Deck 45: Antineoplastic Agents

Question 1

_____ is a gonadotropin inhibitor that is administered by nasal spray.

A) Degarelix
B) Goserelin
C) Triptorelin
D) Nafarelin

Answer 1

Nafarelin

Question 2

Tumor cells detach from their location and relocate in other areas of the body that are referred to as _____.

A) origination sites
B) fringe sites
C) secondary sites
D) peripheral sites

Answer 2

secondary sites

Question 3

_____ is the primary course of therapy used to treat diffuse tumors.

A) Dietary supplementation
B) Surgery
C) Radiation
D) Chemotherapy

Answer 3

Chemotherapy

Question 4

Which of the following approaches is commonly used to treat cancer?

A) Surgery
B) Radiation
C) Chemotherapy
D) All of these

Question 5

A medication that can be taken prophylactically by women who have a family history of developing breast cancer is:

A) anastrozole.
B) tamoxifen.
C) rituximab.
D) flutamide.

Question 6

An advantage of raloxifene over tamoxifen is that:

A) it does not stimulate proliferation of the uterine lining.
B) it does not lead to cytotoxicity.
C) it reduces vasomotor hot flashes.
D) it increases blood clotting factors.

Question 7

A patient experiences severe tissue damage after receiving an intravenous injection of a chemotherapy agent.This is most likely a result of:

A) overdose of kanamycin.
B) extravasation of doxorubicin.
C) compromised liver function.
D) problems with renal tubular reabsorption.

Question 8

Marvin is diagnosed with lung cancer and is being treated with chemotherapy.He is hydrated and administered mesna disulfide before the antineoplastic drug.Marvin is being treated with _____.

A) busulfan
B) procarbazine
C) ifosfamide
D) carboplatin

Question 9

Mr.Smith was temporarily taken off chemotherapy despite responding very well to the treatment.This is often practiced when using chemotherapy because:

A) additional time allows medical staff to test for remission.
B) additional time allows for recovery of the normal cells.
C) additional time allows cell-cycle nonspecific drugs to be effective.
D) additional time allows the immune system to fight off the tumor.

Question 10

The different forms of cancer can be classified into:

A) solid tumors and diffuse tumors.
B) solid tumors and vesicular tumors.
C) vesicular tumors and diffuse tumors.
D) lymphatic tumors and diffuse tumors.

Question 11

A leukemia patient is currently not responding to cyclophosphamide despite having favorable results with the drug in the past.The patient is most likely to have developed a problem in his _____.

A) pancreas
B) kidneys
C) hypothalamus
D) liver

Question 12

Tumor growth inhibition by the Vinca alkaloids occurs through:

A) inhibition of DNA transcription.
B) inhibition of protein translation.
C) metaphase arrest.
D) anaphase arrest.

Question 13

Which two systems do tumor cells use to metastasize?

A) Digestive system and lymphatic system
B) Respiratory system and lymphatic system
C) Circulatory system and lymphatic system
D) Circulatory system and nervous system

Question 14

Methotrexate is a chemotherapeutic medication that inhibits cell reproduction by:

A) causing metaphase arrest.
B) inhibiting folic acid reductase.
C) binding to the mitotic microtubules.
D) inhibiting protein translation.

Question 15

Which of the following types of drugs are used to treat brain tumors?

A) Nitrosoureas
B) Nitrogen mustard
C) Platinum derivatives
D) Folic acid antagonists

Question 16

Why would leucovorin be administered after methotrexate therapy?

A) To resume blood cell production
B) To reduce oxygen supply to cancer cells
C) To reestablish normal blood glucose levels
D) To reduce plasma cortisol levels

Question 17

A medication that can be taken prophylactically by women who have a family history of developing breast cancer is:

A) anastrozole.
B) tamoxifen.
C) rituximab.
D) flutamide.

Question 18

Which of the following classes of drugs is a new approach to cancer chemotherapy?

A) Antimetabolite
B) Polyclonal antibodies
C) Monoclonal antibodies
D) Alkylating drugs

Question 19

Jimenez is not responding well to chemotherapy.The cancer cells continue to grow despite the chemotherapy.Which of the following is most likely to be the next step in his treatment?

