Deck 7: Drugs Affecting the Parasympathetic Nervous System

Question 1

What class of drugs is preferred for increasing urinary flow in patients with benign prostatic hyperplasia?

A) Beta-blockers
B) Alpha-blockers
C) Muscarinic blockers
D) Nicotinic blockers

Answer 1

Alpha-blockers

Question 2

Myasthenia gravis is diagnosed by intravenous injection of:

A) Edrophonium
B) Neostigmine
C) Pyridostigmine
D) Ambenonium

Answer 2

Edrophonium

Question 3

This type of cholinergic receptor is not associated with the autonomic nervous system:

A) Muscarinic
B) Ganglionic
C) Nicotinic-n
D) Nicotinic-m

Answer 3

Nicotinic-m

Question 4

What are two muscle types that are activated via cholinergic activity at muscarinic receptors?

A) Smooth and cardiac muscle
B) Smooth and skeletal muscle
C) Skeletal and cardiac muscle
D) Actin and myosin myofilaments

Question 5

Pyridostigmine is useful in treating patients with myasthenia gravis because:

A) Increased formation of acetylcholine occurs
B) Increased production and secretion of acetylcholine occur
C) Irreversible inhibition of acetylcholinesterase decreases levels of acetylcholine
D) Reversible inhibition of acetylcholinesterase increases levels of acetylcholine

Question 6

Acetylcholinesterase activity takes place primarily in what location?

A) Neuronal synapse
B) Inside presynaptic vesicles
C) Inside presynaptic axon terminal
D) On the membrane of the postsynaptic neuron

Question 7

Farmer Brown developed cholinergic crisis after spraying his fields with insecticide.Why wouldn't pyridostigmine be an efficient treatment?

A) Pyridostigmine will irreversibly bind to the cholinergic receptor.
B) Pyridostigmine will reversibly bind to the cholinergic receptor.
C) Pyridostigmine does not have an effect on irreversible anticholinesterases.
D) Pyridostigmine does not have an effect on reversible anticholinesterases.

Question 8

Which type of cholinergic receptor would need to be stimulated for activation of the gastrointestinal system after surgery?

A) Ganglionic
B) Nicotinic-m
C) Nicotinic-n
D) Muscarinic

Question 9

What triggers the release of acetylcholine from a neuron?

A) Hormonal control
B) Enzyme activity
C) Nerve stimulation
D) Regulator proteins

Question 10

What is a desirable property that would need to be enhanced in developing a new direct-acting cholinergic drug?

A) Longer duration of action
B) Shorter duration of action
C) Quicker absorption
D) Quicker elimination

Question 11

Indirect-acting anticholinesterase drugs are effective at treating glaucoma because they produce:

A) Mydriasis
B) Miosis
C) Cycloplegia
D) Diplopia

Question 12

The injection of botulinin toxin will affect which type of cholinergic receptor?

A) Ganglionic
B) Muscarinic
C) Nicotinic-m
D) Nicotinic-n

Question 13

Since quaternary amines do not cross the blood-brain barrier,one would expect these indirect-acting cholinergic drugs to have:

A) No effect
B) Potentiated effects
C) Increased side effects
D) Decreased side effects

Question 14

Name a direct-acting cholinergic drug that is used systemically.

A) Pilocarpine
B) Muscarine
C) Bethanechol
D) Acetylcholine

Question 15

Neostigmine is an indirect-acting anticholinesterase drug used to treat urinary retention by:

A) Stimulating bladder contractions
B) Inhibiting the release of ADH
C) Stimulating the thirst mechanism
D) Increasing the release of ADH

Question 16

A middle-stage Alzheimer's patient susceptible to side effects would benefit best from which medication?

A) Tacrine
B) Memantine
C) Galantamine
D) Rivastigmine

Question 17

Which medication is preferred for treating all stages of Alzheimer's disease?

A) Galantamine
B) Donepezil
C) Rivastigmine
D) Tacrine

Question 18

Cholinergic drugs that exert their effect at the receptor belong to which class of medications?

A) Reversible indirect-acting cholinergic drugs
B) Irreversible indirect-acting cholinergic drugs
C) Ganglionic stimulants
D) Direct-acting cholinergic drugs

Question 19

Botulinin toxin can be used to reduce wrinkles and lines on the face by inducing what type of paralysis?

A) Intermittent
B) Irreversible
C) Flaccid
D) Rigid

Question 20

Intravenous injection of acetylcholine will not be successful in suppressing cholinergic activity due to the presence of:

A) Phosphodiesterase
B) Pseudoacetylcholinesterase
C) Serum albumin
D) Hemoglobin