions of the rash can become necrotic and predispose the patient to gangrene of toes and fingertips.
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58
The tertiary stage of syphilis
A)is when gummas develop in tissues.
B)is when the patient is highly infectious to others.
C)occurs within 10 days of the primary stage.
D)has no symptoms.
E)is when a chancre develops.
A)is when gummas develop in tissues.
B)is when the patient is highly infectious to others.
C)occurs within 10 days of the primary stage.
D)has no symptoms.
E)is when a chancre develops.
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59
Humans are the reservoir for Borrelia hermsii.
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60
Dental caries is the most common human disease.
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61
Discuss the role of Ixodes scapularis and Ixodes pacificus in Lyme disease.
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62
Syphilitic tumors called _____ develop in the liver, skin, bone, and cartilage during the tertiary stage of syphilis.
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63
The two bacterial genera of obligate parasites are _____ and _____.
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64
Mycoplasma and Ureaplasma differ from other bacteria because they naturally lack a _____.
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65
Lyme disease is caused by __transmitted by ticks.
A)Proteus vulgaris
B)Rickettsia typhi
C)Rickettsia rickettsii
D)Borrelia burghdorferi
E)Leptospira interrogans
A)Proteus vulgaris
B)Rickettsia typhi
C)Rickettsia rickettsii
D)Borrelia burghdorferi
E)Leptospira interrogans
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66
Bacteria that lose their cell walls due to penicillin or lysozyme and result in persistent wall-deficient bacteria are called _____.
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67
Discuss the specific, distinguishing features that are the underlying reason for referring to the respiratory infection caused by Mycoplasma pneumoniae as an atypical pneumonia or walking pneumonia.
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68
A patient has a serious lung infection.A sputum sample was taken.The lab technician stated that the lab isolated a bacterium that did not have any peptidoglycan.You hypothesize that the identity of this microbe could possibly be __.
A)Mycobacterium tuberculosis
B)Borrelia burgdorferi
C)Streptococcus pneumoniae
D)Mycoplasma pneumoniae
E)Haemophilus influenzae
A)Mycobacterium tuberculosis
B)Borrelia burgdorferi
C)Streptococcus pneumoniae
D)Mycoplasma pneumoniae
E)Haemophilus influenzae
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69
Which of the following characteristics is NOT true of Treponema pallidum?
A)Requires mammalian host
B)Microaerophilic
C)Causative agent of syphilis
D)Solely utilizes glycolysis for energy
E)Grows well on chocolate agar in the laboratory
A)Requires mammalian host
B)Microaerophilic
C)Causative agent of syphilis
D)Solely utilizes glycolysis for energy
E)Grows well on chocolate agar in the laboratory
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70
Discuss the activities or professions that would increase the risk of contracting Coxiella burnetii.
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71
After being bitten by a tick on a hiking trip, Amy had chills, headache, muscle pain, nausea, lethargy, and rash.Before further testing, Amy's healthcare provider gave her information about which of the following diseases?
A)Anaplasma phagocytophilum and human granulocytic anaplasmosis
B)Ehrlichia chaffeensis and human monocytic ehrlichiosis
C)Shigella and dysentery
D)Streptococcus pyogenes and strep throat
E)Both A & B
A)Anaplasma phagocytophilum and human granulocytic anaplasmosis
B)Ehrlichia chaffeensis and human monocytic ehrlichiosis
C)Shigella and dysentery
D)Streptococcus pyogenes and strep throat
E)Both A & B
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72
According to CDC data, who is more likely to acquire a rickettsial disease?
A)Tom who traveled to Arizona for the summer
B)Sally who went to the beach at Big Sur, CA
C)Mike who visited his aunt in Sub-Saharan Africa
D)Phil who stayed home and mowed his lawn
E)Harry who works in a pet store and hates fleas and ticks
A)Tom who traveled to Arizona for the summer
B)Sally who went to the beach at Big Sur, CA
C)Mike who visited his aunt in Sub-Saharan Africa
D)Phil who stayed home and mowed his lawn
E)Harry who works in a pet store and hates fleas and ticks
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73
Select two diseases that involve different arthropod vectors in their epidemiology.Discuss each disease and describe the role of each vector in the life cycle of the pathogen and establishment of the disease.
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74
When plaque becomes mineralized with calcium and phosphate crystals, it becomes a hard, porous substance called _____.
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