Deck 9: Skeletal Muscle Relaxants

Question 1

A patient with breathing problems has been given a muscle relaxant and begins to experience bronchospasms,which may lead to an asthmatic attack.This can be attributed to the release of:

A) Acetylcholine
B) Norepinephrine
C) Serotonin
D) Histamine

Answer 1

Histamine

Question 2

Dantrolene relaxes muscle by inhibiting the release of which ion from the sarcoplasmic reticulum?

A) Sodium
B) Chloride
C) Potassium
D) Calcium

Answer 2

Calcium

Question 3

A medication that results in spinal hyperpolarization would belong to which class of skeletal muscle relaxants?

A) Nondepolarizing
B) Depolarizing
C) Centrally acting
D) Direct acting

Answer 3

Centrally acting

Question 4

Which medication can potentiate the effects of succinylcholine due to shifting the levels of potassium in the body?

A) Narcotics
B) NSAIDs
C) Antiemetics
D) Diuretics

Question 5

One way to overcome the effects of a rapidly metabolized skeletal muscle relaxant is to administer the medication by:

A) IV injection
B) IV infusion
C) IM injection
D) Subcutaneous injection

Question 6

Tranquilizers activate GABA receptors by causing ___ ions to move ___ the cell.

A) Potassium, outside
B) Sodium, inside
C) Chloride, outside
D) Chloride, inside

Question 7

Which type of skeletal muscle relaxant can be considered a cholinergic receptor antagonist?

A) Nondepolarizing
B) Depolarizing
C) Direct acting
D) Indirect acting

Question 8

Some patients may have a genetic predisposition to developing malignant hyperthermia when taking an inhalation anesthetic with which type of skeletal muscle relaxant?

A) Pancuronium
B) Succinylcholine
C) Dantrolene
D) Baclofen

Question 9

Prolonged use of which centrally acting skeletal muscle relaxant can lead to dependency?

A) Baclofen
B) Methocarbamol
C) Diazepam
D) Orphenadrine

Question 10

What is the drug of choice for treating malignant hyperthermia?

A) Tizanidine
B) Dantrolene
C) Baclofen
D) Diazepam

Question 11

Which of the following should be taken into consideration when selecting a neuromuscular blocking drug for surgical relaxation?

A) Duration of action
B) Time of onset
C) Reversibility
D) All of these are correct.

Question 12

A patient with a spinal cord injury would be treated best with which muscle relaxant?

A) Succinylcholine
B) Dantrolene
C) Baclofen
D) Mevacurium

Question 13

What category of muscle relaxants would be ideal for a patient needing intubation?

A) Depolarizing
B) Nondepolarizing
C) Direct acting
D) Centrally acting

Question 14

Which of the following would be observed from a low dose of a nondepolarizing muscle relaxant used to promote a neuromuscular blockade?

A) Relaxation of facial muscles
B) Relaxation of arms and legs
C) Relaxation of trunk muscles
D) Relaxation of diaphragm

Question 15

Discontinuation of intrathecal baclofen therapy should be gradual in order to prevent:

A) Severe hypotension
B) Hyperglycemia
C) Rebound spasticity
D) Hypernatremia

Question 16

Peripheral skeletal muscle relaxation can be achieved by using which medications?

A) Dantrolene and pancuronium
B) Baclofen and dantrolene
C) Pancuronium and succinylcholine
D) Baclofen and diazepam

Question 17

The duration of action of many nondepolarizing skeletal muscle relaxants will differ according to which pharmacokinetics property?

A) Excretion
B) Metabolism
C) Absorption
D) Distribution

Question 18

The major toxicity associated with neuromuscular blocker overdose is:

A) Respiratory muscle paralysis
B) Cardiovascular collapse
C) Hypercalcemia
D) Hyponatremia

Question 19

The antidote given for depolarizing muscle blocker toxicity is:

A) Pancuronium
B) Succinylcholine
C) Anticholinesterase drug
D) None available

Question 20

Two types of receptors that can be manipulated to reduce spasticity are:

A) Alpha-1 adrenergic and GABA
B) Serotonin and GABA
C) Histamine and cholinergic
D) Alpha-2 adrenergic and GABA