Deck 9: Nonnarcotic Anti-Inflammatory Analgesics Nsaids

Question 1

Damage to the organ most sensitive to acetaminophen overdose is potentiated by concomitant use of:

A)aspirin.
B)NSAIDs.
C)morphine.
D)alcohol.

Answer 1

D

Question 2

Older NSAIDs (such as aspirin)affect:

A)COX-1.
B)COX-2.
C)both COX-1 and COX-2.
D)neither COX-1 nor COX-2.

Answer 2

C

Question 3

Ibuprofen is similar to:

A)aspirin in that it increases blood clotting.
B)acetaminophen in that it increases blood clotting.
C)aspirin in that it decreases blood clotting.
D)acetaminophen in that it decreases blood clotting.

Answer 3

C

Question 4

The prototypical COX-2 inhibitor is:

A)morphine.
B)acetaminophen.
C)Celebrex.
D)aspirin.

Question 5

One of the main differences between aspirin and acetaminophen relates to:

A)anti-inflammatory effects.
B)analgesic effects.
C)antipyretic effects.
D)All of the answers are correct.

Question 6

The incidence of the following side effect is halved by selective,versus nonselective,COX inhibitors:

A)blood thinning (anti-coagulation).
B)blood clotting.
C)gastric upset.
D)ringing in the ear.

Question 7

Prostaglandins affected by COX-2 are involved in:

A)mediation of immune responses.
B)mediation of inflammatory responses.
C)mediation of pain.
D)All of the answers are correct.

Question 8

Prostaglandins affected by COX-1 are involved in:

A)regulation of gastrointestinal cell function.
B)regulation of blood clotting.
C)mediation of inflammation and pain.
D)regulation of gastrointestinal cell function and blood clotting.

Question 9

Aspirin:

A)increases blood clotting.
B)decreases blood clotting.
C)increases risk of stroke.
D)increases blood clotting and the risk of stroke.

Question 10

The mechanism of action of the NSAIDs is:

A)inhibition of prostaglandins.
B)facilitation of prostaglandins.
C)inhibition of COX.
D)facilitation of COX.

Question 11

NSAIDs produce:

A)analgesia.
B)anti-inflammatory effects.
C)antipyretic effects.
D)All of the answers are correct.

Question 12

A major role of COX-l is to:

A)initiate blood clotting.
B)prevent coagulation.
C)decrease inflammation.
D)decrease pain.

Question 13

A main difference between aspirin and acetaminophen relates to:

A)analgesic effect.
B)platelet aggregation.
C)antipyretic effects.
D)All of the answers are correct.

Question 14

Toradol is unique in comparison to other nonnarcotic analgesics in that:

A)it is not an NSAID.
B)it does not inhibit COX.
C)it does not alter prostaglandins synthesis.
D)it is injectable.

Question 15

A major role of COX-2 is to:

A)mediate pain.
B)initiate blood clotting.
C)protect GI cells.
D)initiate blood clotting and protect GI cells.

Question 16

Aspirin affects:

A)COX-1.
B)COX-2.
C)both COX-1 and COX-2.
D)neither COX-1 nor COX-2.

Question 17

Overdose of aspirin may be recognized by the following symptom(s):

A)panting.
B)ringing in the ears.
C)panting and ringing in the ears.
D)neither panting nor ringing in the ears.

Question 18

The mechanism of action of cyclooxygenase is:

A)via mediation of the synthesis of prostaglandins.
B)via enzymatic breakdown of prostaglandins.
C)via increased synthesis of COX.
D)via decreased synthesis of COX.

Question 19

The prototypical nonselective NSAID is:

A)morphine.
B)acetaminophen.
C)Celebrex.
D)aspirin.

Question 20

Overdose of acetaminophen is most toxic to the following organ:

A)brain.
B)stomach.
C)kidneys.
D)liver.

Question 21

One of the main differences between acetaminophen and ibuprofen is the anti-inflammatory effect.

Question 22

A major side effect of COX-2 inhibitors would be gastrointestinal toxicity.

Question 23

Aspirin,ibuprofen,and acetaminophen all share antipyretic effects.

Question 24

Inhibition of COX-2 has all of the following actions,EXCEPT:

A)decreasing pain.
B)decreasing inflammation.
C)decreasing platelet aggregation.
D)decreasing the risk of cancer of the colon.

Question 25

A major side effect of COX-2 inhibitors would be decreased platelet aggregation.

Question 26

COX-2 inhibitors (e.g.,Bextra and Vioxx)are approved to treat:

A)arthritis.
B)pain.
C)menstrual cramps.
D)None of the answers is correct.

Question 27

Inhibition of COX-2 reduces:

A)pain.
B)inflammation.
C)pain and inflammation.
D)neither pain nor inflammation.

Question 28

Aspirin reduces blood clotting by affecting the COX-2 isoform of the COX enzyme.

Question 29

The COX-2 isoform of the COX enzyme is involved in inflammation.

Question 30

The main difference between aspirin and ibuprofen is the anti-inflammatory effect.

Question 31

COX-2-selective NSAIDs may be preferable to nonselective NSAIDs because:

A)COX-2 NSAIDs produce greater analgesia.
B)COX-2 NSAIDs produce greater anti-inflammatory effects.
C)COX-2 NSAIDs produce greater effects on platelet function.
D)COX-2 NSAIDs produce less gastric upset.

Question 32

The major side effect of aspirin is gastrointestinal toxicity.

Question 33

A major side effect of aspirin is decreased platelet aggregation.

Question 34

Celebrex:

A)selectively inhibits COX-1.
B)selectively inhibits COX-2.
C)nonselectively inhibits both COX-1 and COX-2.
D)is unique in not affecting either COX-1 or COX-2.

Question 35

Unlike acetaminophen,ibuprofen has analgesic,anti-inflammatory,and antipyretic effects.

Question 36

Unlike aspirin,ibuprofen has analgesic,anti-inflammatory,and antipyretic effects.

Question 37

Inhibition of COX-2 produces pain and inflammation.

Question 38

Aspirin's antipyretic effect occurs in the brain.

Question 39

When attached to aspirin,nitric oxide decreases the:

A)blood clotting effect of aspirin.
B)anti-pyretic effect of aspirin.
C)gastrointestinal injury associated with aspirin.
D)anti-inflammatory effect of aspirin.

Question 40

Inhibition of COX-1 reduces pain and inflammation.

Question 41

COX-2 inhibitors inhibit some cancers.

Question 42

Nitric oxide protects the gastrointestinal tract from aspirin-induced injury.

Question 43

Unlike aspirin,ibuprofen does not inhibit prostaglandins.

Question 44

Vioxx is approved for the treatment of osteoarthritis.