Deck 14: The Myelodysplastic Syndromes

Question 1

All of the following are associated with the development of the MDSs except:

A) Alkylating therapy
B) Benzene exposure
C) Alcoholism
D) Radiation

Answer 1

C

Question 2

The most common hematological malignancy in the adult population is:

A) Acute leukemia
B) Multiple myeloma
C) Myelodysplastic syndrome
D) Chronic leukemias

Answer 2

C

Question 3

The cell at the tip of the pointer is:

A) A basophil
B) A malignant cell
C) A degenerating neutrophil
D) Not a cell; it's an artifact

Answer 3

C

Question 4

The correct name for the cell at the end of the pointer is a:

A) Ringed sideroblast
B) Reticulocyte
C) Giant platelet
D) Siderocyte

Question 5

Refractory anemia is an anemia that:

A) Has more than 5% blasts in the peripheral blood
B) Is resistant to treatment
C) Will usually demonstrate a hypoplastic bone marrow
D) Demonstrates a 17g deletion routinely

Question 6

The bone marrow and peripheral smear of a patient with an MDS will show dysplastic changes in _over time.

A) white cells
B) red cells
C) platelets
D) All of the above

Question 7

The cell at the tip of the pointer is a:

A) Hairy cell
B) Basket cell
C) Degenerating lymphocyte
D) Giant platelet

Question 8

All of the following are features of the myelodysplastic syndromes except:

A) Anemia
B) Organomegaly
C) Dysplasia
D) Hypercellular marrow

Question 9

One of the key white cell features in MDS is:

A) Hypersegmented neutrophils
B) Auer rods
C) Dohle bodies
D) Pseudo Pelger-Huët

Question 10

Which of the following bone marrow blast percentages will be consistent with the FAB classification of refractory anemia with excess of blasts (RAEB)?

A) 5% to 20%
B) 20% to 30%
C) Greater than 30%
D) Less than 5%

Question 11

The most effective means of treating iron overload in the myelodysplastic syndromes is:

A) Therapeutic phlebotomy
B) Limiting iron-containing foods
C) Iron chelation therapy
D) Fasting

Question 12

A large percentage of the MDSs end in an acute leukemia.

Question 13

Reticulocytopenia is a feature of MDS.Which one of the following is the mechanism behind this process?

A) Heavy tumor burden
B) Marrow aplasia
C) Ineffective erythropoiesis
D) Toxic effects

Question 14

The FAB classification of the MDSs include CML.

Question 15

The blast count in most individuals with MDS is:

A) Less than 10%
B) Less than 40%
C) Less than 5%
D) Less than 20%

Question 16

Typically, patients with MDS will exhibit partial or complete absence of:

A) Chromosomes 5 and 7
B) Chromosomes 8 and 12
C) The Y chromosome
D) Dysplasia

Question 17

Deleted 5q MDS is primarily seen in male patients.

Question 18

The morphological classification of anemia in the myelodysplastic syndromes is:

A) Normocytic, normochromic
B) Microcytic, hypochromic
C) Macrocytic, normochromic
D) Microcytic, normochromic

Question 19

Which of the following chromosome disorders in MDS has a poor predictive influence?

A) Chromosome 7 disorder
B) Trisomy 12
C) Trisomy 13
D) 17q deletion

Question 20

All of the following are dysplastic changes of platelets frequently seen in MDS except:

A) Abnormal granulation
B) Micromega karyocytes
C) Giant platelets
D) Platelet satellitism