A) Initiation of radiation therapy
B) Switching to a different chemotherapy drug in the same class of antineoplastic drugs
C) Initiation of combination therapy
D) Switching to a drug that belongs to a different class of antineoplastic drugs

Question 20

Mrs.Smith's treatment for cancer has showed promise.The first treatment session has yielded a 50 percent reduction in the number of tumor cells.Identify the statement that best explains why only one more treatment session will not be enough to eradicate all the cancer cells in Mrs.Smith.

A) Cancer treatment eradicates cells by percentage, not number.
B) Cancer treatment only prolongs a patient's life and cannot completely cure a patient.
C) Cancer cells grow at a faster rate than normal cells.
D) Cancer cells can only be eliminated over the course of several weeks.

Question 21

_____ is the preferred route for the treatment of choriocarcinoma using methotrexate.

A) Oral administration
B) Subcutaneous injection
C) Intramuscular injection
D) Intravenous administration

Question 22

Which of the following is used to treat colorectal cancer?

A) Dactinomycin
B) Irinotecan
C) Idarubicin
D) Bleomycin

Question 23

Sebastian is diagnosed with acute lymphocytic leukemia.To avoid suppressing the bone marrow,he is administered a drug that is derived from bacteria.Shortly after the treatment,he develops an allergy to the drug.He is switched to another drug that is also derived from bacteria.Which of the following drugs is now being used to treat Sebastian?

A) Vincristine
B) Pegaspargase
C) Etoposide
D) Topotecan

Question 24

Cyclophosphamide and ifosfamide are metabolized by the liver to produce _____,which is toxic.

A) acrolein
B) viniferal
C) hexanal
D) iridodial

Question 25

Oxaliplatin is used to treat _____.

A) lung cancer
B) multiple myeloma
C) leukemia
D) Hodgkin's disease

Question 26

Emma has been diagnosed with lung cancer.She has been scheduled to undergo chemotherapy.Before the treatment is started,she is administered mesna disulfide.Which of the following drugs is being used to treat Emma?

A) Isofamide
B) Oxaliplatin
C) Carmustine
D) Temozolomide

Question 27

Miller undergoes chemotherapy for cancer.He experiences nausea and vomiting shortly after the first cycle of treatment.Several weeks later,he also develops anemia,malnutrition,and hyperkalemia.His doctor diagnoses him with uremia.He explains that this has occurred due to renal toxicity and says that Miller cannot continue to be treated with the same drug.Which of the following types of cancer does Miller have?

A) Pancreatic cancer
B) Testicular cancer
C) Non-Hodgkin's lymphoma
D) Multiple myeloma

Question 28

_____ inhibits the enzyme topoisomerase I to cause cell death.

A) Docetaxel
B) Teniposide
C) Irinotecan
D) Doxorubicin

Question 29

_____ is classified as an antibiotic but is too toxic to treat bacterial infections.

A) Dactinomycin
B) Irinotecan
C) Paclitaxel
D) Vincristine

Question 30

Busulfan is used to treat _____.

A) chronic myelogenous leukemia
B) multiple myeloma
C) non-Hodgkin's lymphoma
D) Hodgkin's disease

Question 31

Madison is administered methotrexate to treat her cancer.She suffers from meningeal inflammation after undergoing therapy.This indicates that methotrexate was administered to Madison _____.

A) intravenously
B) using a subcutaneous injection
C) using an intramuscular injection
D) intrathecally

Question 32

_____ is used in combination with capecitabine to treat metastatic and advanced breast cancer.

A) Fludarabine
B) Irinotecan
C) Paclitaxel
D) Ixabepilone

Question 33

Which of the following is used to treat Wilms' tumor?

A) Dactinomycin
B) Pegaspargase
C) Idarubicin
D) Topotecan

Question 34

_____ is used to treat hairy cell leukemia.

A) Cytarabine
B) Methotrexate
C) Cladribine
D) Fluorouracil

Question 35

Diego has been diagnosed with Hodgkin's lymphoma.He is administered a drug that is derived from a plant during his first session of chemotherapy.After the session,he notices a tingling sensation in his fingers.He also observes that his physical responses have slowed due to deteriorated reflexes.Which of the following drugs has been used to treat Diego?

A) Vincristine
B) Vinorelbine
C) Etoposide
D) Topotecan