Question 1

A diagnosis of Angelman syndrome in a child is supported by which assessment findings? (Select all that apply.)&#10;A) Small feet and hands&#10;B) Profound cognitive dysfunction&#10;C) Obesity&#10;D) Ataxic gait&#10;E) History of seizures

Accepted Answer

A child diagnosed with Angelman syndrome demonstrates a characteristic posture,bouts of uncontrolled laughter,severe mental retardation,seizures,and an ataxic gait.

Question 2

Prader-Willi syndrome causes a chromosomal defect that is:&#10;A) Initiated by postnatal exposure to a virus&#10;B) Inherited from the father&#10;C) Related to maternal alcohol abuse&#10;D) Transferred from mother to child

Accepted Answer

Prader-Willi syndrome can be caused by a 4 Mb deletion of chromosome 15q when inherited from the father.The other options do not accurately identify the reason for the chromosomal damage that causes Prader-Willi syndrome.

Question 3

Hypomethylation and the resulting effect on oncogenes result in a(an):&#10;A) Decrease in the activity of the oncogene, thus suppressing cancer development&#10;B) Deactivation of MLH1 to halt DNA repair&#10;C) Increase in tumor progression from benign to malignant&#10;D) Over-expression of microRNA, resulting in tumorigenesis

Accepted Answer

Tumor cells typically exhibit hypomethylation (decreased methylation),which can increase the activity of oncogenes.Hypomethylation increases as tumors progress from benign neoplasms to malignancy.Only the correct option accurately describes hypomethylation and its resulting effects.

Question 4

Genes responsible for the maintenance of all cells are referred to as:&#10;A) Universal&#10;B) Managerial&#10;C) Housekeeping&#10;D) Executive

Accepted Answer

A small percentage of genes,termed housekeeping genes,are necessary for the function and maintenance of all cells.The remaining options do not accurately refer to these cells.

Question 5

A malfunction in DNA methylation can lead to:&#10;A) Hypothyroidism&#10;B) Blindness&#10;C) Cancer&#10;D) Diabetes mellitus

Accepted Answer

Aberrant methylation can lead to silencing of tumor-suppressor genes in the development of cancer.No research supports a connection between hypothyroidism,blindness,or diabetes mellitus to a malfunctioning of DNA methylation.

Question 6

Which term refers to the silenced gene of a gene pair?&#10;A) Activated&#10;B) Altered&#10;C) Mutated&#10;D) Imprinted

Accepted Answer

Gene silencing,a process during which genes are predictably silenced,depending on which parent transmits them,is known as imprinting; the transcriptionally silenced genes are then said to be imprinted.The remaining options do not accurately identify this process.

Question 7

What is the belief regarding twins who adopt dramatically different lifestyles?&#10;A) They may experience very different aging processes.&#10;B) They will retain very similar methylation patterns.&#10;C) They will experience identical phenotypes throughout their lifespans.&#10;D) They may never demonstrate similar DNA sequences of their somatic cells.

Accepted Answer

Twins with significant lifestyle differences (e.g.,smoking versus nonsmoking),accumulate large numbers of differences in their methylation patterns.The twins,despite having identical DNA sequences,become more and more different as a result of epigenetic changes,which in turn affect the expression of genes.These results,along with findings generated in animal studies,suggest that changes in epigenetic patterns may be an important part of the aging process.They will not experience identical phenotypes throughout their lifespans.

Question 8

A child's diagnosis of Beckwith-Wiedemann syndrome is supported by the presence of: (Select all that apply.)&#10;A) An omphalocele&#10;B) Neonatal hypoglycemia&#10;C) Creased earlobes&#10;D) Low birth weight&#10;E) A large tongue

Accepted Answer

Beckwith-Wiedemann syndrome is usually identifiable at birth because the child exhibits a large size for gestational age,neonatal hypoglycemia,a large tongue,creases on the earlobe,and omphalocele.

Question 9

Which statement is true regarding the embryonic development of stem cells?&#10;A) They are already differentiated.&#10;B) They are referred to as housekeeping genes.&#10;C) They already demonstrate DNA sequencing.&#10;D) They are said to be pluripotent.

Accepted Answer

Early in embryonic development,all cells of the embryo have the potential to become any type of cell in the fetus or adult.These embryonic stem cells are said to be pluripotent.The remaining options are not true statements regarding embryonic stem cell development.

Question 10

When microRNA (miRNA)are methylated their messenger RNA (mRNA)targets are over-expressed,the resulting effect on existing cancer would be:&#10;A) Cell death&#10;B) Metastasis&#10;C) Remission&#10;D) Relapse

Accepted Answer

When miRNA genes are methylated,their mRNA targets are over-expressed,and this over-expression has been associated with metastasis.of the described effect on mRNA targets on existing cancer does not result in any of the other options.

Question 11

When a chromosome lacking 4 Mb is inherited from the mother,the child is at risk for developing which syndrome?&#10;A) Prader-Willi&#10;B) Angelman&#10;C) Beckwith-Wiedemann&#10;D) Russell-Silver

Accepted Answer

The answer of When a chromosome lacking 4 Mb is...

Question 12

The difference between DNA sequence mutations and epigenetic modifications is:&#10;A) DNA sequence mutations can be directly altered.&#10;B) Leukemia is a result of only DNA sequence mutation.&#10;C) Epigenetic modifications can be reversed.&#10;D) No known drug therapies are available for epigenetic modifications.

Accepted Answer

The answer of The difference between DNA sequence mutations and...

Question 13

What genetic process is likely responsible for the occurrence of asthma in only one of a pair of identical twins?&#10;A) Epigenetic modifications&#10;B) Genomic imprinting&#10;C) Transgenerational inheritance&#10;D) Methylation

Accepted Answer

The answer of What genetic process is likely responsible for...

Question 14

The shape of the face of a child diagnosed with Russell-Silver syndrome is likely to be:&#10;A) Round&#10;B) Square&#10;C) Triangular&#10;D) Elongated

Accepted Answer

The answer of The shape of the face of a...

Deck 6: Epigenetics and Disease