Deck 16: Quantitative and Qualitative Platelet Disorders

Question 1

Red cell morphology such as the one at the tip of the pointer are associated with:

A) von Willebrand's disease
B) Glanzmann's thrombasthenia
C) Thrombotic thrombocytopenic purpura
D) All of the above

Answer 1

C

Question 2

Aspirin therapy irreversibly inhibits the synthesis of:

A) ATP
B) GP 1
C) Prostaglandins
D) GP IIb and IIIa

Answer 2

C

Question 3

A platelet release defect in which there is a severe lack of alpha granules in platelets is known as:

A) Bernard-Soulier syndrome
B) Chediak-Higashi syndrome
C) Glanzmann's thrombasthenia
D) Gray platelet syndrome

Answer 3

D

Question 4

Desmopressin acetate (DDAVP) is an effective treatment for vWD because it:

A) Causes platelets to be mobilized from the spleen
B) Activates the intrinsic system
C) Demobilizes factor VIII
D) Causes the release of endothelial vWF

Question 5

The presence of thrombocytopenia and giant platelets on the peripheral smear of a patient is characteristic of:

A) Classic von Willebrand's disease
B) Hemophilia A
C) Glanzmann's thrombasthenia
D) Bernard-Soulier syndrome

Question 6

Several hours after birth, a baby boy develops the following symptoms, petechiae, purpura, and hemorrhage.The platelet count is 18,000.The most likely explanation is:

A) Drug-induced thrombocytopenia
B) Secondary thrombocytopenia
C) Isoimmune neonatal thrombocytopenia
D) Neonatal DIC

Question 7

In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

A) The organ most affected is the spleen.
B) The toxin responsible for this syndrome is produced by E. coli O157:H7.
C) Impaired neurological function is one of the primary symptoms.
D) Platelets are permanently impaired.

Question 8

The autoantibody generated in ITP is directed against:

A) vWF
B) Collagen
C) GP IIb/IIIa, GP Ib/IX
D) Fibrinopeptides A and B

Question 9

The correct anticoagulant-to-blood ratio for coagulation samples is:

A) 4:1
B) 9:1
C) 1:9
D) 1:4

Question 10

The anticoagulant of choice for routine coagulation procedure is:

A) Sodium oxalate
B) Sodium citrate
C) Heparin
D) Sodium fluoride

Question 11

Which the following test results is normal in a patient with classic von Willebrand's disease?

A) Bleeding time
B) Activated partial thromboplastin time
C) Platelet count
D) Factor VIII and vWF levels

Question 12

A decreased platelet count is most often anticipated when a patient demonstrates:

A) Rectal bleeding
B) Epistaxis
C) Genitourinary bleeding
D) Severe hemorrhage

Question 13

A platelet release defect in which there is a severe deficiency of dense granules in platelets is known as:

A) Chediak-Higashi syndrome
B) Hermansky-Pudlak syndrome
C) Wiskott-Aldrich syndrome
D) Bernard-Soulier syndrome

Question 14

All of the following are associated with platelet disorders except:

A) Thrombocytopenia
B) Deep muscle hemorrhages
C) Epistaxis and menorrhagia
D) Abnormal platelet morphology

Question 15

Thrombocytosis is defined as a platelet count that is:

A) Greater than 450 $\times$ 10⁹/L
B) Less than 450 $\times$ w10⁹/L
C) Greater than 600 $\times$ 10⁹/L
D) Less than 300 $\times$ 10⁹/L

Question 16

Which of the following are platelet adhesion disorders?

A) von Willebrand's disease and Glanzmann's thrombasthenia
B) von Willebrand's disease and Bernard-Soulier
C) Glanzmann's thrombasthenia and Bernard-Soulier
D) Glanzmann's thrombasthenia and congenital fibrinogenemia

Question 17

Which of the following causes irreversible inactivation of platelets?

A) Heparin
B) Coumadin
C) Aspirin
D) Vitamin K

Question 18

Platelet aggregation cannot occur if ___is absent.

A) vWF
B) GP IIb/IIIa
C) cadmium
D) GP Ib

Question 19

In thrombotic thrombocytopenic purpura, which of the following statements is the most accurate?

A) It is associated with E. coli O157:H7.
B) It is associated with fever, renal failure, and neurological complications.
C) The organ most affected is the kidney.
D) More males are affected than females

Question 20

Which of the following conditions may result in thrombocytosis?

A) Polycythemia vera (PCV)
B) Acute leukemia
C) Sickle cell disease
D) TTP

Question 21

Hyperviscosity syndrome and paraproteinemia are associated with:

A) Chediak-Higashi syndrome
B) Wiskott-Aldrich syndrome
C) Multiple myeloma and Waldenström's macroglobulinemia
D) ITP

Question 22

Platelets from patients with these two disorders will not aggregate with ristocetin.

A) Glanzmann's syndrome and von Willebrand's
B) Glanzmann's syndrome and Chediak-Higashi
C) HUS and Bernard-Soulier syndrome
D) von Willebrand's disease and Bernard-Soulier

Question 23

A coagulation disorder commonly associated with umbilicus bleeding and post-circumcision bleeding is known as:

A) von Willebrand's disease
B) Bernard-Soulier syndrome
C) Glanzmann's thrombasthenia
D) Idiopathic thrombocytopenic purpura

Question 24

The single best predictive assay for von Willebrand factor is:

A) Ristocetin co-factor activity
B) Bleeding time
C) aPTT
D) Platelet count

Question 25

Which of the following is an autoimmune thrombocytopenic disease process?

A) Chronic idiopathic thrombocytopenic purpura
B) Hemolytic uremic syndrome
C) von Willebrand's disease
D) Thrombocytopenia with absent radii