Deck 3: Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Question 1

The last nucleated stage of erythrocytic maturation is the:

A) Pronormoblast
B) Orthochromic normoblast
C) Polychromatophilic normoblast
D) Basophilic normoblast

Answer 1

B

Question 2

One of the key morphological features of the nucleated red cell stages is:

A) Basophilic cytoplasm through every stage of maturation
B) Granules in the cytoplasm
C) A round nucleus
D) An increase in size as the cell matures

Answer 2

C

Question 3

Most hypochromic cells will have an MCHC that is:

A) Greater than 36%
B) Less than 30%
C) Greater than 27%
D) Less than 27%

Answer 3

B

Question 4

The erythrocyte stage that marks the beginning of hemoglobinization is called:

A) Basophilic normoblast
B) Polychromatophilic normoblast
C) Orthochromic normoblast
D) Pronormoblast

Question 5

Reversible sickled cells are described as having a:

A) Crescent shape with one pointed projection
B) Crescent shape with two pointed projections
C) Half-moon shape with rounded ends
D) Half-moon shape with pointed projection

Question 6

Pappenheimer bodies are composed of:

A) Iron
B) Denatured hemoglobin
C) DNA
D) RNA

Question 7

The degree of effective erythropoietic activity in any hematological disorder is most readily assessed by a/an:

A) Red cell count
B) Reticulocyte count
C) M:E ratio
D) Hemoglobin determination

Question 8

The red cell protein that is responsible for deformability and flexibility of the red cell is:

A) Spectrin
B) Glycophorin
C) Glycine
D) EPO

Question 9

Describe the hemoglobin content of the cell at the end of the pointer.

A) Normochromic
B) Hypochromic
C) Polychromatophilic
D) Hyperchromic

Question 10

Polychromatophilic macrocytes in the peripheral smear are most likely:

A) Siderocytes
B) Reticulocytes
C) Spherocytes
D) Pappenheimer bodies

Question 11

Which of the following RBC pathways is responsible for providing 90% of the cellular ATP for red cell metabolism?

A) Embden-Meyerhof pathway
B) Methemoglobin reductase pathway
C) Rapoport-Luebering pathway
D) Hexose monophosphate shunt

Question 12

Red cell inclusions that are remnants of DNA are termed:

A) Cabot rings
B) Howell Jolly bodies
C) Heinz bodies
D) Pappenheimer bodies

Question 13

The red cell inclusion derived from denatured hemoglobin are:

A) Howell-Jolly bodies
B) Pappenheimer bodies
C) Heinz bodies
D) Siderotic granules

Question 14

Identify the cell at the end of the pointer.

A) Spherocyte
B) Schistocyte
C) Acanthocyte
D) Normocyte

Question 15

The hemoglobin molecule consists of:

A) One heme molecule, one globin chain
B) One heme molecule, four globin chains
C) Two heme molecules, two globin chains
D) Four heme molecules, four globin chains

Question 16

From each pronormoblast precursor cell, _mature red blood cells are produced.

A) 4
B) 8
C) 12
D) 16

Question 17

When hemolysis is produced by the intravascular fragmentation of red cells, which red cell morphology will be produced?

A) Spherocytes
B) Macrocytes
C) Acanthocytes
D) Schistocytes

Question 18

Asynchrony in the bone marrow is defined as the:

A) Presence of nucleoli throughout each maturation phase
B) Presence of extremely basophilic cytoplasm in all precursors
C) Lack of nuclear development in precursor cells
D) Nuclear development and hemoglobin development that is unbalanced

Question 19

The basic pathophysiology of the thalassemic conditions is a/an:

A) Decreased or absent globin chain synthesis
B) Absence of iron absorption
C) Failure to incorporate iron into the pronormoblast
D) Side effect of iron overload

Question 20

Increased plasma cholesterol may lead to the development of which of these abnormal red cell morphologies?

A) Spherocytes
B) Target cells
C) Microcytes
D) Helmet cells

Question 21

The anucleate mature red blood cell has no ability to produce protein.

Question 22

The term used to describe the inclusions seen in the cell at the end of the pointer is (Wright's stain):

A) Pappenheimer bodies
B) Basophilic stippling
C) Howell Jolly bodies
D) Siderotic granules

Question 23

Identify the cell at the end of the pointers.

A) Reticulocyte
B) Spherocyte
C) Sickle cell
D) Target cell

Question 24

The higher the N:C ratio, the more mature the cell.