Deck 15: Overview of Hemostasis and Platelet Physiology

Question 1

Which of the following proteins is not made in the liver?

A) Anti-hemophiliac factor
B) Prothrombin
C) Fibrinogen
D) von Willebrand factor

Answer 1

D

Question 2

Which factor is involved in contact activation?

A) Factor X
B) Fibrinogen
C) Fitzgerald factor
D) Factor II

Answer 2

C

Question 3

Which of the following is not a component of the fibrinolytic system?

A) Thrombin
B) Plasmin
C) Tissue-type plasminogen activator (tPA)
D) Urokinase

Answer 3

A

Question 4

The prothrombin group of factors consists of factors:

A) I, V, VIII, and XIII
B) XI, XII, prekallikrein, and HMWK
C) II, VII, IX, and X
D) III, VIII, IX, and X

Question 5

Identify the cell at the tip of the pointer (bone marrow smear).

A) Myeloblast
B) Megakaryocyte
C) Nucleated red cell
D) Reed Sternberg cell

Question 6

The first response of a cut vessel is:

A) Vasoconstriction
B) Platelet aggregation
C) Activation of the intrinsic pathway
D) Vasodilation

Question 7

Which of the following ratios of anticoagulant to blood is acceptable for most coagulation procedures?

A) 1:4
B) 5:1
C) 1:9
D) 9:1

Question 8

A decreased platelet count is most often anticipated when a patient demonstrates:

A) Thrombosis
B) Petechiae
C) Hemarthrosis
D) Glossitis

Question 9

In the prothrombin test, the patient's citrated plasma is combined with:

A) Phospholipids
B) Thromboplastin only
C) Ca²⁺ and actin
D) Ca²⁺ and thromboplastin

Question 10

Platelets are synthesized in the:

A) Liver
B) Spleen
C) Lymph glands
D) Bone marrow

Question 11

The vasoconstrictor substance released from the platelets at the site of injury is:

A) Thrombin
B) Thromboxane A₂
C) Adenosine diphosphate
D) Prostacyclin

Question 12

The average lifespan of a platelet in a normal adult is:

A) 1 to 5 days
B) 5 to 7 days
C) 7 to 10 days
D) 18 to 21 days

Question 13

Tissue factor pathway inhibitor (TFPI):

A) Prevents activation of factor X by VIIa
B) Activates the common pathway
C) Inhibits fibrinolysis
D) Inhibits the kallikrein proteins

Question 14

Which organ is responsible for sheltering 20% of the total platelet volume in the circulation?

A) Kidney
B) Adrenal gland
C) Spleen
D) Liver

Question 15

Platelet aggregation is dependent on the presence of:

A) Calcium ions
B) Sodium citrate
C) Magnesium
D) Potassium

Question 16

The anticoagulant known as heparin:

A) Inhibits PF3 activity
B) Inhibits thrombin activity
C) Degrades antithrombin activity
D) Chelates calcium

Question 17

The two inhibitors that keep the activation of coagulation under control are:

A) TFPI and thrombomodulin
B) Protein C and protein S
C) Protease inhibitors and the protein C pathway
D) Alpha 2 macroglobulin and alpha 1 antitrypsin

Question 18

There are four phases in regards to platelet function.The correct order of occurrence from the beginning to end is:

A) Adhesion, release, aggregation, stabilization
B) Aggregation, adhesion, stabilization, release
C) Adhesion, aggregation, release, stabilization
D) Release, aggregation, adhesion, stabilization

Question 19

Which factor is measured by both the PT and the aPTT?

A) Factor VIII
B) Factor IX
C) Factor V
D) Factor XIII

Question 20

The main substrate of the coagulation system is:

A) Calcium
B) ADP
C) Collagen
D) Fibrinogen

Question 21

Match the factor with its correct name.
a.Stabile factor
b.Labile factor
c.Thromboplastin
d.Calcium
e.Anti-hemophiliac factor
f.Fibrinogen
g.Prothrombin
Factor I

Question 22

Fibrinolysis is controlled by the:

A) Plasminogen activator system
B) Intrinsic system
C) Thrombin feedback activation system
D) Feedback inhibition system

Question 23

Match the factor with its correct name.
a.Stabile factor
b.Labile factor
c.Thromboplastin
d.Calcium
e.Anti-hemophiliac factor
f.Fibrinogen
g.Prothrombin
Factor IV

Question 24

Match the factor with its correct name.
a.Stabile factor
b.Labile factor
c.Thromboplastin
d.Calcium
e.Anti-hemophiliac factor
f.Fibrinogen
g.Prothrombin
Factor II

Question 25

Match the factor with its correct name.
a.Stabile factor
b.Labile factor
c.Thromboplastin
d.Calcium
e.Anti-hemophiliac factor
f.Fibrinogen
g.Prothrombin
Factor VII

Question 26

Therapeutic thrombolytic agents include:

A) tPA
B) Streptokinase
C) Urokinase
D) All of the above
Matching

Question 27

Match the factor with its correct name.
a.Stabile factor
b.Labile factor
c.Thromboplastin
d.Calcium
e.Anti-hemophiliac factor
f.Fibrinogen
g.Prothrombin
Factor V

Question 28

The fibrinogen group of coagulation factors include:

A) Factors I, V, VII, XIII
B) Factors II, VII, IX, X
C) Factors III, VIII, IX, X
D) Factors XI and XII

Question 29

Match the factor with its correct name.
a.Stabile factor
b.Labile factor
c.Thromboplastin
d.Calcium
e.Anti-hemophiliac factor
f.Fibrinogen
g.Prothrombin
Factor III

Question 30

All of the coagulation factors have autosomal inheritance features except:

A) Factors I and XII
B) Factors III and VIII
C) Factors VIII and IX
D) Factors V and VII