Deck 11: Acute Leukemias

Question 1

___is the rarest form of the AMLs.

A) M1
B) M4
C) M6
D) M7

Answer 1

D

Question 2

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

A) Hypercellular bone marrow with greater than 20% blasts
B) Hypercellular bone marrow with less than 20% blasts
C) Hypocellular bone marrow with greater than 20% blasts
D) Hypocellular bone marrow with less than 20% blasts

Answer 2

A

Question 3

The presence of CD2, CD5, and CD7 and the absence of CD10 is seen in:

A) B lymphocytes
B) T lymphocytes
C) Myeloblasts
D) Monoblasts

Answer 3

B

Question 4

The leukemia with a predominance of WBC cells positive for CD41 is:

A) AMML
B) AML
C) AMonoL
D) AMegL

Question 5

The L3 classification of leukemia is defined by:

A) Small homogeneous blasts
B) Large vacuolated blasts
C) Large heterogeneous blasts
D) Predominance of prolymphocytes

Question 6

Which of the following is characteristic of Auer rods?

A) Composed of fused primary granules
B) Predominantly seen in ALL
C) Predominantly seen in HCL
D) Composed of specific granules

Question 7

The monoclonal marker that is often positive in T-ALL is:

A) CD1
B) CD7
C) CD10
D) CD41

Question 8

The cells pictured above are most consistent with:

A) Acute myeloid leukemia
B) Acute myelomonocytic leukemia
C) Acute lymphoblastic leukemia
D) Acute erythroid leukemia

Question 9

The cells pictured above are most consistent for:

A) Acute myeloid leukemia
B) Acute myelomonocytic leukemia
C) Acute lymphoblastic leukemia
D) Acute erythroid leukemia

Question 10

The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:

A) Replacement of normal marrow precursors by leukemic cells
B) Decrease in functional leukocytes causing infection
C) Hemorrhage secondary to thrombocytopenia
D) Decreased erythropoietin production

Question 11

The WBC count is 20 $\times$ 10⁹/L, with 89% blasts, 7% segs, and 4% monos.The blasts are relatively large and have abundant cytoplasm.More than 90% of them are positive with the NSE stain, and an occasional blast is positive with Sudan Black B.What is the possible diagnosis?

A) AML, type M1
B) AML, type M3
C) AML, type M4
D) AML, type M5

Question 12

The structure at the end of the pointer is a(n):

A) Auer rod
B) Dohle body
C) Engulfed bacteria
D) None of the above

Question 13

The t(15:17)(q22;q12) is associated with which of the following leukemias?

A) Acute promyelocytic leukemia
B) Acute myelomonocytic leukemia
C) Acute lymphocytic leukemia
D) Acute myelocytic leukemia

Question 14

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14 and CD4 positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

A) ALL
B) AMonoL
C) AMML
D) AML

Question 15

A patient with AML is likely to have a cytochemical stain panel that is positive for:

A) Sodium fluoride with tartrate resistance
B) MPO, SBB, specific esterase
C) MP0, SBB, nonspecific esterase
D) SBB and TdT

Question 16

Pure erythroid leukemia is defined as:

A) Erythroid precursors greater than 30%, myeloblasts less than 20%
B) Erythroid precursors greater than 50%, myeloblasts less than 40%
C) Erythroid precursors less than 50%
D) Erythroid precursors greater than 80%

Question 17

Migration to extramedullary sites is a feature of which of the following leukemias?

A) Acute progranulocytic leukemia
B) Acute myelocytic leukemia
C) Acute monocytic leukemia
D) Acute lymphocytic leukemia

Question 18

Acute leukemic processes are marked by:

A) Slow onset, slow progression, anemia
B) Rapid onset anemia, thrombocytopenia
C) Splenomegaly
D) Less than 30% in the BM

Question 19

Which CD marker best represents the earliest progenitor cells?

A) CD11
B) CD19
C) CD34
D) CD57

Question 20

A patient presents with generalized lymphadenopathy and a WBC of 100 $\times$ 10⁹/L.This hematologic picture would most likely be seen in:

A) Chronic lymphocytic leukemia
B) Acute lymphocytic leukemia
C) Burkitt's lymphoma
D) Hairy cell leukemia

Question 21

______may arise as a blastic transformation in patients with CML.

A) Acute basophilic leukemia
B) Acute myelofibrosis
C) Acute lymphocytic leukemia
D) Erythroleukemia

Question 22

_is predominantly a disease of children.

A) AML
B) CML
C) ALL
D) CLL

Question 23

Low-risk ALL pediatric clinical trials require the WBC count to be less than:

A) 20 $\times$ 10⁹/L
B) 50 $\times$ 10⁹/L
C) 60 $\times$ 10⁹/L
D) 75 $\times$ 10⁹/L

Question 24

Greater than __of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

A) 10%
B) 20%
C) 25%
D) 30%

Question 25

Pediatric patients with ALL have an overall complete remission rate of:

A) 50%
B) 65%
C) 75%
D) 95%